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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 2 receptor, gamma

p64, IL2RG, CD132, gammaC, SCIDX1
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Interleukin-2, CAN, HAD, NOD, CD25
Papers on p64
Homeostasis of IL-15 dependent lymphocyte subsets in the liver.
New
Ramanathan et al., Sherbrooke, Canada. In Cytokine, Feb 2016
UNASSIGNED: IL-15 is a member of the gamma chain family of cytokines (γc - CD132).
Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.
New
Impact
Duvic et al., Houston, United States. In Nat Genet, Dec 2015
IL32 and IL2RG were overexpressed in nearly all cases.
Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer.
New
Guan et al., Guiyang, China. In Plos One, Dec 2015
We detected 135 differently expressed proteins from the three cell lines using proteome technology, and 10 differential proteins common to the three cell lines were selected and identified by LC-MS/MS as well as verified by western blot: β-actin, L-lactate dehydrogenase (LDH), dihydrolipoamide dehydrogenase (DLD), pre-mRNA-processing factor 19 homolog (PRPF19), ATP synthase, calmodulin (CaM), p64 CLCP, Ran-specific GTPase-activating protein (RanGAP), P43 and calreticulin.
Profile of Inflammation-associated genes during Hepatic Differentiation of Human Pluripotent Stem Cells.
New
Arumugaswami et al., Los Angeles, United States. In Data Brief, Dec 2015
Furthermore, hepatic phase of cells expressed proinflammatory cytokines IL18 and IL32 as well as cytokine receptors IL18R1, IL1R1, IL1RAP, IL2RG, IL6R, IL6ST and IL10RB.
Oxidative stress inhibits distant metastasis by human melanoma cells.
New
Impact
Morrison et al., Dallas, United States. In Nature, Dec 2015
Here we studied human melanomas that differed in their metastasis histories in patients and in their capacity to metastasize in NOD-SCID-Il2rg(-/-) (NSG) mice.
Ozone-induced Nasal Type 2 Immunity in Mice is Dependent on Innate Lymphoid Cells.
New
Harkema et al., East Lansing, United States. In Am J Respir Cell Mol Biol, Dec 2015
In the present study we determined the role of innate lymphoid cells (ILCs) in the pathogenesis of ozone-induced eosinophilic rhinitis by using lymphoid-sufficient C57BL/6 mice, Rag2(-/-) mice that are devoid of T cells and B cells, and Rag2(-/-)Il2rg(-/-) mice that are depleted of all lymphoid cells including ILCs.
IL7R gene expression network associates with human healthy ageing.
Beekman et al., Leiden, Netherlands. In Immun Ageing, 2014
To further investigate the IL7R pathway in ageing, we identified the closest interacting genes to construct an IL7R gene network that consisted of IL7R and six interacting genes: IL2RG, IL7, TSLP, CRLF2, JAK1 and JAK3.
The expanding realm of endovascular neurosurgery: flow diversion for cerebral aneurysm management.
Review
Siddiqui et al., Buffalo, United States. In Methodist Debakey Cardiovasc J, 2014
Although the Pipeline Embolization Device (ev3-Covidien, Irvine, CA) is the only flow-diversion device approved by the Food and Drug Administration for use in the United States, others are commercially available in Europe and South America, including the Silk (Balt Extrusion, Montmorency, France), Flow-Redirection Endoluminal Device (FRED; MicroVention, Tustin, CA), Surpass (Stryker, Kalamazoo, MI), and p64 (Phenox, Bochum, Germany).
Lentiviral vectors for the treatment of primary immunodeficiencies.
Review
Aiuti et al., Roma, Italy. In J Inherit Metab Dis, 2014
In this review, we describe the recent advancements achieved both in vitro and at preclinical level with LVVs for the treatment of Wiskott-Aldrich syndrome (WAS), chronic granulomatous disease (CGD), ADA deficiency (ADA-SCID), Artemis deficiency, RAG1/2 deficiency, X-linked severe combined immunodeficiency (γchain deficiency, SCIDX1), X-linked lymphoproliferative disease (XLP) and immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.
Targeted genome editing in human repopulating haematopoietic stem cells.
Impact
Naldini et al., Milano, Italy. In Nature, 2014
We demonstrate the therapeutic potential of our strategy by targeting a corrective complementary DNA into the IL2RG gene of HSCs from healthy donors and a subject with X-linked severe combined immunodeficiency (SCID-X1).
Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera.
Review
Kovar et al., Praha, Czech Republic. In Immunol Lett, 2014
IL-2 and IL-15 are structurally relative cytokines that share two receptor subunits, CD132 (γ(c) chain) and CD122 (β chain).
Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
Impact
Umetsu et al., Boston, United States. In Nat Med, 2014
AHR was also associated with the expansion of CCR6(+) type 3 innate lymphoid cells (ILCs) producing IL-17A (ILC3 cells) in the lung, which could by themselves mediate AHR when adoptively transferred into Rag2(-/-); Il2rg(-/-) mice treated with recombinant IL-1β.
Modeling normal and malignant human hematopoiesis in vivo through newborn NSG xenotransplantation.
Review
Ishikawa, Yokohama, Japan. In Int J Hematol, 2013
NOD/SCID mice harboring complete null mutation of Il2rg (NSG mice) lack T cells, B cells, and NK cells, and support high levels of engraftment by human cord blood hematopoietic stem cells (CB HSCs) and acute myeloid leukemia stem cells (AML LSCs).
Gene therapy for primary immunodeficiencies: Part 1.
Review
Aiuti et al., Paris, France. In Curr Opin Immunol, 2012
Over 60 patients affected by SCID due to IL2RG deficiency (SCID-X1) or adenosine deaminase (ADA)-SCID have received hematopoietic stem cell gene therapy in the past 15 years using gammaretroviral vectors, resulting in immune reconstitution and clinical benefit in the majority of them.
Il2rg gene-targeted severe combined immunodeficiency pigs.
Impact
Onishi et al., Tsukuba, Japan. In Cell Stem Cell, 2012
Fibroblasts containing a targeted disruption of the X-linked interleukin-2 receptor gamma chain gene, Il2rg, were used as donors to generate cloned pigs by serial nuclear transfer.
Role of the common γ chain in cell cycle progression of human malignant cell lines.
GeneRIF
Pignata et al., Napoli, Italy. In Int Immunol, 2012
the amount of the gamma-chain transducing element is able to influence the transcription of genes involved in cell cycle progression, thus being directly involved in the regulatory control of cell proliferation of malignant hematopoietic cell
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo.
GeneRIF
Notarangelo et al., Boston, United States. In Blood, 2012
Data imply that IL-21-mediated signaling is critical for long-lived humoral immunity and to restore antibody responses in IL2RG/JAK3-deficient patients after hematopoietic cell transplantation.
A novel mutation in CD132 causes X-CID with defective T-cell activation and impaired humoral reactivity.
GeneRIF
van Lier et al., In J Allergy Clin Immunol, 2011
We report a novel X-CID family with a unique mutation in the extracellular part of CD132 with almost normal T-cell counts but defective memory induction
Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway.
GeneRIF
Eid et al., Villejuif, France. In Plos One, 2011
These data highlight the central role of IL-15 and gammac-receptor signaling in renal homeostasis.
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.
GeneRIF
Wasik et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2011
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.
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