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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 37

Pael-R, GPR37, Parkin-associated endothelin receptor-like receptor
Top mentioned proteins: E3 ubiquitin ligase, Ubiquitin, endothelin-1, CAN, HRD1
Papers on Pael-R
CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.
New
Momoi et al., ƌtawara, Japan. In J Neurochem, Aug 2015
GPR37 is a receptor for survival factors.
Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
New
Ciruela et al., Barcelona, Spain. In Behav Brain Res, Aug 2015
GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease.
The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.
New
Ciruela et al., Coimbra, Portugal. In J Neurochem, Jul 2015
GPR37 is an orphan G protein-coupled receptor mostly enriched in brain areas such as the cerebellum, striatum, and hippocampus.
Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor.
New
Tocchini-Valentini et al., Roma, Italy. In Faseb J, May 2015
The mammalian G-protein-coupled receptor 37 (GPR37) is expressed in brain, in adult testis, and during the early phase of gonad differentiation.
Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1.
Review
Smith, Australia. In Front Pharmacol, 2014
Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR37 [ET(B)R-LP, Pael-R] and GPR37L1 [ET(B)R-LP-2].
A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival.
Zhang et al., Nantong, China. In Pathol Res Pract, 2014
GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR).
The protective role of prosaposin and its receptors in the nervous system.
Review
Hall et al., Atlanta, United States. In Brain Res, 2014
The ability of secreted prosaposin to promote protective effects in the nervous system is known to involve activation of G proteins, and the orphan G protein-coupled receptors GPR37 and GPR37L1 have recently been shown to mediate signaling induced by both prosaposin and a fragment of prosaposin known as prosaptide.
Vitamin D Metabolites Inhibit Hepatitis C Virus and Modulate Cellular Gene Expression.
Wyles et al., San Antonio, United States. In J Virol Antivir Res, 2014
Genes involved with classical effects of vitamin D metabolism and excretion were activated, along with genes linked to autophagy such as G-protein coupled receptor 37 (GPR37) and Hypoxia-inducible factor 1-alpha (HIF1a).
The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.
Dev et al., Dublin, Ireland. In J Neurochem, 2014
The parkin-associated endothelial-like receptor (PAELR, GPR37) is an orphan G protein-coupled receptor that interacts with and is degraded by parkin-mediated ubiquitination.
The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.
Hu et al., Changsha, China. In Neural Regen Res, 2014
An RNA interference vector targeting Parkin-associated endothelin receptor-like receptor (Pael-R) was transfected into the model cells.
Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle.
Morris et al., Galway, Ireland. In Bmc Genomics, 2013
Among these, GPR37 (G protein-coupled receptor 37), HEYL (hairy/enhancer-of-split related with YRPW motif-like), DNJA1, CD14 (Cluster of differentiation 14) and GNS (glucosamine (N-acetyl)-6-sulfatase) are known to be associated with hepatic metabolic disorders.
[Pharmacological studies on neurodegenerative diseases focusing on refolding and degradation of unfolded proteins in the endoplasmic reticulum].
Review
Nomura, Yokohama, Japan. In Yakugaku Zasshi, 2013
In addition, we identified the novel E3 ubiquitin ligase HRD1 and observed that HRD1 activates degradation of Parkin-associated endothelin receptor-like receptor (Pael-R).
G protein-linked signaling pathways in bipolar and major depressive disorders.
Vawter et al., Irvine, United States. In Front Genet, 2012
Two orphan GPCRs, GPRC5B and GPR37, showed significantly decreased expression levels in MDD, and significantly increased expression levels in BPD.
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease.
Review
Nomura et al., Kyoto, Japan. In Oxid Med Cell Longev, 2012
HRD1 promotes the ubiquitination and degradation of Parkin-associated endothelin receptor-like receptor (Pael-R), an ER stress inducer and causative factor of familial PD, thereby preventing Pael-R-induced neuronal cell death.
[Molecular pharmacological studies on the protection mechanism against endoplasmic reticulum stress-induced neurodegenerative disease].
Review
Kaneko, Chiba, Japan. In Yakugaku Zasshi, 2011
In familial Parkinson's disease, accumulation of Parkin-associated endothelin receptor-like receptor (Pael-R), a substrate of ubiquitin ligase Parkin involved in ERAD, leads to ER stress and apoptosis.
GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.
GeneRIF
Hall et al., Atlanta, United States. In Biochemistry, 2009
GPR37 surface trafficking in heterologous cells can be greatly enhanced by N-terminal truncation, coexpression with other receptors, and coexpression with syntenin-1.
Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration.
GeneRIF
Tocchini-Valentini et al., Roma, Italy. In Autophagy, 2009
Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration
Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor.
GeneRIF
Tocchini-Valentini et al., Roma, Italy. In Faseb J, 2009
Data show that GPR37 overexpression can induce cellular autophagy, which may prevent the selective degeneration of GPR37-expressing neurons, as reported for Parkinson's and related neurodegenerative diseases.
Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss.
GeneRIF
Takahashi et al., Kyoto, Japan. In J Neurochem, 2008
Parkin-ko/Pael-R-tg mice represents an AR-JP mouse model displaying chronic and selective loss of catecholaminergic neurons.
GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.
GeneRIF
Tocchini-Valentini et al., Roma, Italy. In Proc Natl Acad Sci U S A, 2007
GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.
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