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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Interleukin 2 receptor, beta chain

p70, Ephrin-A2, IL-2R beta
The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p70S6K, mTOR, Akt, IL-12, V1a
Papers using p70 antibodies
A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes*
Supplier
Czech Michael P. et al., In The Journal of Biological Chemistry, 2006
... Rabbit polyclonal antibodies against phospho-Akt/PKB Thr-308, phospho-Akt/PKB Ser-473, total Akt, phospho-p70 S6 kinase (Thr-389), and p70 S6 kinase were from Cell Signaling Technology (Beverly, MA) ...
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Supplier
Vellenga Edo et al., In Annals of Hematology, 2006
... Phospho-SRC family (Tyr416) antibody, phospho-ERK1/2 (Thr202/Tyr204) antibody, and phospho-p70 S6 kinase (Thr389) antibody were purchased from Cell Signaling (Leiden, the Netherlands) ...
Green tea epigallocatechin-3-gallate mediates T cellular NF-κB inhibition and exerts neuroprotection in autoimmune encephalomyelitis
Supplier
Kozawa Osamu et al., In Mediators of Inflammation, 2003
... phospho-specific SAPK/JNK kinase antibodies, SAPK/JNK antibodies, phospho-specific Akt antibodies, Akt antibodies, phospho-specific p70 S6 kinase antibodies, and p70 S6 kinase antibodies were purchased from Cell Signaling Technology (Beverly, Mass, USA) ...
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
Supplier
Bissell Mina J. et al., In The Journal of Cell Biology, 2002
... (12CA5; Roche), Phospho-Akt (serine 473 or threonine 308), total and phospho-GSK-3β (serine 9), total and phospho-p70 S6 kinase (threonine 389; Cell Signaling Technology), PIP3 monoclonal antibody ...
SOCS proteins: negative regulators of cytokine signaling.
Supplier
Hartl Dominik, In PLoS ONE, 2000
... 9106), phospho-p70 S6 Kinase (Thr389) antibody (Cell Signaling, Cat ...
Papers on p70
p-Cresyl sulfate suppresses lipopolysaccharide-induced anti-bacterial immune responses in murine macrophages in vitro.
New
Kaneko et al., Kunitachi, Japan. In Toxicol Lett, Feb 2016
Similar to RAW264.7 cells, pCS decreased IL-12 p40 and p70 production and increased IL-10 production in primary peritoneal macrophages.
Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression.
New
Sobue et al., Japan. In J Biol Chem, Feb 2016
DHA-mediated axon outgrowth was accompanied by the translational upregulation of Tau and collapsin response mediator protein 2 (CRMP2), two important axon-related proteins, and the activation of Akt and p70 S6 kinase (S6K).
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism.
Review
New
Rasmussen et al., Galveston, United States. In J Nutr, Feb 2016
Supplementation of protein/AAs with RE exhibited clear protein dose-dependent effects on translational regulation (protein synthesis) through mammalian target of rapamycin complex 1 (mTORC1) signaling, which was most apparent through increases in p70 ribosomal protein S6 kinase 1 (S6K1) phosphorylation, compared with postexercise recovery in the fasted or carbohydrate-fed state.
Global profiling of the signaling network of papillary thyroid carcinoma.
New
Zhang et al., New York City, United States. In Life Sci, Feb 2016
KEY FINDINGS: 11 were differentially expressed between tumors and surrounding tissues, 8 of which were up-regulated (cytokeratin 18, Stat 1, HMG-1, p-p70 S6 kinase, Raf-B, glutamine synthetase, p-PKC δ, and HDAC1), while 3 of which were down-regulated (cytokeratin 5, BECN1, and p-ERK).
Functional Regulation of PI3K-Associated Signaling in the Accumbens by Binge Alcohol Drinking in Male but not Female Mice.
New
Finn et al., Portland, United States. In Neuropharmacology, Feb 2016
Binge alcohol intake decreased mGlu5 levels in females, whereas it decreased indices of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), 4E-binding protein 1, and p70 ribosomal protein S6 kinase in males.
Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
New
Hedstrom et al., United States. In J Biol Chem, Feb 2016
In contrast, rapamycin preferentially inhibits the phosphorylation of p70(s6k) and blocks 35% of translation.
The S6K protein family in health and disease.
