Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPKmore suppliers
In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Antibodies specific for iNOS, COX-2, p50, p65, IκB-α, p-IκB-α, and goat anti-rabbit IgG-FITC were obtained from Santa Cruz Biotechnology (CA, USA), while antibodies ...
Telomerase directly regulates NF-κB-dependent transcription.
Singapore, Singapore. In Nat Cell Biol, Dec 2012
Telomerase directly regulates NF-κB-dependent gene expression by binding to the NF-κB p65 subunit and recruitment to a subset of NF-κB promoters such as those of IL-6 and TNF-α, cytokines that are critical for inflammation and cancer progression.
The role of NF-κB activation during protection against Leishmania infection.
Marburg an der Lahn, Germany. In Int J Med Microbiol, Oct 2012
Since the discovery of the five members of the NF-κB transcription factor family, RelA, c-Rel, RelB, p50 and p52, considerable progress has been made toward better understanding how the different NF-κB homo- and heterodimers regulate such distinct subsets of target genes.
Procyanidins and inflammation: molecular targets and health implications.
Tarragona, Spain. In Biofactors, Jul 2012
During early events in NF-κB signaling, procyanidins modulate Iκκ activity, and the cytoplasmic retention of p65:p50 NF-κB by the inhibition of IκB phosphorylation and proteasomal degradation, while at late stages, they affect the nuclear translocation of pro/anti-inflammatory NF-κB homo/hetero dimers and their subsequent binding to the promoter regions of target genes.
Role of disorder in IκB-NFκB interaction.
More papers using
Los Angeles, United States. In Iubmb Life, Jun 2012
Although the primary event, phosphorylation and subsequent ubiquitin-dependent degradation of IκBα, the inhibitor of the canonical NFκB (p50/p65), is reasonably well understood, the means whereby the activation is turned off by postinduction repression are less well understood.
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
In PLoS ONE, 2009
... phospho-IκBα, p38-MAPK, phospho-p38-MAPK (Thr180/Tyr182), p44/42 MAPK, phospho-p44/42 MAPK, SAPK/JNK, phospho-SAPK/JNK (T183/Y185), Histone H3 and NFκB p65 were from Cell Signaling Technology (Beverly, MA, USA) ... SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages.
In Environmental Health Perspectives, 2009
... from Cell Signaling Technology (Beverly, MA, USA); Antibodies against COX-2, Jun-B, Jun-D, c-Fos, Fra-1, and p65 from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ... Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differention
In Arthritis Research & Therapy, 2006
... electrophoretic mobility shift assay (EMSA) the following were used: NFκB consensus and mutant oligonucleotides, anti-NFκB p65(A)X (Santa Cruz Biotech, Santa Cruz, CA, USA), T4 Polynucleotide Kinase and Reaction Buffer (New England Biolabs Inc., Ipswich, MA, USA), ... Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
In PLoS ONE, 2004
... p-Akt (Ser473), CREB, p-CREB (Ser133), ERK1/2, p-ERK1/2 (Thr 202/Tyr 204), NF-κB p65, p-p65 (Ser276) and p-p65 (Ser536) were purchased from Cell Signaling Technology, Inc ... Signaling pathways responsible for cancer cell invasion as targets for cancer therapy.
In PLoS ONE, 2003
... and anti-rabbit IgG-conjugated horseradish peroxidase, rabbit polyclonal antibodies specific for p-MEK, MEK, p-ERK, ERK, p-p65, p65, CCR5 siRNA, control siRNA, control shRNA plasmid, and CCL5 shRNA plasmid were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ... Mechanism of steroid action and resistance in inflammation: Corticoisteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma
In Journal of Inflammation (London, England), 2002
... (Alexis, Lausen, Switzerland), CD95 monoclonal antibody (clone CH-11; Immunotech, Marseille, France), NF-kB p65 and acetyl-NF-kB p65 (Lys310) antibodies (Cell Signaling Technology, Inc., Danvers, USA), ... Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells.
In PLoS ONE, 2000
... the following sources: anti-mouse and anti-rabbit IgGs, Bcl-2, Bcl-xL, Bax, TRAIL, DR4, DR5, PPAR, NF-κB p65 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); p21, ... Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems.
In PLoS Pathogens, 2000
... (AC-74, Sigma), RIP1 (38, BD Transduction Laboratories), HA (16B12, Covance Inc.), HA (3F10, Roche), NF-κB p65 (F-6, Santa Cruz, or C22B4, Cell Signaling), LC3B (D11, Cell signaling), ... KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
In The Journal of Experimental Medicine, 1995
... Antibodies recognizing VCAM-1, intercellular cell adhesion molecule (ICAM)-1, p50, p65, IκB-α, phospho–IκB-α, and α-HA were purchased from Santa Cruz Biotechnology, Inc., p300 antibody (Labvision), ...