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Phosphoinositide-3-kinase, regulatory subunit 1

p85, p85alpha
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: PI3K, Akt, Insulin, V1a, CAN
Papers using p85 antibodies
Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells
Supplier
Ahmad Aamir, In PLoS ONE, 2010
... Antibody against PI3K p85 (rabbit polyclonal) was from Abcam (Cambridge, MA, USA) ...
Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients.
Supplier
Kango-Singh Madhuri, In PLoS ONE, 2008
... Mouse monoclonal antibody against Bax (sc-7480); rabbit polyclonal antibody against 14-3-3ζ (sc-1019), pPI3K p85 antibody (Tyr-508, sc-12929R) were purchased from Santa Cruz Biotechnology, Santa Cruz, CA ...
Helical Packing Patterns in Membrane and Soluble Proteins
Supplier
Askari Amir et al., In Biochemistry, 2003
... (α6F) from Developmental Studies Hybridoma Bank, University of Iowa (Iowa City, IA); Akt and PI3K p85 from Cell Signaling Technology (Danvers, MA); and ...
Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis
Supplier
Lowe Martin et al., In The Journal of Cell Biology, 1997
... polyclonal anti-GM130, 4H1 monoclonal anti-p115, 3E1 monoclonal anti-GFP, monoclonal anti-GM130 from Transduction Labs, polyclonal anti-PARP p85 fragment from Promega (human specific) and Cell Signaling (rat specific), monoclonal anti-Fas ...
Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase
Supplier
Kubota Toshiaki et al., In Graefe's Archive for Clinical and Experimental Ophthalmology, 1995
... Antibodies were purchased from various vendors: anti-PI3K p85 and anti-phospho-PI3K p85 were from Cell Signaling Technology (Beverly, MA, USA) ...
more suppliers
Papers on p85
Calycosin‑7‑O‑β‑D‑glucoside attenuates ischemia‑reperfusion injury in vivo via activation of the PI3K/Akt pathway.
New
Liu et al., Harbin, China. In Mol Med Report, Jan 2016
The protein expression levels of cleaved‑caspase‑3, cleaved‑caspase‑9, phosphorylated (p)‑phosphatidylinositol 3‑kinase (PI3K) p85, PI3K p85, p‑Akt and Akt were determined using western blotting.
Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma.
New
Li et al., Guangzhou, China. In Oncotarget, Jan 2016
PKD2 bound directly to the p110α and p85 subunits of PI3K and promoted the PI3K/Akt/GSK-3β signaling cascade to stimulate EMT.
The effect of maternal and post-weaning low and high glycaemic index diets on glucose tolerance, fat deposition and hepatic function in rat offspring.
New
Muhlhausler et al., Adelaide, Australia. In J Dev Orig Health Dis, Jan 2016
body weight, P<0.05) and higher glucose tolerance (AUC[glucose], 1243±29 v. 1351±39 mmol min/l, P<0.05) at weaning, as well as lower hepatic PI3K-p85 mRNA at 12 weeks of age.
Antitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinoma.
New
Li et al., Weifang, China. In Oncol Lett, Oct 2015
The mechanism of RGZ-induced apoptosis involves an increase in the level of activated PPAR-γ (p-PPAR-γ) and a decrease in p85 and Akt expression.
Structure and function of Gab2 and its role in cancer (Review).
Review
New
Luo et al., Zunyi, China. In Mol Med Report, Sep 2015
Gab2 protein lacks intrinsic catalytic activity; however, when phosphorylated by protein‑tyrosine kinases (PTKs), Gab2 recruits several Src homology‑2 (SH2) domain‑containing proteins, including the SH2‑containing protein tyrosine phosphatase 2 (SHP2), the p85 subunit of phosphoinositide‑3 kinase (PI3K), phospholipase C‑γ (PLCγ)1, Crk, and GC‑GAP.
The S6K protein family in health and disease.
Review
New
Simabuco et al., Limeira, Brazil. In Life Sci, Jul 2015
S6K1 has two well-known isoforms, p70-S6K1 and p85-S6K1, generated by alternative translation initiation sites.
Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis.
