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Phosphofurin acidic cluster sorting protein 1

PACS-1, phosphofurin acidic cluster sorting protein 1
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PACS-1
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.
GeneRIF
Thomas et al., Portland, United States. In Mol Biol Cell, 2012
The sites on Nef and the PACS proteins required for their interaction, are identified.
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons.
GeneRIF
Martens et al., Ann Arbor, United States. In J Neurosci, 2009
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b in olfactory sensory neurons.
A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.
GeneRIF
Thomas et al., Portland, United States. In Embo J, 2006
CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported.
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.
GeneRIF
Benzing et al., Freiburg, Germany. In Embo J, 2006
casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.
GeneRIF
Walz et al., Freiburg, Germany. In Embo J, 2005
subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2
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