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Protein phosphatase 1, regulatory subunit 10

P99, PNUTS, FB19
This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis. This gene lies within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PP1, CAN, V1a, PCNA, miR
Papers on P99
Protein phosphatase 1 is a key player in nuclear events.
Review
New
da Cruz E Silva et al., Aveiro, Portugal. In Cell Signal, Dec 2015
Among them are PNUTS (phosphatase 1 nuclear targeting subunit), NIPP1 (nuclear inhibitor of PP1) and CREB (cAMP-responsive element-binding protein), which have all been associated with transcription.
The miRNA miR-34a enhances HIV-1 replication by targeting PNUTS/PPP1R10, which negatively regulates HIV-1 transcriptional complex formation.
New
Banerjea et al., New Delhi, India. In Biochem J, Oct 2015
We show that the mechanism of action of miR-34a in HIV-1 replication involves a cellular protein, the phosphatase 1 nuclear-targeting subunit (PNUTS).
Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.
New
Bollen et al., Leuven, Belgium. In Nucleic Acids Res, Aug 2015
RepoMan, NIPP1 and PNUTS.
Endocytosis of GABA(C) receptors depends on subunit composition and is regulated by protein kinase C-ζ and protein phosphatase 1.
New
Enz et al., Erlangen, Germany. In J Neurochem, Jul 2015
Previously, we reported physical interactions of GABA(C)R ρ subunits with protein kinase C-ζ (PKCζ) via adapter proteins of the ZIP protein family, as well as of protein phosphatase 1 (PP1) via PNUTS.
[Prenatal screening for anueploidies in the first trimester: Audit to a Fetal Medicine Centre with specialized Laboratory in Mexico].
New
Ruíz-Ramírez et al., In Ginecol Obstet Mex, May 2015
1080 foetuses with 1009 valid measurements of nuchal translucency (29.8% at external cabinets), 54% >p50; 7.3% >p95, and 1.6% > p99.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
Impact
Yang et al., Houston, United States. In Cell, 2014
BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase.
CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.
Bernard et al., Lyon, France. In Plos Genet, 2014
However, CPF-associated Swd2.2 is required for the association of Protein Phosphatase 1 PP1(Dis2) with chromatin, through an interaction with Ppn1, a protein that we identify as the fission yeast homologue of vertebrate PNUTS.
microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells.
Sun et al., Hefei, China. In Cell Signal, 2014
In addition, NT-2 cells were remarkably sensitized to DNA damage reagent (cisplatin) by forcing expression of miR-383 and silencing expression of protein phosphatase 1, regulatory subunit 10 (PNUTS).
Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Page et al., Providence, United States. In Proc Natl Acad Sci U S A, 2014
PP1 nuclear targeting subunit (PNUTS) is a PP1 targeting protein that, with PP1, plays a central role in the nucleus, where it regulates chromatin decondensation, RNA processing, and the phosphorylation state of fundamental cell cycle proteins, including the retinoblastoma protein (Rb), p53, and MDM2.
miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells.
Zhao et al., In Tumour Biol, 2014
Injection of Ad-miR-34a downregulated PNUTS expression and reduced telomere length in xenograft GBC tumor cells.
Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax.
Krucher et al., United States. In Cell Cycle, 2013
Mutant Rb proteins expressed in Rb-null C33A cells showed that phosphorylation of S807 of Rb promotes association with Bax and that mimicking phosphorylation at S807 of Rb can block the induction of apoptosis due to PNUTS downregulation.
PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.
Bennett et al., Liverpool, United Kingdom. In Plos Genet, 2013
Together, these findings shed light on the in vivo role of the PNUTS-PP1 holoenzyme and its contribution to the control of gene expression during early Drosophila development.
Keep PNUTS in your heart.
Lee et al., Boston, United States. In Circ Res, 2013
Aging is a major factor in many cardiovascular diseases.
miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!
Impact
Dorn, Saint Louis, United States. In Cell Metab, 2013
(2013) describe DNA damage mechanisms and cardiac senescence provoked by miR-34a and its target, PNUTS.
MicroRNA-34a regulates cardiac ageing and function.
Impact
Dimmeler et al., Frankfurt am Main, Germany. In Nature, 2013
Mechanistically, we identified PNUTS (also known as PPP1R10) as a novel direct miR-34a target, which reduces telomere shortening, DNA damage responses and cardiomyocyte apoptosis, and improves functional recovery after acute myocardial infarction.
The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.
GeneRIF
Küntziger et al., Oslo, Norway. In Embo Rep, 2010
PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair.
Identification and characterization of a novel human PP1 phosphatase complex.
GeneRIF
Skalnik et al., Indianapolis, United States. In J Biol Chem, 2010
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.
GeneRIF
Krucher et al., United States. In Int J Oncol, 2010
stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation.
GeneRIF
Porto et al., Porto, Portugal. In Neurosci Lett, 2009
no evidence found of association between a CAT53 polymorphism and Alzheimer's Disease (AD), but found a significant negative association of the C282Y HFE mutation with AD
Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation.
GeneRIF
Kwon et al., Seoul, South Korea. In Exp Mol Med, 2009
the coordinated spatial and temporal regulation of LCP1 and PNUTS may be a novel mechanism to control the expression of genes that are critical for certain physiological and pathological processes.
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