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Neutrophil cytosolic factor 2

p67phox, NCF2
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] (from NCBI)
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Top mentioned proteins: p47phox, Akt, Ros, p40phox, CAN
Papers on p67phox
7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils.
New
Santa-María et al., Sevilla, Spain. In Eur J Nutr, Jan 2016
These oxysterols also stimulated the cellular membrane translocation of the NADPH oxidase cytosolic components, p47phox and p67phox.
Chronic Granulomatous Disease: clinical, molecular and therapeutic aspects.
Review
New
Finocchi et al., Roma, Italy. In Pediatr Allergy Immunol, Jan 2016
CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA, NCF1, NCF2 or NCF4 genes encoding p22(phox) , p47(phox) , p67(phox) and p40(phox) , respectively.
Genetic disorders coupled to ROS deficiency.
Review
New
Knaus et al., Dublin, Ireland. In Redox Biol, Dec 2015
In particular, deficiency in phagocyte Nox2 oxidase function due to genetic variants (CYBB, CYBA, NCF1, NCF2, NCF4) has been recognized as a direct cause of chronic granulomatous disease (CGD), an inherited immune disorder.
Resveratrol Improved Flow-Mediated Outward Arterial Remodeling in Ovariectomized Rats with Hypertrophic Effect at High Dose.
New
Henrion et al., Angers, France. In Plos One, Dec 2015
In HF arteries from RESV37.5-treated rats relaxation was increased by superoxide reduction and markers of oxidative stress (p67phox, GP91phox) were higher than in the 2 other groups.
GWAS in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture.
New
Jacob et al., Irapuato, Mexico. In Arthritis Rheumatol, Dec 2015
Other known SLE loci associated were ITGAM, STAT4, TNIP1, NCF2 and IRAK1.
Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis.
New
Jiménez et al., Barcelona, Spain. In J Hepatol, Nov 2015
In addition, a marked reduction in mRNA expression of inflammatory cytokines (TNFα, IL1β, COX-2, iNOS), ET-1 and messengers related to oxidative (Epx, Ncf1, Ncf2) or endoplasmic reticulum (Atf3, Hspa5) stress signaling pathways was observed in the liver of rats receiving CeO2NPs.
Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release.
New
Wu et al., Harbin, China. In Eur Rev Med Pharmacol Sci, Oct 2015
In addition, the Rac1 activity in the myocardium and the expression levels of Rac1, p47phox and p67phox were measured by RT-PCR and western blot.
The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes.
New
Barthwal et al., Lucknow, India. In Cell Mol Immunol, Oct 2015
The present study investigated the role of interleukin-1 receptor-associated kinase (IRAK), extracellular signal-regulated kinase (ERK), p67phox and Nox-2 in TLR4- and TLR2-induced ROS generation during interleukin-1 beta (IL-1β) transcription, processing, and secretion.
Tempol, a Superoxide Dismutase-Mimetic Drug, Ameliorates Progression of Renal Disease in CKD Mice.
Gu et al., Shanghai, China. In Cell Physiol Biochem, 2014
Nx animals exhibited significantly elevated proinflammatory and profibrotic factors, activation of NF-κB, increased expression of NADPH oxidase related subunits (p47phox, p67phox, gp91phox), and elevated activation of TGF-β/Smad3, EGFR, MAPK signaling pathway.
Rac-1 as a new therapeutic target in cerebro- and cardio-vascular diseases.
Review
Vecchione et al., Israel. In Curr Drug Targets, 2013
Vascular NAD(P)H oxidase contains the membrane-bound subunits Nox1, Nox2 (gp91phox), Nox4 and p22phox, the catalytic site of the oxidase, and the cytosolic components p47phox and p67phox.
Chronic granulomatous disease: a 25-year patient registry based on a multistep diagnostic procedure, from the referral center for primary immunodeficiencies in Greece.
Review
Kanariou et al., Athens, Greece. In J Clin Immunol, 2013
Sixteen patients from 14 unrelated families had X-linked CGD (66.7 %), four had mutations in the NCF1 gene (19 %), and three, from two unrelated families, had mutations in NCF2 (9.5 %) [Corrected].
Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase.
Review
Khan et al., Columbus, United States. In J Pathol, 2013
NOX is a multi-component enzyme complex that consists of membrane-bound cytochrome b-558, which is a heterodimer of gp91phox and p22phox, cytosolic regulatory subunits p47phox and p67phox, and the small GTP-binding protein Rac1.
NADPH oxidase mediates depressive behavior induced by chronic stress in mice.
GeneRIF
Han et al., Seoul, South Korea. In J Neurosci, 2012
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH oxidasesubunit (67kDa) and the resultant metabolic oxidative stress.
Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.
GeneRIF
Jalili et al., Salt Lake City, United States. In Febs J, 2012
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4-/-) mice.
Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
GeneRIF
Zidovetzki et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
NCF2 is strongly associated with increased risk of childhood- and adult-onset systemic lupus erythematosus through a single nonsynonymous coding mutation (H389Q) in exon 12.
Stable accumulation of p67phox at the phagosomal membrane and ROS production within the phagosome.
GeneRIF
Nüsse et al., Orsay, France. In J Leukoc Biol, 2012
p67(phox) has a critical role to support for reactive oxygen species production on the level of individual phagosomes.
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.
GeneRIF
Vyse et al., London, United Kingdom. In Plos Genet, 2011
Association analysis identified five SLE susceptibility genes reaching genome-wide levels of significance : NCF2 ,IKZF1 ,IRF8 ,IFIH1 , and TYK2
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase.
Impact
Bokoch et al., Los Angeles, United States. In Nat Immunol, 2001
Mutational and biophysical analysis shows that Rac and p67phox independently regulate cytochrome b to catalyze the transfer of electrons from NADPH to FAD.
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.
Impact
Hall et al., London, United Kingdom. In Science, 1994
Activation of the NADPH oxidase requires the assembly of a multimolecular complex at the plasma membrane consisting of two integral membrane proteins, gp91phox and p21phox, and two cytosolic proteins, p67phox and p47phox.
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase.
Impact
Kwong et al., Bethesda, United States. In Science, 1992
Oxidase activity was reconstituted in vitro with only the purified oxidase proteins p47phox, p67phox, Rac-related guanine nucleotide (GTP)-binding proteins, and membrane-bound cytochrome b558.
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