Different EGF Receptor Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Protein.
Washington, D.C., United States. In J Biol Chem, Feb 2016
To determine the basis for these differences, we used luciferase fragment complementation imaging to monitor the recruitment of Cbl, CrkL, Gab1, Grb2, PI3K, p52 Shc, p66 Shc and Shp2 to the EGF receptor when stimulated by the seven EGF receptor ligands.
MLL leukemia and future treatment strategies.
Frankfurt am Main, Germany. In Arch Pharm (weinheim), Apr 2015
This leads to MLL-X fusion proteins that still bind to nuclear factors (e.g., MEN1, LEDGF), which in turn allow them to target promoters and cause ectopic gene transcription.