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Prolyl 4-hydroxylase, alpha polypeptide II

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: P4HA1, HIF-1alpha, COL4A1, SET, COL2A1
Papers on P4HA2
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.
Roberts et al., Adelaide, Australia. In Eur J Cell Biol, Dec 2015
There was no difference in the expression level of any of the hypoxia responsive genes of interest, IGFBP3, P4HA1, P4HA2, ANGPTL4 and MMP1 between early and late first trimester placenta.
Prognostic and functional importance of the engraftment-associated genes in the patient-derived xenograft models of triple-negative breast cancers.
Noh et al., Seoul, South Korea. In Breast Cancer Res Treat, Nov 2015
Among the engraftment-related genes, PHLDA2, TKT, and P4HA2 showed high expression in triple-negative breast cancer cell lines, and siRNA-based gene silencing resulted in reduced cell invasion and proliferation in vitro.
Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.
Myllyharju et al., Oulu, Finland. In J Biol Chem, Aug 2015
To study the role of C-P4H-II, which predominates in chondrocytes, we generated P4ha2(-/-) mice.
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.
Semenza et al., Chongqing, China. In Oncotarget, Jun 2015
Inhibition of TAZ expression impairs the hypoxic induction of HIF-1 target genes, such as PDK1, LDHA, BNIP3 and P4HA2 in response to hypoxia, whereas inhibition of HIF-1α expression impairs TAZ-mediated transactivation of the CTGF promoter.
Mutations of P4HA2 encoding prolyl 4-hydroxylase 2 are associated with nonsyndromic high myopia.
Xia et al., Changsha, China. In Genet Med, Apr 2015
RESULTS: A heterozygous missense mutation, c.871G>A (p.Glu291Lys), within P4HA2 was cosegregating with the phenotype in the family.
Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I.
Clarke et al., Vancouver, Canada. In Mol Genet Metab, Feb 2015
Genome-wide expression studies in embryonic day 13.5 limb cartilage and 5 week growth plate cartilage followed by specific gene candidate qPCR studies in the 5week growth plate identified fourteen significantly deregulated mRNAs (Adamts12, Aspn, Chad, Col2a1, Col9a1, Hapln4, Lum, Matn1, Mmp3, Ogn, Omd, P4ha2, Prelp, and Rab32).
Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics.
Gautron et al., Ottawa, Canada. In Bmc Genomics, 2014
Genes encoding collagen-processing enzymes such as lysyl oxidase homologs 1, 2 and 3 (LOXL1, LOXL2 and LOXL3), prolyl 4 hydroxylase subunit α-2 and beta polypeptide (P4HA2 and P4HB) as well as peptidyl-prolyl cis-trans isomerase C (PPIC) were also over-expressed.
Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.
Xu et al., Lexington, United States. In Bmc Cancer, 2013
Collagen prolyl-4-hydroxylase α subunit 2 (P4HA2), an enzyme hydroxylating proline residues in -X-Pro-Gly- sequences, is a potential therapeutic target for the disorders associated with increased collagen deposition.
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
Semenza et al., Baltimore, United States. In J Biol Chem, 2013
HIF-1 activates expression of genes encoding collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD2) hydroxylases.
Helicase-like transcription factor (Hltf) regulates G2/M transition, Wt1/Gata4/Hif-1a cardiac transcription networks, and collagen biogenesis.
Chilton et al., Lubbock, United States. In Plos One, 2012
Hif-1a targets for prolyl (P4ha1, P4ha2) and lysyl (Plod2) collagen hydroxylation, PPIase enzymes (Ppid, Ppif, Ppil3) for collagen trimerization, and lysyl oxidase (Loxl2) for collagen-elastin crosslinking were downregulated.
The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma.
Crook et al., Ioánnina, Greece. In Br J Cancer, 2012
The C-P4Hs are tetrameric proteins comprising a variable α subunit, encoded by the P4HA1, P4HA2 and P4HA3 genes and a constant β subunit encoded by P4HB.
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
Shen et al., Nanjing, China. In Nat Genet, 2012
We also found consistent associations for rs247008 at 5q31.1 (IL3-CSF2-P4HA2, P = 7.68 × 10(-8)) and rs9439519 at 1p36.32 (AJAP1-NPHP4, P = 3.65 × 10(-6)).
Profiling and comparative analysis of glycoproteins in Hs578BST and Hs578T and investigation of prolyl 4-hydroxylase alpha polypeptide II expression and influence in breast cancer cells.
Bai et al., Tianjin, China. In Biochemistry (mosc), 2012
P4HA2 was upregulated in breast tumor cells compared with its adjacent normal tissues.
Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology.
Chi et al., Taiwan. In J Proteome Res, 2011
Overexpression of PRDX4 and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma
A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence.
Kamel-Reid et al., Toronto, Canada. In Bmc Cancer, 2010
This signature comprised the invasion-related genes MMP1, COL4A1, P4HA2, and THBS2.
Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium.
Fowler et al., Richmond, United States. In Am J Physiol Heart Circ Physiol, 2007
HIF-1 activation following infusion of siRNA to P4HA2 plays a key role in modulating I/R-associated cardiac inflammatory responses.
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.
Myllyharju et al., Oulu, Finland. In J Biol Chem, 2006
HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors
p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase.
Green et al., Worcester, United States. In Science, 2006
results show that p53 transcriptionally activates the alpha(II) collagen prolyl-4-hydroxylase [alpha(II)PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18
OCTNs: will the real IBD5 gene please stand up?
Silverberg, Toronto, Canada. In World J Gastroenterol, 2006
Several other genes, including IRF1 and P4HA2 may be equally as likely to contain the IBD5 causal variant as the OCTN genes.
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