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Islet cell autoantigen 1, 69kDa

p69, ICA69, ICA1
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, Autoantigen, ACID, CAN, HAD
Papers on p69
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A.
New
Fusi et al., Siena, Italy. In Br J Pharmacol, Jan 2016
As only few drugs stimulate ICa1.2 , this study was designed to analyse the effects of MuA on vascular Cav 1.2 channels.
Discover hidden splicing variations by mapping personal transcriptomes to personal genomes.
New
Xing et al., Los Angeles, United States. In Nucleic Acids Res, Jan 2016
These involve genes whose splicing variations have been implicated in diseases (such as OAS1), as well as novel associations between alternative splicing and diseases (such as ICA1).
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
New
Xia et al., Hong Kong, Hong Kong. In J Cell Sci, Nov 2015
Here, we identified ICA1L, which has sequence similarities to ICA69 (also known as ICA1), as a new BAR-domain binding partner of PICK1.
Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at High Temperatures in Arabidopsis thaliana.
New
Balasubramanian et al., Australia. In Plos Genet, May 2015
Positional cloning and characterization of the underlying gene revealed that ICARUS1 (ICA1), which encodes a protein of the tRNAHis guanylyl transferase (Thg1) superfamily, is required for plant growth at high temperatures.
Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw.
New
Wang et al., Wenzhou, China. In Neurochem Res, Mar 2015
Islet-cell autoantigen 69 kDa (ICA69) plays an important role in many diseases and physiological activities by forming heteromeric complexes with protein interacts with C-kinase 1 (PICK1).
Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome.
Arcos-Burgos et al., Canberra, Australia. In J Transl Med, 2014
RESULTS: Eleven novel and rare functional variants were identified in cases but not in controls, harboured in: MACF1, KIAA0754, DUSP12, ICA1, CELA1, LRP1/STAT6, GRIN3B, ANKLE1, TMEM161A, and FKRP.
Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis.
Zehner et al., Richmond, United States. In Plos One, 2014
A combinatorial approach was used to identify miRs that promote prostate cancer progression in a unique set of prostate cancer cell lines, which originate from the parental p69 cell line and extend to a highly tumorigenic/metastatic M12 subline.
A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice.
Webby et al., Saint Louis, United States. In Bmc Genomics, 2013
Sequence and RNA expression analysis identified several candidate host genes containing missense mutations or deletions; Samd9l, Ica1, and Slc25a13.
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.
GeneRIF
Pietropaolo et al., Ann Arbor, United States. In J Biol Chem, 2012
polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells.
Islet autoantigens: structure, function, localization, and regulation.
Review
Rhodes et al., Ann Arbor, United States. In Cold Spring Harb Perspect Med, 2011
In this context, we evaluate the biochemical nature and immunogenicity of the major autoantigens in T1D including (pro)insulin, GAD65, ZnT8, IA2, and ICA69.
Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.
GeneRIF
Yagil et al., Ashqelon, Israel. In Physiol Genomics, 2010
Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
GeneRIF
Solimena et al., Dresden, Germany. In Eur J Cell Biol, 2008
ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins
PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.
GeneRIF
Xia et al., Hong Kong, Hong Kong. In J Neurosci, 2007
Islet cell autoantigen 69 kDa (ICA69) regulates AMPA receptor trafficking by preventing formation of homomeric protein interacting with C kinase 1 (PICK1) Bin/amphiphysin/Rvs (BAR) domain complexes.
Metabolic and genomic dissection of diabetes in the Cohen rat.
GeneRIF
Yagil et al., Ashqelon, Israel. In Physiol Genomics, 2007
Ica1, on chromosome 4, is a high priority candidate gene for the development of diet-induced diabetes in the Cohen rat.
Primary Sjögren's syndrome and deficiency of ICA69.
Impact
Dosch et al., Toronto, Canada. In Lancet, 2002
ICA69 is a self-antigen expressed in brain, pancreas, salivary, and lacrimal glands.
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
Impact
Patel et al., Miami, United States. In Nat Genet, 1997
Type 1, or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease associated with loss of tolerance to several pancreatic islet cell molecules, including insulin, glutamic acid decarboxylase (GAD), ICA69 and the tyrosine phosphatase IA-2 (refs 1-3).
T-cell responses to autoantigens in IDDM. The search for the Holy Grail.
Review
Roep, Leiden, Netherlands. In Diabetes, 1996
In the last few years, considerable progress has been made with regard to the identification and characterization of candidate autoantigens recognized by autoantibodies; several of these candidate autoantigens are recognized by T-cells, including insulin, GAD65 and GAD67, heat-shock protein 65 (hsp65), and islet-cell antigen 69 (ICA69).
A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus.
Impact
Dosch et al., Toronto, Canada. In N Engl J Med, 1992
Antibodies to this peptide react with p69, a beta-cell surface protein that may represent the target antigen for milk-induced beta-cell--specific immunity.
Measurement of ionized calcium in serum with ion-selective electrodes: a mature technology that can meet the daily service needs.
Review
Sena et al., In Clin Chem, 1986
Our use of two second-generation Ca2+ analyzers (Radiometer ICA1 and NOVA 8) made possible uninterrupted service as volume increased to 31 640 patient tests in 1985.
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