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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor protein p63

p63, p40, RPE65
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, cytokeratin, p53, HAD, IL-12
Papers using p63 antibodies
Module map of stem cell genes guides creation of epithelial cancer stem cells.
Supplier
Waalkes Michael P. et al., In Environmental Health Perspectives, 2007
... horse serum (room temperature, 1 hr), incubated with primary antibodies [rabbit anti-K5 (ABcam, Cambridge, MA), mouse anti-p63 (Santa Cruz Biotechnology, Santa Cruz, CA) or ...
A case of primary small cell carcinoma of the breast
Supplier
Bergkvist Leif et al., In Pathology Research International, 2006
... e-cadherin (Dako, clone NCH-38, 1 : 50), vimentin (Dako, clone Vim3B4, 1 : 600), calponin (Dako, clone CALP1, 1 : 600), p63 (Biocare Medical, clone BC4A4, 1 : 100), CD10 ...
Beta-catenin and E-cadherin expression in salivary gland tumors
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Manni J. J. et al., In European Archives of Oto-Rhino-Laryngology, 2005
... 1:500, DAKO), S100 protein (1:5,000, DAKO) and Alfa smooth muscle actin (clone 1A4, 1:1000, Sigma), p63 (Clone 4A4, DAKO).
The influence of chronic inflammation in prostatic carcinogenesis: a 5-year follow-up study
Supplier
Man Yan-Gao et al., In International Journal of Biological Sciences, 2005
... were subjected to double immunohistochemistry with basal cell phenotypic markers p63 (clone: 4A4; Cell Marque, Foster City, CA) at ...
Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures.
Supplier
Vongthongsri Anun et al., In Molecular Vision, 2003
... Mouse anti-human connexin 43, nerve growth factor (NGF) receptor (p75), ATP-binding cassette member 2 (ABCG2), and p63 antibodies were from BD Biosciences.
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Papers on p63
Prognostic significance of CD44v6, p63, Podoplanin, and MMP-9 in oral squamous cell carcinomas.
New
Warnakulasuryia et al., Portugal. In Oral Dis, Feb 2016
OBJECTIVES: To analyse the expression of the CD44v6, p63, podoplanin and MMP-9, and their prognostic significance in patients with oral squamous cell carcinomas (OSCC).
Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat.
New
Harada et al., In J Vet Med Sci, Feb 2016
The neoplastic cells tested immunopositive for keratin, vimentin, glial fibrillary acidic protein and p63.
p-Cresyl sulfate suppresses lipopolysaccharide-induced anti-bacterial immune responses in murine macrophages in vitro.
New
Kaneko et al., Kunitachi, Japan. In Toxicol Lett, Feb 2016
pCS significantly decreased interleukin (IL)-12 p40 production and increased IL-10 production.
Ustekinumab for the treatment of Crohn's disease: can it find its niche?
Review
New
Moran et al., Calgary, Canada. In Therap Adv Gastroenterol, Jan 2016
Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin (IL) 12 and 23, is a novel pharmacotherapy for this patient cohort that offers an out-of-class option.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
New
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63.
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.
Review
New
Tucker et al., Iowa City, United States. In Stem Cells Transl Med, Jan 2016
The recent success of gene augmentation trials for the treatment of RPE65-associated Leber congenital amaurosis has underscored the need for model systems that accurately recapitulate disease.
Chronic Granulomatous Disease: clinical, molecular and therapeutic aspects.
Review
New
Finocchi et al., Roma, Italy. In Pediatr Allergy Immunol, Jan 2016
CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA, NCF1, NCF2 or NCF4 genes encoding p22(phox) , p47(phox) , p67(phox) and p40(phox) , respectively.
DNA repair and aging: the impact of the p53 family.
Review
New
Raschellà et al., Roma, Italy. In Aging (albany Ny), Jan 2016
Among the key factors of the DDR, the related proteins p53, p63 and p73, all belonging to the same family of transcription factors, play multiple relevant roles.
ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion.
New
Liao et al., Taipei, Taiwan. In Plos One, Dec 2015
p63 is a member of the p53 transcription factor family and a linchpin of epithelial development and homeostasis.
Future perspectives in target-specific immunotherapies of myasthenia gravis.
