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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adenylate cyclase activating polypeptide 1 receptor 1a

PAC1 receptor
Top mentioned proteins: PACAP, Vasoactive Intestinal Peptide, VPAC2, VPAC1, V1a
Papers on PAC1 receptor
Pituitary adenylate cyclase-activating peptide (PACAP) and PAC1 receptor in the testis of cartilaginous fish Torpedo marmorata: A molecular and phylogenetic study.
Prisco et al., Napoli, Italy. In Comp Biochem Physiol B Biochem Mol Biol, Jan 2016
In this paper we investigated the sequence, expression and localization of PACAP and its PAC1 receptor in the testis of the benthic elasmobranch Torpedo marmorata, the marbled electric ray.
Altered Circadian Food Anticipatory Activity Rhythms in PACAP Receptor 1 (PAC1) Deficient Mice.
Fahrenkrug et al., Copenhagen, Denmark. In Plos One, Dec 2015
PAC1 receptor knock out (PAC1-/-) and wild type (PAC1+/+) mice placed in running wheels were examined in a full photoperiod (FPP) of 12:12 h light/dark (LD) and a skeleton photoperiod (SPP) 1:11:1:11 h L:DD:L:DD at 300 and 10 lux light intensity.
PACAP intraperitoneal treatment suppresses appetite and food intake via PAC1 receptor in mice by inhibiting ghrelin and increasing GLP-1 and leptin.
Germano et al., Los Angeles, United States. In Am J Physiol Gastrointest Liver Physiol, Dec 2015
Pituitary adenylate cyclase-activating peptide (PACAP) is expressed within the gastroenteric system, where it has profound physiological effects.
Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons.
Szőke et al., Pécs, Hungary. In Neuroscience, Dec 2015
Slowly increasing intracellular free calcium concentration [Ca(2+)]i was detected after PACAP1-38, PACAP1-27, vasoactive intestinal polypeptide (VIP) and the selective PAC1 receptor agonist maxadilan administration on TRG neurons, but interestingly, PACAP6-38, VIP6-28 and the PAC1 receptor antagonist M65 also caused similar activation.
Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine.
Goadsby et al., San Francisco, United States. In Sci Transl Med, Nov 2015
Only intravenous delivery of a PAC1 receptor antagonist inhibited the peripheral meningeal vasodilatory effects of dural trigeminovascular nociception, whereas only central (intracerebroventricular) administration of the PAC1 receptor antagonist inhibited dural nociceptive-evoked action potentials in central trigeminovascular neurons.
Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability.
Parsons et al., Burlington, United States. In Am J Physiol Cell Physiol, Jul 2015
PACAP/PAC1 receptor signaling increases excitability of neurons within the guinea pig cardiac ganglia, making them a unique system to establish mechanisms underlying PACAP modulation of neuronal function.
Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Huganir et al., Baltimore, United States. In Proc Natl Acad Sci U S A, Jun 2015
Increases in GluA1 S845 phosphorylation primarily occurred via PAC1 and VPAC2 receptor activation, whereas a reduction in GluA1 T840 phosphorylation was largely driven by PAC1 receptor activation and to a lesser extent by VPAC1 and VPAC2 receptor activation.
Impact of PACAP and PAC1 receptor deficiency on the neurochemical and behavioral effects of acute and chronic restraint stress in male C57BL/6 mice.
Eiden et al., Bethesda, United States. In Stress, 2014
We conclude that while a PACAP receptor in addition to PAC1 may mediate some of the PACAP-dependent central effects of ARS and short-term (<7 days) CRS on the hypothalamo-pituitary-adrenal (HPA) axis, the PAC1 receptor plays a prominent role in mediating PACAP-dependent HPA axis activation, and hypophagia, during long-term (>7 days) CRS.
PACAP and PAC1 receptor in brain development and behavior.
Collier et al., Galway, Ireland. In Neuropeptides, 2013
This review focuses on role of PACAP and PAC1 receptor in brain development, behavior of animals and potential implication in human neurodevelopmental disorders.
Possible role of PACAP and its PAC1 receptor in the differential regulation of pituitary LHbeta- and FSHbeta-subunit gene expression by pulsatile GnRH stimulation.
Miyazaki et al., Izumo, Japan. In Biol Reprod, 2013
The pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are mainly under the control of hypothalamic gonadotropin-releasing hormone (GnRH), which regulates male and female gonadal function.
Fear extinction and BDNF: translating animal models of PTSD to the clinic.
Ressler et al., Atlanta, United States. In Genes Brain Behav, 2012
Recent work also finds that the pituitary adenylate cyclase-activating polypeptide and PAC1 receptor, which are upstream of BDNF activation, may be implicated in PTSD.
Effect of PACAP in central and peripheral nerve injuries.
Bukovics et al., Pécs, Hungary. In Int J Mol Sci, 2011
Expression of endogenous PACAP and its specific PAC1 receptor is elevated in different parts of the central and peripheral nervous system after traumatic injuries.
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.
May et al., United States. In Nature, 2011
In contrast, it is unclear if the PACAP-PAC1 receptor pathway has a role in human psychological stress responses, such as post-traumatic stress disorder (PTSD).
Expression analysis of PAC1-R and PACAP genes in zebrafish embryos.
Waschek et al., Mont-Saint-Aignan, France. In J Mol Neurosci, 2011
These results suggest that, in fish, PACAP and PAC1-R may play a role in brain development.
Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish.
Sherwood et al., Victoria, Canada. In Mol Cell Endocrinol, 2005
signal pathways, transcript distribution, and splice variants are investigated
Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.
Vaudry et al., Mont-Saint-Aignan, France. In Pharmacol Rev, 2000
Molecular cloning of PACAP receptors has shown the existence of three distinct receptor subtypes, the PACAP-specific PAC1 receptor, which is coupled to several transduction systems, and the two PACAP/VIP-indifferent VPAC1 and VPAC2 receptors, which are primarily coupled to adenylyl cyclase.
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