Review
New
Simabuco et al., Limeira, Brazil. In Life Sci, Jul 2015
S6K1 has two well-known isoforms, p70-S6K1 and p85-S6K1, generated by alternative translation initiation sites.
[Research progress of p70 ribosomal protein S6 kinase inhibitors].
Review
New
Li et al., In Yao Xue Xue Bao, Mar 2015
p70 ribosomal protein S6 kinase (p70S6K), an important member of AGC family, is a kind of multifunctional Ser/Thr kinases, which plays an important role in mTOR signaling cascade.
Taking aim at Alzheimer's disease through the mammalian target of rapamycin.
Review
Maiese, Newark, United States. In Ann Med, 2014
mTOR modulates multi-faceted signal transduction pathways that involve phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), hamartin (tuberous sclerosis 1)/ tuberin (tuberous sclerosis 2) (TSC1/TSC2) complex, proline-rich Akt substrate 40 kDa (PRAS40), and p70 ribosomal S6 kinase (p70S6K) and can interface with the neuroprotective pathways of growth factors, sirtuins, wingless, forkhead transcription factors, and glycogen synthase kinase-3β.
Driving neural regeneration through the mammalian target of rapamycin.
Review
Maiese, Newark, United States. In Neural Regen Res, 2014
mTOR through its relationship with phosphoinositide 3-kinase (PI 3-K) and protein kinase B (Akt) and multiple downstream signaling pathways such as p70 ribosomal S6 kinase (p70S6K) and proline rich Akt substrate 40 kDa (PRAS40) promotes neuronal cell regeneration through stem cell renewal and oversees critical pathways such as apoptosis, autophagy, and necroptosis to foster protection against neurodegenerative disorders.
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Impact
Karin et al., San Diego, United States. In Cell Metab, 2012
Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6 kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic pathologies, including hepatosteatosis and insulin resistance.
Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling.
GeneRIF
Rostami et al., Philadelphia, United States. In J Neuroimmunol, 2012
This study demonstrated that IL-12 signaling plays a complex role during the induction of tolerance as the presence of exogenous IL-12 and the lack of IL-12 signaling both prevent complete induction of tolerance.
Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.
GeneRIF
Kirsch et al., New York City, United States. In J Biol Chem, 2012
AnxA6 via its stimulatory actions on PKCalpha and its role in mediating Ca(2+) flux across membranes regulates terminal differentiation and mineralization events of chondrocytes.
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
GeneRIF
Siraganian et al., Bethesda, United States. In J Biol Chem, 2012
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.
GeneRIF
Orr et al., Shreveport, United States. In Arterioscler Thromb Vasc Biol, 2012
Implicate EphA2 as a novel proinflammatory mediator and potential regulator of atherosclerotic plaque development.
Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling.
GeneRIF
Gaus et al., Sydney, Australia. In Iubmb Life, 2011
the regulation of cell surface receptors by annexin A6 may be facilitated by its unique structure that allows recruitment of interaction partners and simultaneously bridging specialized membrane domains with cortical actin surrounding activated receptors
Royalactin induces queen differentiation in honeybees.
Impact
Kamakura, Toyama, Japan. In Nature, 2011
Mechanistic studies revealed that royalactin activated p70 S6 kinase, which was responsible for the increase of body size, increased the activity of mitogen-activated protein kinase, which was involved in the decreased developmental time, and increased the titre of juvenile hormone, an essential hormone for ovary development.
Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1.
Impact
Huang et al., Baltimore, United States. In Nat Med, 2010
Man(51)-BSA selectively targeted LPDCs that expressed SIGNR1 and induced the expression of interleukin-10 (IL-10), but not IL-6 or IL-12 p70.
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis.
Impact
Schwartz et al., United States. In Cell Metab, 2008
p70 S6 kinase 1 (S6K) is a major downstream effector of the mammalian target of rapamycin (mTOR), primarily implicated in the control of protein synthesis, cell growth, and proliferation.
Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
Impact
Pulendran et al., Atlanta, United States. In Nat Immunol, 2008
Inhibition of mTOR or its 'downstream' mediators, the p70 ribosomal S6 protein kinases p70S6K1 and p70S6K2, during pDC activation by Toll-like receptor 9 (TLR9) blocked the interaction of TLR9 with the adaptor MyD88 and subsequent activation of the interferon-regulatory factor IRF7, which resulted in impaired IFN-alpha/beta production.
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