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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Sestrin 1

PA26, SESN1
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Papers on PA26
Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling.
GeneRIF
Devriendt et al., Leuven, Belgium. In Hum Mol Genet, 2006
identify SESN1 as an indispensable gene for vertebrate left-right asymmetry and a new player in mediating Nodal signaling
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.
Impact
GeneRIF
Chumakov et al., Cleveland, United States. In Science, 2004
results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H
PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.
GeneRIF
Devriendt et al., Leuven, Belgium. In Hum Genet, 2003
PA26 mutations are an infrequent cause of heterotaxia (situs inversus) in humans.
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