Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK
In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Antibodies specific for iNOS, COX-2, p50, p65, IκB-α, p-IκB-α, and goat anti-rabbit IgG-FITC were obtained from Santa Cruz Biotechnology (CA, USA), while antibodies ... SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages.more suppliers
In Environmental Health Perspectives, 2009
... from Cell Signaling Technology (Beverly, MA, USA); Antibodies against COX-2, Jun-B, Jun-D, c-Fos, Fra-1, and p65 from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action.
South Korea. In Int Immunopharmacol, 28 Oct 2015
Brazilin also decreased RANKL-induced expression of inflammatory mediator genes such as inducible nitric oxide synthase, iNOS; cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and inhibited extracellular signal-regulated kinases (ERK) and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) p65 phosphorylation in RANKL-stimulated RAW264.7 cells.
Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics.
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Los Angeles, United States. In Redox Biol, 18 Sep 2015
Moreover, tumor cells treated with exogenous NO donors resulted in the inhibition of NF-κΒ activity via S-nitrosylation of p50 and p65, inhibition of Snail (NF-κΒ target gene), inhibition of transcription repression by S-nitrosylation of YY1 and subsequent inhibition of epithelial-mesenchymal transition (EMT), induction of RKIP (inhibition of the transcription repressor Snail), and induction of PTEN (inhibition of the repressors Snail and YY1).
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
In PLoS ONE, 2009
... phospho-IκBα, p38-MAPK, phospho-p38-MAPK (Thr180/Tyr182), p44/42 MAPK, phospho-p44/42 MAPK, SAPK/JNK, phospho-SAPK/JNK (T183/Y185), Histone H3 and NFκB p65 were from Cell Signaling Technology (Beverly, MA, USA) ... Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differention
In Arthritis Research & Therapy, 2006
... electrophoretic mobility shift assay (EMSA) the following were used: NFκB consensus and mutant oligonucleotides, anti-NFκB p65(A)X (Santa Cruz Biotech, Santa Cruz, CA, USA), T4 Polynucleotide Kinase and Reaction Buffer (New England Biolabs Inc., Ipswich, MA, USA), ... Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
In PLoS ONE, 2004
... p-Akt (Ser473), CREB, p-CREB (Ser133), ERK1/2, p-ERK1/2 (Thr 202/Tyr 204), NF-κB p65, p-p65 (Ser276) and p-p65 (Ser536) were purchased from Cell Signaling Technology, Inc ... Signaling pathways responsible for cancer cell invasion as targets for cancer therapy.
In PLoS ONE, 2003
... and anti-rabbit IgG-conjugated horseradish peroxidase, rabbit polyclonal antibodies specific for p-MEK, MEK, p-ERK, ERK, p-p65, p65, CCR5 siRNA, control siRNA, control shRNA plasmid, and CCL5 shRNA plasmid were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ... Mechanism of steroid action and resistance in inflammation: Corticoisteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma
In Journal of Inflammation (London, England), 2002
... (Alexis, Lausen, Switzerland), CD95 monoclonal antibody (clone CH-11; Immunotech, Marseille, France), NF-kB p65 and acetyl-NF-kB p65 (Lys310) antibodies (Cell Signaling Technology, Inc., Danvers, USA), ... Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems.
In PLoS Pathogens, 2000
... (AC-74, Sigma), RIP1 (38, BD Transduction Laboratories), HA (16B12, Covance Inc.), HA (3F10, Roche), NF-κB p65 (F-6, Santa Cruz, or C22B4, Cell Signaling), LC3B (D11, Cell signaling), ... Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells.
In PLoS ONE, 2000
... the following sources: anti-mouse and anti-rabbit IgGs, Bcl-2, Bcl-xL, Bax, TRAIL, DR4, DR5, PPAR, NF-κB p65 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); p21, ... KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
In The Journal of Experimental Medicine, 1995
... Antibodies recognizing VCAM-1, intercellular cell adhesion molecule (ICAM)-1, p50, p65, IκB-α, phospho–IκB-α, and α-HA were purchased from Santa Cruz Biotechnology, Inc., p300 antibody (Labvision), ...