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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein kinase, interferon-inducible double stranded RNA dependent activator

PACT, R X, RAX
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: PKR, CAN, NRC, Dicer, ACID
Papers using PACT antibodies
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells
Supplier
Bluestone Jeffrey A. et al., In The Journal of Experimental Medicine, 1994
... A mouse T cell lymphoma MATCHMAKER cDNA library in pACT (Clontech) was screened using the ...
Papers on PACT
Substituent effect and wavelength dependence of the photoinduced Ru-O homolysis in the [Ru(bpy)2(py-SO3)](+)-type complexes.
New
Wang et al., Beijing, China. In Dalton Trans, Feb 2016
Such complexes have dual activities of photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) under hypoxic conditions and are therefore promising as a new class of antitumor drugs.
DDX3 functions in antiviral innate immunity through translational control of PACT.
New
Tarn et al., Taiwan. In Febs J, Jan 2016
We found that the expression of the protein activator of the interferon-induced protein kinase (PACT) was regulated by DDX3 in human cells.
The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.
New
Sen et al., Cleveland, United States. In Febs J, Dec 2015
The murine double-stranded RNA-binding protein termed protein kinase R (PKR)-associated protein X (RAX) and the human homolog, protein activator of PKR (PACT), were originally characterized as activators of PKR.
Activation of Wnt/ß-catenin signaling in ESC promotes rostral forebrain differentiation in vitro.
New
Sasai et al., Kōbe, Japan. In In Vitro Cell Dev Biol Anim, Dec 2015
Here, using Rax, rostral forebrain marker, and Wnt/ß-catenin reporter lines, we report ratio of Rax(+) and Wnt responding tissue (Wnt(+)) patterns, which were affected by seeding number of ESC in three-dimensional culture system.
5,5'-Diamino-BIPHEP ligands bearing small selector units for non-covalent binding of chiral analytes in solution.
New
Trapp et al., Heidelberg, Germany. In Chem Commun (camb), Dec 2015
(Rax, S(Phe)) and (Sax, S(Phe)) adducts were observed as significantly separated species in NMR spectroscopy.
The WRKY Transcription Factor WRKY71/EXB1 Controls Shoot Branching by Transcriptionally Regulating RAX Genes in Arabidopsis.
New
Qin et al., Beijing, China. In Plant Cell, Nov 2015
Disruption of the RAX genes partially rescues the branching phenotype caused by EXB1 overexpression.
Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs.
Review
New
Plevin et al., York, United Kingdom. In Wiley Interdiscip Rev Rna, May 2015
HIV TAR RNA-binding protein (TRBP) and Protein Activator of PKR (PACT) are double-stranded (ds) RNA-binding proteins that participate in both small regulatory RNA biogenesis and the response to viral dsRNA.
PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine.
Kok et al., Hong Kong, Hong Kong. In J Virol, 2014
Its IFN-β-inducing activity was further enhanced when both cytoplasmic RNA sensor RIG-I and its partner, PACT, were overexpressed.
MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells.
Yokosuka et al., Chiba, Japan. In Plos One, 2014
Here, we showed that the transient inhibition of PKR-activating protein (PACT) expression, by miR-122 or siRNA targeting of PACT, suppressed the production of proinflammatory cytokines, such as interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1) and IL-1β, in human HSC LX-2.
Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration.
Xu et al., Shanghai, China. In Stem Cell Res Ther, 2014
To generate Rax::EGFP knock-in rESC lines, TALENs were engineered to facilitate homologous recombination in rESCs, which were cotransfected with the targeting vector and TALEN vectors.
Molecular cloning and expression analysis of five GhRAXs in upland cotton (Gossypium hirsutum L.).
Wang et al., Shanghai, China. In Genet Mol Res, 2014
Several transcription factor-encoding genes, including CUC3, RAX, LAS, LOF1, and ROX, have been cloned by screening for axillary meristem mutants in Arabidopsis thaliana.
HIV-1 translation and its regulation by cellular factors PKR and PACT.
Review
Gatignol et al., Montréal, Canada. In Virus Res, 2014
The cellular TAR RNA Binding Protein, TRBP, the Adenosine Deaminase acting on RNA, ADAR1, and the PKR Activator, PACT, play important roles.
Regulation of miRNA strand selection: follow the leader?
Review
Bushell et al., Leicester, United Kingdom. In Biochem Soc Trans, 2014
Several proteins are known to play a role in strand selection [Ago (Argonaute), DICER, TRBP (trans-activation response RNA-binding protein), PACT (protein activator of dsRNA-dependent protein kinase) and Xrn-1/2]; however, the mechanisms by which these proteins act are largely unknown.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
Review
FitzPatrick et al., Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.
'Black sheep' that don't leave the double-stranded RNA-binding domain fold.
Review
Maquat et al., Rochester, United States. In Trends Biochem Sci, 2014
We exemplify the growing importance of divergent dsRBDs in mRNA decay by discussing Dicer, Staufen (STAU)1 and 2, trans-activation responsive RNA-binding protein (TARBP)2, protein activator of protein kinase RNA-activated (PKR) (PACT), DiGeorge syndrome critical region (DGCR)8, DEAH box helicase proteins (DHX) 9 and 30, and dsRBD-like fold-containing proteins that have ribosome-related functions.
Increased interaction between PACT molecules in response to stress signals is required for PKR activation.
GeneRIF
Patel et al., Columbia, United States. In J Cell Biochem, 2012
Data demonstrate that PACT-PACT interaction is essential for efficient PKR activation.
Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD.
GeneRIF
Umezawa et al., Japan. In Plos One, 2011
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
RAX and anophthalmia in humans: evidence of brain anomalies.
GeneRIF
Schorderet et al., Lausanne, Switzerland. In Mol Vis, 2011
The three consanguineous Egyptian anophthalmia patients carry a novel homozygous c.543+3A>G mutation (IVS2+3A>G) in RAX.
The role of Dicer protein partners in the processing of microRNA precursors.
GeneRIF
Krzyzosiak et al., Poznań, Poland. In Plos One, 2010
AGO2, PACT and TRBP are required for the efficient functioning of Dicer in cells
Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.
GeneRIF
Hérault et al., Cleveland, United States. In Plos One, 2010
These observations identified a specific mutation that reduces steady-state levels of RAX protein and disrupts the dsRNA binding function of the protein, demonstrating the importance of the Prkra gene in various aspects of mouse development.
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