Neurotrophins and B-cell malignancies.
Galway, Ireland. In Cell Mol Life Sci, Jan 2016
The p75(NTR) and Trk receptors can elicit signalling in response to the presence or absence of their corresponding neurotrophin ligands.
Update on the role of p75NTR in neurological disorders: A novel therapeutic target.
Chongqing, China. In Biomed Pharmacother, Dec 2015
As a low-affinity neurotrophins receptor, p75 neurotrophin receptor (p75NTR) is a transmembrane receptor involved in a diverse array of cellular responses, including apoptosis, survival, neurite outgrowth, migration, and cell cycle arrest, which may be related to some neurological disorders, such as Alzheimer's disease (AD), schizophrenia, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD).
The p75 neurotrophin receptor: at the crossroad of neural repair and death.
Chapel Hill, United States. In Neural Regen Res, May 2015
Recently, the p75 neurotrophin receptor (p75(NTR)) has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system, 2) promotion of adult neurogenesis and 3) increased expression in neurons, macrophages, microglia, astrocytes and/or Schwann cells in response to injury and neurodegenerative diseases.
Cardiovascular actions of neurotrophins.
Bristol, United Kingdom. In Physiol Rev, 2009
Conversely, the neurotrophin low-affinity p75(NTR) receptor induces apoptosis of endothelial cells and vascular smooth muscle cells and impairs angiogenesis.