gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

p52, Lyt, LEDGF, NF-kappaB2
This gene encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. This gene encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor, depending on its dimer partner. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, May 2012] (from NCBI)
Top mentioned proteins: NF-kappaB, p65, p75, RelB, CAN
Papers using p52 antibodies
Functions of nuclear factor kappaB in bone.
Supplier
Agarwal Sudha, In PLoS ONE, 2009
... P65, P50 and P52 antibodies were purchased from Cell Signaling Technology (Danvers, MA) ...
Derivation of embryonic stem cell lines.
Supplier
Green Douglas R., In PLoS Biology, 1992
... Herman Chung and Bob Korneluk (Apoptosis Research Center, Children's Hospital of Eastern Ontario), anti-NIK and anti-p52 from Cell Signaling Technologies, anti-phospho-IκB and anti-IκB ...
Papers on p52
Different EGF Receptor Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Protein.
New
Pike et al., Washington, D.C., United States. In J Biol Chem, Feb 2016
To determine the basis for these differences, we used luciferase fragment complementation imaging to monitor the recruitment of Cbl, CrkL, Gab1, Grb2, PI3K, p52 Shc, p66 Shc and Shp2 to the EGF receptor when stimulated by the seven EGF receptor ligands.
p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment.
New
Blackwell et al., Nashville, United States. In J Immunol, Feb 2016
In lung tissue from patients with acute respiratory distress syndrome, we identified increased expression of the noncanonical pathway component p100/p52.
Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.
New
Fujii et al., Niigata, Japan. In Virus Genes, Feb 2016
One significant difference of Tax1 from Tax2 is the activation of transcription factor NF-κB2/p100/p52.
Mono-(2-Ethylhexyl) Phthalate Promotes Pro-Labor Gene Expression in the Human Placenta.
New
Rosen et al., New Brunswick, United States. In Plos One, Dec 2015
Placental corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2) are key mediators of parturition and are regulated by the non-canonical NF-kB (RelB/p52) signaling pathway.
LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.
New
Casiano et al., Loma Linda, United States. In Plos One, Dec 2015
LEDGF/p75, also known as the DFS70 autoantigen, is a stress transcription co-activator implicated in cancer, HIV-AIDS, and autoimmunity.
Nuclear architecture dictates HIV-1 integration site selection.
New
Impact
Lusic et al., Trieste, Italy. In Nature, Jun 2015
Functional viral integrase and the presence of the cellular Nup153 and LEDGF/p75 integration cofactors are indispensable for the peripheral integration of the virus.
MLL leukemia and future treatment strategies.
Review
New
Marschalek, Frankfurt am Main, Germany. In Arch Pharm (weinheim), Apr 2015
This leads to MLL-X fusion proteins that still bind to nuclear factors (e.g., MEN1, LEDGF), which in turn allow them to target promoters and cause ectopic gene transcription.
Host factors for retroviral integration site selection.
Review
New
Gijsbers et al., Leuven, Belgium. In Trends Biochem Sci, Feb 2015
HIV integrase (IN) is targeted to the body of active transcription units through interaction with lens epithelium-derived growth factor (LEDGF/p75).
Host Factors in Retroviral Integration and the Selection of Integration Target Sites.
Review
Bushman et al., In Microbiol Spectr, 2014
The cell transcriptional co-activator protein LEDGF/p75 has been identified as a tethering factor important for HIV integration, and recently, BET proteins (Brd2, 4, and 4) have been identified as tethering factors for the gammaretroviruses.
HIV-1 integrase multimerization as a therapeutic target.
Review
Kvaratskhelia et al., Columbus, United States. In Curr Top Microbiol Immunol, 2014
Cellular chromatin-associated protein LEDGF/p75 engages the IN tetramer in the SSC and directs HIV-1 integration into active genes.
Recent Advances in the Development of Small-Molecular Inhibitors Target HIV Integrase-LEDGF/p75 Interaction.
Review
Luo et al., Huainan, China. In Mini Rev Med Chem, 2014
Lens epithelium-derived growth factor (LEDGF/p75) plays an essential role in the HIV-1 replication.
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Impact
Siebenlist et al., Bethesda, United States. In Immunity, 2014
Bcl-3 is an atypical member of the IκB family that modulates transcription in the nucleus via association with p50 (NF-κB1) or p52 (NF-κB2) homodimers.
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways.
Impact
Hoffmann et al., San Diego, United States. In Nat Immunol, 2012
Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB pathway, but as a RelB-p50 dimer regulated by canonical IκBs, IκBα and IκBɛ.
Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response.
GeneRIF
Singh et al., Omaha, United States. In Febs J, 2012
findings provide insights into the regulation and regulatory functions of LEDGF in Sumoylation-dependent transcriptional control that may be essential for modifying the physiology of cells to maintain cellular homeostasis
LEDGF (p75) promotes DNA-end resection and homologous recombination.
GeneRIF
Jäättelä et al., Copenhagen, Denmark. In Nat Struct Mol Biol, 2012
Depletion of LEDGF impairs the recruitment of C-terminal binding protein interacting protein (CtIP) to DNA DSBs and the subsequent CtIP-dependent DNA-end resection.
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.
Impact
Ting et al., Chapel Hill, United States. In Immunity, 2012
NLRP12 interacted with both NIK and TRAF3, and Nlrp12(-/-) cells have constitutively elevated NIK, p100 processing to p52 and reduced TRAF3.
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Impact
Lei et al., Ann Arbor, United States. In Nature, 2012
A recent report on the tethering of MLL1 to chromatin binding factor lens epithelium-derived growth factor (LEDGF) by menin indicates that menin is a molecular adaptor coordinating the functions of multiple proteins.
Expression analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and tetherin in a Senegalese cohort of HIV-1-exposed seronegative individuals.
GeneRIF
Van Ostade et al., Antwerp, Belgium. In Plos One, 2011
reduced LEDGF/p75 levels may play a role in resistance to HIV-1 infection.
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.
GeneRIF
Bickmore et al., Edinburgh, United Kingdom. In Plos Genet, 2011
We propose that Psip1/p52, through its binding to both chromatin and splicing factors, might act to modulate splicing
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.
GeneRIF
Sangfelt et al., Stockholm, Sweden. In Nat Commun, 2011
Fbw7-mediated destruction of p100 is a regulatory component restricting the response to NF-kappaB2 pathway stimulation.
share on facebooktweetadd +1mail to friends