Review
New
Jin et al., Rochester, United States. In Int J Cardiol, Mar 2015
Recent studies have revealed that Grb2-associated-binders (Gab) family members (including Gab1, Gab2, and Gab3), when phosphorylated on tyrosine residues, provide binding sites for multiple effector proteins, such as Src homology-2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) and phosphatidylinositol 3-kinase (PI3K) regulatory subunit p85, thereby playing important roles in transducing RTKs-mediated signals into pathways with diversified biological functions.
1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice.
Peng et al., Nanjing, China. In Molecules, 2014
Moreover, although expressions of total protein kinase B (AKT), phosphatidylinositol 3 kinase (PI3K), insulin receptor beta (IR-β), insulin receptor substrate-1 (IRS1) and glucose transporter 4 (GLUT4) in skeletal muscle were not affected, GLUT4 translocation and phosphorylation of Ser473-AKT, p85-PI3K, Tyr1361-IR-β and Tyr612-IRS1 were significantly increased by DNJ treatment.
The double life of p85.
Impact
Engelman et al., United States. In Cancer Cell, 2014
A growing number of mutations in PIK3R1, the gene that encodes for the p85α regulatory subunit of PI3K, have been recently identified.
The structural basis for cancer treatment decisions.
Review
Tsai et al., Tel Aviv-Yafo, Israel. In Oncotarget, 2014
Examples include redundant pathways taking over after inhibition of EGFR constitutive activation, mutations in PIK3CA p110α and p85, and the non-hotspot AKT1 mutants conferring constitutive membrane localization.
XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis.
Review
Liu et al., Toronto, Canada. In Scientifica (cairo), 2013
As a tyrosine kinase substrate, tyrosine phosphorylated XB130 associates with the p85 α regulatory subunit of phosphoinositol-3-kinase (PI3K) and subsequently affects Akt activity and its downstream signalling.
Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.
Impact
Wang et al., Cleveland, United States. In Cancer Cell, 2013
Here, we report that p110α E545K, but not p110α H1047R, gains the ability to associate with IRS1 independent of the p85 regulatory subunit, thereby rewiring this oncogenic signaling pathway.
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.
Impact
Pagano et al., New York City, United States. In Nat Cell Biol, 2013
We propose that FBXL2 and PTPL1 suppress p85β levels, preventing the inhibition of PI(3)K by an excess of free p85 that could compete with p85-p110 heterodimers for IRS1.
The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.
GeneRIF
Primo et al., Italy. In Biochim Biophys Acta, 2012
miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation.
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
Impact
GeneRIF
Dobyns et al., Seattle, United States. In Nat Genet, 2012
identified mutations in AKT3, PIK3R2 and PIK3CA in 11 unrelated families with megalencephaly-capillary malformation and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromes
miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma.
GeneRIF
Jiao et al., Shanghai, China. In Febs Lett, 2012
miR-376a may contribute to the development of hepatocellular carcinoma by targeting p85alpha
p85β phosphoinositide 3-kinase subunit regulates tumor progression.
GeneRIF
Carrera et al., Madrid, Spain. In Proc Natl Acad Sci U S A, 2012
p85beta phosphoinositide 3-kinase subunit regulates tumor progression
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
GeneRIF
Wang et al., Dalian, China. In Oncol Rep, 2012
the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Impact
Zhang et al., Xiamen, China. In Cancer Cell, 2010
We identified an N-terminally truncated RXRalpha (tRXRalpha) in several cancer cell lines and primary tumors, which interacted with the p85alpha subunit of phosphatidylinositol-3-OH kinase (PI3K).
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.
Impact
GeneRIF
Ozcan et al., Boston, United States. In Nat Med, 2010
heterodimerization disrupted by insulin, increasing nuclear translocation of XBP-1
More papers using p85 antibodies
Inhibitory effects of caffeine on contractions and calcium movement in vascular and intestinal smooth muscle
Supplier
Shin Heung Mook et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1987
... PI3K/p85 antibody was purchased from Cell Signaling Technology (Beverly, Mass, USA) ...
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by β1 integrins
Supplier
Zetter Bruce R. et al., In The Journal of Cell Biology, 1979
... The anti-p85 mAb was from BD Biosciences.
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