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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of

P52rIPK, PRKRIR, DAP4, THAP0, P58IPK-interacting protein, Death-associated protein 4, DLP4, DLGAP4
The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, apolipoprotein B, Insulin, AGE, PKR
Papers on P52rIPK
Epigenome-wide association analysis identified nine skin DNA methylation loci for psoriasis.
New
Zhang et al., Hefei, China. In J Invest Dermatol, Jan 2016
The expression of CYP2S1, ECE1, EIF2C2, MAN1C1 and DLGAP4 was negatively correlated with DNAm.
Purification and characterization of a novel antibacterial peptide from black soldier fly (Hermetia illucens) larvae.
New
Yoe et al., Ch'ŏnan, South Korea. In Dev Comp Immunol, Sep 2015
The immunized hemolymph was extracted, and the novel defensin-like peptide 4 (DLP4) was purified using solid-phase extraction and reverse-phase chromatography.
Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia.
Silahtaroglu et al., Copenhagen, Denmark. In Hum Mol Genet, 2015
To understand the genetic-epigenetic interplay at breakpoints of chromosomal translocations disrupting CG-rich loci, we quantified epigenetic modifications at DLGAP4 (SAPAP4), a key post-synaptic density 95 (PSD95) associated gene, truncated by the chromosome translocation t(8;20)(p12;q11.23),
Positive association of adiponectin with soluble thrombomodulin, von Willebrand factor and soluble VCAM-1 in dyslipidemic subjects.
Frohlich et al., Olomouc, Czech Republic. In Clin Biochem, 2013
Subjects were divided into 4 dyslipidemic phenotypes (DLP): DLP1 (TG < 1.5 mmol/L + ApoB < 1.2 g/L), DLP2 (TG ≥ 1.5 + ApoB < 1.2), DLP3 (TG < 1.5 + ApoB ≥ 1.2) and DLP4 (TG ≥ 1.5 + ApoB ≥ 1.2).
Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness.
Novotny et al., Olomouc, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2013
METHODS: 667 clinically asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n=198, normo-apoB/normo-TG), DLP2 (n=179, normo-apoB/hyper-TG), DLP3 (n=87, hyper-apoB/normo-TG), DLP4 (n=203, hyper-apoB/hyper-TG). DLP1 served as a control group.
Sequence and expression analysis of gaps in human chromosome 20.
Silahtaroglu et al., Copenhagen, Denmark. In Nucleic Acids Res, 2012
All three gaps are within gene-dense regions and/or overlap disease-associated loci, including the DLGAP4 locus.
Soluble intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in asymptomatic dyslipidemic subjects.
Lukes et al., Olomouc, Czech Republic. In Int Angiol, 2011
g/L and TG<1.5 mmol/L) and DLP4 (N.=98, apoB≥1.2
A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein.
GeneRIF
Yoo et al., South Korea. In Biochem Biophys Res Commun, 2011
PRKRIR provides a novel positive regulator controlling the RIG-I-IFN production system through protein stability control.
Total adiponectin levels in dyslipidemic individuals: relationship to metabolic parameters and intima-media thickness.
Novotny et al., Olomouc, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2011
g/l and TG<1.5 mmol/l) and DLP4 (n=98, apoB≥1.2
Prothrombotic markers in asymptomatic dyslipidemic subjects.
Novotny et al., Olomouc, Czech Republic. In J Thromb Thrombolysis, 2011
Individuals were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n = 58, apoB < 1.2 g/l and TG < 1.5 mmol/l), DLP2 (n = 47, apoB < 1.2 g/l and TG ≥ 1.5 mmol/l), DLP3 (n = 31, apoB ≥ 1.2 g/l and TG < 1.5 mmol/l) and DLP4 (n = 98, apoB ≥ 1.2 g/l and TG ≥ 1.5 mmol/l).
The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.
Rosenstiel et al., Kiel, Germany. In J Immunol, 2010
We demonstrate that overexpression and enforced oligomerization of NLRC5 protein results in activation of the IFN-responsive regulatory promoter elements IFN-gamma activation sequence and IFN-specific response element and upregulation of antiviral target genes (e.g., IFN-alpha, OAS1, and PRKRIR).
Gene expression profile associated with superimposed non-alcoholic fatty liver disease and hepatic fibrosis in patients with chronic hepatitis C.
Baranova et al., Fairfax, United States. In Liver Int, 2009
On the other hand, models predicting hepatic steatosis in non-genotype 3 patients highlighted MIP-1 cytokine encoding genes: CCL3 and CCL4 as well as IFNAR and PRKRIR.
Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis.
Van Den Heuvel et al., Mol, Belgium. In Toxicology, 2009
The 10 most discriminative genes were BC042064, A_24_P229834, DOCK11, THC2544911, DLGAP4, NINJ1, PFKM, FLJ10986, IL28RA, and CASP9.
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays.
Wanker et al., Berlin, Germany. In Mol Cell Proteomics, 2006
Many novel interaction pairs such as valosin-containing protein/autocrine motility factor receptor, CHIP/caytaxin, or amphiphysin II/DLP4 were identified and subsequently confirmed by pull-down, two-hybrid and co-immunoprecipitation experiments.
Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli.
Morikawa et al., Nagaoka, Japan. In Protein Expr Purif, 2005
Nucleotide sequence analysis revealed an open reading frame of 2238bp, which was assigned to dap4 by N-terminal and internal amino acid sequences previously reported.
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.
GeneRIF
Avruch et al., Boston, United States. In J Biol Chem, 2003
role in promoting MST1-induced apoptosis by enabling colocalization of MST with p53
nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP).
GeneRIF
Takai et al., Suita, Japan. In J Biol Chem, 1999
Shows that an homologous rat protein can interact with nArgBP2, a novel neural member of the ponsin/ArgB/vinexin family.
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.
GeneRIF
Takai et al., Kōbe, Japan. In J Biol Chem, 1997
Includes the identification and characterization of an homologous protein in rat.
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