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Ribosomal protein S6 kinase, 70kDa, polypeptide 1

p70S6K, S6K, S6K1
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: mTOR, Akt, V1a, mTORC1, PI3K
Papers using p70S6K antibodies
Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.
Harrison Jeffrey K., In PLoS ONE, 2009
... as phospho-Akt S473, phospho-MAPK, total MAPK, phospho-4EBP1, phospho-S636/639, phospho-S1101 and phospho-S307 of IRS-1, S6K and phospho-S6K were obtained from Cell Signaling Technology (Beverly, MA) ...
Autophagy fights disease through cellular self-digestion
Wang Fen et al., In International Journal of Biological Sciences, 2007
... Tyr196 (1:1000), phosphorylated ERK1/2 (1:1000), phosphorylated Akt Thr308 (1:1000), phosphorylated Akt Ser473 (1:1000), and phosphorylated S6K1 Thr389 (1:1000) from Cell Signaling Technology Inc ...
Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms
Kundu Gopal C et al., In Molecular Cancer, 2007
... Rabbit anti-mTOR, anti-p-p70S6K antibodies and rapamycin were purchased from Cell Signaling Technology ...
Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1
Huang Shile et al., In Laboratory investigation; a journal of technical methods and pathology, 2007
... AMPKα, phospho-S6K1 (Thr389), S6K1 (all from Santa Cruz Biotechnology, Santa Cruz, CA); 4E-BP1 ...
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Chen Jie et al., In The Journal of Cell Biology, 2006
... anti-tubulin was obtained from Abcam, anti-MyoD (5.8A) was obtained from Imgenex, antibodies against HDAC4, mTOR, phospho–T389-S6K1, MEF2A, and MEF2C were obtained from Cell Signaling Technology, and all secondary ...
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Papers on p70S6K
Tissue-specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans.
Das et al., Winston-Salem, United States. In J Clin Endocrinol Metab, Feb 2016
Genes involved in eIF2, eIF4-p70S6K, and mTOR signaling were modulated with SI in both tissues.
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
Gomez-Cambronero et al., Boston, United States. In Mol Cell Biol, Feb 2016
The mechanism for this is, first, during initial starvation, an elevated PA (the product of PLD enzymatic activity) activates mTOR and S6K, known to inhibit apoptosis and enhances cell migration especially in post-EMT cancer cells.
Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice.
Chen et al., In Neoplasma, Feb 2016
Chidamide alone or in combination with 5-Fu down regulated the expressions of p-AKT, p-mammalian target of rapamycin (mTOR), p-p70S6K, p-Raf, and p44/42 mitogen activated protein kinase (Erk1/2), indicating the blockage of these signaling pathways.
Versatile antitumor potential of isoxanthohumol: enhancement of paclitaxel activity in vivo.
Maksimović-Ivanić et al., Belgrade, Serbia. In Pharmacol Res, Feb 2016
Despite the differences in which IXN promoted modifications in the upper part of the PI3K/Akt and MEK-ERK signaling pathways between B16 and A375 cells, p70S6K and its target S6 protein in both types of melanoma cells, after transient activation, became inhibited.
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism.
Rasmussen et al., Galveston, United States. In J Nutr, Feb 2016
Supplementation of protein/AAs with RE exhibited clear protein dose-dependent effects on translational regulation (protein synthesis) through mammalian target of rapamycin complex 1 (mTORC1) signaling, which was most apparent through increases in p70 ribosomal protein S6 kinase 1 (S6K1) phosphorylation, compared with postexercise recovery in the fasted or carbohydrate-fed state.
Antidepressant drug action--From rapid changes on network function to network rewiring.
Yalcin et al., Helsinki, Finland. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
Therapeutic effects of rapid-acting antidepressants have been linked with their ability to rapidly regulate neuronal excitability and thereby increase synaptic translation and release of BDNF, activation of the TrkB-mTOR-p70S6k signaling pathway and increased synaptogenesis within the prefrontal cortex.
Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity.
Deldicque et al., Louvain-la-Neuve, Belgium. In Nutrients, Dec 2015
While no difference was observed in the fasted state, in response to exercise and protein ingestion, the phosphorylation state of PKB (p < 0.05 in Pro and Pro+ex) and S6K1 (p = 0.059 in Pro; p = 0.066 in Pro+ex) was lower in the older subjects compared with the young subjects.
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
Erez et al., Israel. In Nature, Dec 2015
Building on these results, we demonstrate that ASS1 deficiency in cancer increases cytosolic aspartate levels, which increases CAD activation by upregulating its substrate availability and by increasing its phosphorylation by S6K1 through the mammalian target of rapamycin (mTOR) pathway.
mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets.
Yin et al., Changsha, China. In Eur J Immunol, Dec 2015
mTORC1 positively modulates IL-17 expression through several pathways, i.e STAT3, -HIF1α, -S6K1, and -S6K2.
