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Ubiquitin protein ligase E3 component n-recognin 4

P600
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, V1a, Adenylate Cyclase, LC3
Papers on P600
p600/UBR4 in the central nervous system.
Review
New
Nguyen et al., Calgary, Canada. In Cell Mol Life Sci, Mar 2015
A decade ago, the large 600 kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in anoikis, viral transformation and protein degradation.
p600 stabilizes microtubules to prevent the aggregation of CaMKIIα during photoconductive stimulation.
Nguyen et al., Calgary, Canada. In Cell Mol Biol Lett, 2014
The large microtubule-associated/Ca(2+)-signalling protein p600 (also known as UBR4) is required for hippocampal neuronal survival upon Ca(2+) dyshomeostasis induced by glutamate treatment.
p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex.
Nguyen et al., Calgary, Canada. In Biol Open, 2013
Using knockout and in utero electroporation mouse models, we report a key role for the microtubule-associated protein 600 (p600) in the regulation of spindle orientation in aNPs, a cellular event that has been associated with cell fate and neurogenesis.
A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600.
Nguyen et al., Calgary, Canada. In J Biol Chem, 2013
We now report that the microtubule-associated protein p600 (also known as UBR4) promotes neuronal survival.
The N-end rule proteolytic system in autophagy.
Kwon et al., Pittsburgh, United States. In Autophagy, 2013
Our earlier work identified UBR4/p600 as one of the N-recognins that promotes N-degron-dependent proteasomal degradation.
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.
Kwon et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2013
Our previous studies identified the mammalian N-recognin family consisting of UBR1/E3α, UBR2, UBR4/p600, and UBR5, which recognize destabilizing N-terminal residues through the UBR box.
Interactions between E6AP and E6 proteins from alpha and beta HPV types.
Banks et al., Trieste, Italy. In Virology, 2013
These include the E3 ubiquitin-protein ligases E6AP and UBR4/p600.
Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?
Borzacchiello et al., Napoli, Italy. In Infect Agent Cancer, 2012
Additionally, E7 is involved in cell-mediated immune responses leading to tumour rejection, in anoikis process by direct binding to p600, and in invasion process by upregulation of Matrix metalloproteinase1 (MMP-1) expression.
p600 Plays Essential Roles in Fetal Development.
Nakatani et al., Tokyo, Japan. In Plos One, 2012
p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis.
Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.
Howley et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Binding of E7 to UBR4/p600 is conserved across all virus types, whereas the cellular protein ENC1 binds specifically to the E7s from HPV18 and HPV45, both members of genus alpha, species 7. We identify a specific interaction of HPV16 E7 with ZER1, a substrate specificity factor for a cullin 2 (CUL2)-RING ubiquitin ligase, and show that ZER1 is required for the binding of HPV16 E7 to CUL2.
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.
Iwatsubo et al., Tokyo, Japan. In Biochem J, 2012
It has been proposed that LRRK2 predominantly exists as a homodimer on the basis of the observation that LRRK2, with a theoretical molecular mass of 280 kDa, migrates at 600 kDa (p600 LRRK2) on native polyacrylamide gels.
Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer.
Tanaka et al., Fukuoka, Japan. In Ann Surg Oncol, 2011
p600 (600-kDa protein), recently identified from a cervical cancer cell line, plays a role in both anoikis resistance and cell migration.
Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting.
Nakamura et al., Kyoto, Japan. In Acta Biomater, 2011
Selective laser melting was employed to fabricate porous Ti implants (diameter 3.3mm, length 15 mm) with a channel structure comprising four longitudinal square channels, representing pores, of different diagonal widths, 500, 600, 900, and 1200 μm (termed p500, p600, p900, and p1200, respectively).
Bovine papillomavirus E7 oncoprotein binds to p600 in naturally occurring equine sarcoids.
Borzacchiello et al., Napoli, Italy. In J Gen Virol, 2011
Here, we show that the interaction between the 600 kDa retinoblastoma protein-associated factor (p600) and BPV E7, described in vitro in cultured cells, takes place in vivo in naturally occurring equine sarcoids.
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.
Goldberg et al., Boston, United States. In Biochemistry, 2009
In addition, we identified over 40 proteins not previously known to associate with the 26S proteasome, some of which were tightly associated with the proteasome in a substoichiometric fashion, e.g., the deubiquitinating enzymes USP5/isopeptidase T and USP7/HAUSP and the ubiquitin ligases ARF-BP1/HUWE1 and p600/UBR4.
Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons.
GeneRIF
Nguyen et al., Calgary, Canada. In J Neurosci, 2008
This study identified protein 600 (p600) as a novel microtubule-associated protein (MAP) developmentally regulated in neurons. p600 exhibits the unique feature to interact with the endoplasmic reticulum (ER).
p600, a unique protein required for membrane morphogenesis and cell survival.
GeneRIF
Herlitz et al., Boston, United States. In Proc Natl Acad Sci U S A, 2005
Results identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein.
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
GeneRIF
Münger et al., Boston, United States. In Proc Natl Acad Sci U S A, 2005
p600 is a cellular target of the human papillomavirus type 16 E7 oncoprotein that regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation.
Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding.
GeneRIF
Howley et al., Boston, United States. In Proc Natl Acad Sci U S A, 2005
Found murine p600 (formally called RBAF600) copurified with the E7 oncoprotein in C127 cells. This interaction was found to correlate with the ability of E7 to increase transformation.
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
GeneRIF
Kwon et al., Pittsburgh, United States. In Mol Cell Biol, 2005
Member of UBR box protein family, termed Ubr4. Binds to destabilizing N-terminal residues of N-end rule substrates. Participates in degradation of N-end rule substrates.
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