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Tumor protein p53 regulated apoptosis inducing protein 1

p53AIP1, p53-regulated apoptosis-inducing protein 1
This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: p53, p73, PrP, p21, mdm2
Papers on p53AIP1
[Effect of p53-regulated apoptosis-inducing protein 1 transfection on the biological characteristics of PC-3M human prostate cancer cells].
Yu et al., Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2014
OBJECTIVE: To investigate the effect of p53-regulated apoptosis-inducing protein 1 (p53AIP1) gene on the proliferation, cell cycle, apoptosis, invasion and migration of PC-3M human prostate cancer cells in vitro.
Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction.
Wang et al., Nanjing, China. In Biophys J, 2014
In parallel, miR-34a promotes apoptosis by enhancing the accumulation of free p53AIP1, a key proapoptotic protein.
Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A.
Ishihara et al., Kurashiki, Japan. In Clin Immunol, 2014
P53R248Q dramatically suppressed the expression of the pro-apoptotic molecule p53AIP1 even under oxidative stress, which normally upregulates p53AIP1, leading to apoptosis.
Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model.
Nishida et al., In Arthritis Res Ther, 2013
Although the percentage of cells immunopositive for cleaved caspase-8, a marker of apoptosis initiation through the death-receptor pathway, increased only at day 7, the percentage of cells immunopositive for cleaved caspase-9 and p53-regulated apoptosis-inducing protein 1 (p53AIP1), markers of apoptosis initiation through the p53-mediated mitochondrial pathway, increased from day 7 through day 56.
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.
Fujii et al., Tokyo, Japan. In Plos One, 2013
Concomitantly with the decreased phosphorylation level of MDM2 (mouse double minute 2 homolog), the level of phosphorylation of TP53 at Ser46 was increased by DS-7423 in the six cell lines with wild-type TP53, with induction of genes that mediate TP53-dependent apoptosis, including p53AIP1 and PUMA at 39 nM or higher doses.
Genetic variation in the TP53 pathway and bladder cancer risk. a comprehensive analysis.
Malats et al., Madrid, Spain. In Plos One, 2013
RESULTS: Based on classical analyses, SNPs in BAK1 (1), IGF1R (5), P53AIP1 (1), PMAIP1 (2), SERINPB5 (3), TP63 (3), and TP73 (1) showed significant associations at p-value≤0.05.
[Construction and identification of a recombinant replication-defective adenovirus vector encoding p53AIP1 and its expression in human HeLa cells].
Yu et al., Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2013
OBJECTIVE: To construct a recombinant replication-defective adenovirus vector carrying p53AIP1 (p53-regulated apoptosis-inducing protein 1) gene and observe its expression in human HeLa cells.
Altered binding site selection of p53 transcription cassettes by hepatitis B virus X protein.
Lee et al., Singapore, Singapore. In Mol Cell Biol, 2013
Using an HBx-deregulated gene, p53AIP1, as a model, we show that HBx aberrantly increases p53AIP1 expression by conferring p53 selectivity for a more conserved binding site in its regulatory region.
A novel approach to cancer treatment using structural hybrids of the p53 gene family.
Tokino et al., Sapporo, Japan. In Cancer Gene Ther, 2012
The p63-53O hybrid efficiently transactivated p53AIP1.
Beyond pancreatic carcinoma: The close relationship between survivin levels and prognosis in systemic malignancies.
Kapoor, Mechanicsville, United States. In World J Clin Oncol, 2012
In fact, Yamashita et al have shown that when used in combination with p53AIP1, survivin is a powerful prognostic indicator in non-small cell lung carcinomas.
Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.
GeneRIF
Zhang et al., Hefei, China. In Embo Rep, 2012
Apak competes with p53 for binding to inhibit p53AIP1 expression.
Prostate cancer risk is not altered by TP53AIP1 germline mutations in a German case-control series.
GeneRIF
Maier et al., Ulm, Germany. In Plos One, 2011
large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition
Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions.
Lu et al., Beijing, China. In Exp Ther Med, 2010
We generated replication-defective adenovirus Ad-p53AIP1 and studied its anti-tumor efficacy both in vitro and in vivo.
Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer.
GeneRIF
Kawahara et al., Ōita, Japan. In J Exp Clin Cancer Res, 2008
Data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population.
Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.
GeneRIF
Fukuda et al., Hirosaki, Japan. In J Clin Gastroenterol, 2008
Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection.
Insights in gastric carcinogenesis from Helicobacter pylori infection.
GeneRIF
Daniele, In J Clin Gastroenterol, 2008
Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection.
Arsenic trioxide in hematological malignancies: the new discovery of an ancient drug.
Review
Lunghi et al., Parma, Italy. In Curr Pharm Biotechnol, 2006
By combining ATO with specific MEK inhibitors, we demonstrated that the block of MEK-ERK phosphorylation, the induction of Bad de-phosphorylation, and activation of p53AIP1 apoptotic pathway interrupt the pro-survival mechanisms of ATO and kill the leukemic cells by apoptotic synergism.
Isolation of p53-target genes and their functional analysis.
Review
Nakamura, Tokyo, Japan. In Cancer Sci, 2004
The physiological functions of p53-target genes include apoptosis (GML, p53AIP1, and STAG1), DNA repair (p53R2), inhibition of angiogenesis (BAI1), re-entry into the cell cycle (p53RFP), oxidative stress (CSR), and determination of cell fate (p53RDL1).
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Impact
Taya et al., Tokyo, Japan. In Cell, 2000
Through direct cloning of p53 binding sequences from human genomic DNA, we have isolated a novel gene, designated p53AIP1 (p53-regulated Apoptosis-Inducing Protein 1), whose expression is inducible by wild-type p53.
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