Review
New
Dalakas, Philadelphia, United States. In Ther Adv Neurol Disord, Nov 2015
Novel biological agents currently on the market, directed against the following molecular pathways, are relevant and specific therapeutic targets that can be tested in MG: (a) T cell intracellular signaling molecules, such as anti-CD52, anti-interleukin (IL) 2 receptors, anti- costimulatory molecules, and anti-Janus tyrosine kinases (JAK1, JAK3) that block the intracellular cascade associated with T-cell activation; (b) B cells and their trophic factors, directed against key B-cell molecules; (c) complement C3 or C5, intercepting the destructive effect of complement-fixing antibodies; (d) cytokines and cytokine receptors, such as those targeting IL-6 which promotes antibody production and IL-17, or the p40 subunit of IL-12/1L-23 that affect regulatory T cells; and (e) T and B cell transmigration molecules associated with lymphocyte egress from the lymphoid organs.
Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
New
Impact
Towne et al., Seattle, United States. In Immunity, Nov 2015
Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn's disease.
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.
Review
New
Impact
Cua et al., Australia. In Nat Med, Jul 2015
Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation.
TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer.
New
Impact
Ellisen et al., Danvers, United States. In J Clin Oncol, Jul 2015
Coprimary end points were objective response rate (RR) and response prediction by p63/p73 gene expression.
Long-term effect of gene therapy on Leber's congenital amaurosis.
New
Impact
Ali et al., Durham, United Kingdom. In N Engl J Med, Jun 2015
BACKGROUND: Mutations in RPE65 cause Leber's congenital amaurosis, a progressive retinal degenerative disease that severely impairs sight in children.
Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations.
New
Impact
Rajagopal et al., Boston, United States. In Cell Stem Cell, Mar 2015
Current models of airway epithelial regeneration propose that distinct cytokeratin 8-expressing progenitor cells, arising from p63(+) basal stem cells, subsequently differentiate into secretory and ciliated cell lineages.
Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.
GeneRIF
Redmond et al., Bethesda, United States. In J Biol Chem, 2012
Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.
The p63 protein isoform ΔNp63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes.
GeneRIF
Calabrò et al., Napoli, Italy. In J Biol Chem, 2012
DeltaNp63alpha affects cell movement and can reverse the increase of cell motility induced by YB-1 overexpression.
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.
GeneRIF
Chung et al., Seoul, South Korea. In J Clin Invest, 2012
ISG15 as a tumor suppressor via its conjugation to a tp63 splice variant
DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53.
GeneRIF
Zhang et al., Chengdu, China. In Biochem Biophys Res Commun, 2012
these data suggest that DNA damage down-regulates DeltaNp63alpha, which may directly contribute to DNA damage-induced apoptosis.
Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.
GeneRIF
Ratovitski et al., Baltimore, United States. In Cell Cycle, 2012
Phosphorylated p63 binds to the splicing complex leading to repression of mRNA splicing and activation of ACIN1-mediated cell death pathway.
More papers using p63 antibodies
Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases
Supplier
Man Yan-gao et al., In International Journal of Biological Sciences, 2003
... Mouse monoclonal antibodies against human WT-1 protein (clone: 6F-H2) and p63 protein (clone: 4A4) were purchased from Cell Marque (Hot Springs, AR) ...
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
Supplier
Proost Paul, In PLoS ONE, 2002
... Serum IL-17A and IL-23 (p19/p40) were measured by ELISA (eBioscience, San Diego, USA) ...
Assessment of cellular profile and lung function with repeated bronchoalveolar lavage in individual mice
Supplier
Wang Xiao-Jing et al., In International Journal of Biological Sciences, 1999
... incubated overnight at 4°C with antibodies against Keratin 5 (1:500 Abcam, Cambridge, MA), K14 (1:1000, Abcam), p63 (1:50 Santa Cruz Biotechnology, Santa Cruz, CA), or ...
Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs
Supplier
Holtzman Michael J. et al., In The Journal of Experimental Medicine, 1986
... IL-12 pAb were from R&D Systems; rabbit anti–human IL-12 p35 Ab and goat anti–mouse IL-12 p40 Ab were from Santa Cruz Biotechnology, Inc.; rat anti–IL-12 p40 ...
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