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation.
Sahin et al., Boston, United States. In Cell, Jun 2015
The mTOR-effector kinase, ribosomal S6 protein kinase 1 (S6K1), an important regulator of translation, rhythmically phosphorylates BMAL1 at an evolutionarily conserved site.
[Research progress of p70 ribosomal protein S6 kinase inhibitors].
Li et al., In Yao Xue Xue Bao, Mar 2015
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade.
Reduced expression of MYC increases longevity and enhances healthspan.
Sedivy et al., Providence, United States. In Cell, Mar 2015
We also observe changes in nutrient and energy sensing pathways, including reduced serum IGF-1, increased AMPK activity, and decreased AKT, TOR, and S6K activities.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
Sansom et al., Paris, France. In Nature, Feb 2015
Importantly, treatment of established APC-deficient adenomas with rapamycin (which can target eEF2 through the mTORC1-S6K-eEF2K axis) causes tumour cells to undergo growth arrest and differentiation.
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Wei et al., Boston, United States. In Nat Cell Biol, 2013
Importantly, Sin1 phosphorylation, triggered by S6K or Akt, in a cellular context-dependent manner, inhibits not only insulin- or IGF-1-mediated, but also PDGF- or EGF-induced Akt phosphorylation by mTORC2, demonstrating a negative regulation of mTORC2 independent of IRS-1 and Grb10.
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
Kahn et al., Boston, United States. In Cell Metab, 2012
p70S6 kinase forms a complex with alpha2AMPK, resulting in phosphorylation on serine(491).
Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance.
Ray et al., Saint Louis, United States. In J Virol, 2012
Together, these observations suggested that hepatitis C virus infection activates the mTOR/S6K1 pathway in inhibiting IRS-1 function and perturbs glucose metabolism via downregulation of GLUT4 and upregulation of PCK2 for insulin resistance.
The crosstalk of mTOR/S6K1 and Hedgehog pathways.
Hung et al., Houston, United States. In Cancer Cell, 2012
An activated mTOR/S6K1 pathway promotes Gli1 transcriptional activity and oncogenic function through S6K1-mediated Gli1 phosphorylation at Ser84, which releases Gli1 from its endogenous inhibitor, SuFu.
Metabolic control by S6 kinases depends on dietary lipids.
Tschöp et al., Düsseldorf, Germany. In Plos One, 2011
metabolic functions of S6K in vivo play a key role as a molecular interface connecting dietary lipids to the endogenous control of energy metabolism.
MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1.
Jiang et al., Nanjing, China. In Plos One, 2011
the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis
More papers using p70S6K antibodies
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets*
Hers Ingeborg et al., In The Journal of Biological Chemistry, 2006
... Akt1(B-1) and p70S6K (H-9) antibodies were from Santa Cruz (Insight Biotechnology, Wembley, UK) ...
Cellular targets of gefitinib.
Zhang Lin, In PLoS ONE, 2004
... Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR (Cell Signaling Technology, #2983), phospho-P70S6K (T389) (Cell Signaling Technology, #9234), phospho-AKT (S473) ...
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
Luo Zhijun et al., In Oncogene, 2003
... Antibodies for total and phospho-T172 of AMPK, S6K1 and phospho-S389 S6K1, and clyclin D1 were from Cell Signaling Technology, Inc ...
Upstream and downstream of mTOR
Yang Zhihong et al., In BMC Cardiovascular Disorders, 2003
... anti-tubulin and all the other chemicals for immunoblotting were purchased from Sigma (Buchs, Switzerland); anti-phospho p70s6k (T389) was from Cell Signaling Technology ...
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
Lamb Richard F. et al., In The Journal of Cell Biology, 2002
... Antibodies to ERK1/2 and S6K1 were from Santa Cruz Biotechnology, Inc., and Transduction Laboratories, ...
Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth.
Parise Gianni, In PLoS ONE, 2001
... Rabbit anti-S6K1 was obtained from Santa Cruz Biotechnology (California, USA), rabbit-anti: p-S6K1 ...
Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control
Guan Jun-Lin et al., In The Journal of Cell Biology, 1997
... α-c-Myc-tag (9E10) antibody, rabbit polyclonal TSC2 antibody, rabbit polyclonal α-FAK (C20) antibody, and rabbit polyclonal S6K antibody were obtained from Santa Cruz Biotechnology, Inc ...
In vivo skin penetration studies of camomile flavones
Koul Hari, In PLoS ONE, 1993
... against the cleaved form of caspase 3, against phospho-AKT (Ser473), AKT, phospho-mTOR (Ser2448), phospho-p70S6K (Thr389), p70S6K and the secondary HRP-labeled goat-anti-mouse and goat-anti-rabbit antibodies, were obtained from Cell Signaling Technology (Beverly, MA) ...
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