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Prolyl 4-hydroxylase, alpha polypeptide I

P4HA1, PH alpha, prolyl 4-hydroxylase alpha-1 subunit, C-P4H alpha(I), collagen prolyl 4-hydroxylase-alpha(I)
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: P4HA2, CAN, HIF-1alpha, HAD, Alpha-1
Papers on P4HA1
Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma.
New
Abdollahi et al., Heidelberg, Germany. In Radiother Oncol, Jan 2016
Interestingly, the number of signature genes could be successfully reduced to the only common gene across all three signatures, i.e., P4HA1, encoding prolyl-4-hydroxylase, alpha polypeptide I. CONCLUSIONS: This is the first independent proof for the feasibility of hypoxia gene expression signatures as a prognostic tool in HNSCC patients.
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.
New
Roberts et al., Adelaide, Australia. In Eur J Cell Biol, Dec 2015
There was no difference in the expression level of any of the hypoxia responsive genes of interest, IGFBP3, P4HA1, P4HA2, ANGPTL4 and MMP1 between early and late first trimester placenta.
Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.
New
Myllyharju et al., Oulu, Finland. In J Biol Chem, Aug 2015
C-P4H-I is the major isoenzyme in most cells, and inactivation of its catalytic subunit (P4ha1(-/-)) leads to embryonic lethality in mouse, whereas P4ha1(+/-) mice have no abnormalities.
RGS6: a novel gene associated with congenital cataract, mental retardation, and microcephaly in a Tunisian family.
New
Chaabouni-Bouhamed et al., Tunisia. In Invest Ophthalmol Vis Sci, Feb 2015
Analysis of these regions by iSyTE allowed us to select 3 genes (RGS6, PCNX, and P4HA1) according to their expression in 3 critical stages of lens development.
GeneChip expression profiling reveals the alterations of energy metabolism related genes in osteocytes under large gradient high magnetic fields.
Qian et al., Xi'an, China. In Plos One, 2014
12 energy metabolism related genes (PFKL, AK4, ALDOC, COX7A1, STC1, ADM, CA9, CA12, P4HA1, APLN, GPR35 and GPR84) were further confirmed by real-time PCR.
The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression.
Varambally et al., United States. In Oncotarget, 2014
One of the isoforms of P4HA, Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), catalyzes the formation of 4-hydroxyproline that is essential for the proper three-dimensional folding of newly synthesized procollagen chains.
The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer.
Andrechek et al., East Lansing, United States. In Mol Cell Biol, 2014
Investigating E2F target genes that mediate metastasis, we found that E2F loss led to decreased levels of vascular endothelial growth factor (Vegfa), Bmp4, Cyr61, Nupr1, Plod 2, P4ha1, Adamts1, Lgals3, and Angpt2.
Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen.
Ludovico et al., Braga, Portugal. In Plos Negl Trop Dis, 2014
This revealed 20 changed spots corresponding to 18 proteins which were clustered mainly into cytoskeleton-related proteins (Dync1i2, Cfl1, Crmp2, Actg1, Stmn1) and collagen biosynthesis enzymes (Plod1, Plod3, P4ha1).
Analysis of gene expression profiles of soft tissue sarcoma using a combination of knowledge-based filtering with integration of multiple statistics.
Takahashi et al., Kasugai, Japan. In Plos One, 2013
We identified 25 genes, including hypoxia-related genes (e.g., MIF, SCD1, P4HA1, ENO1, and STAT1) and cell cycle- and DNA repair-related genes (e.g., TACC3, PRDX1, PRKDC, and H2AFY).
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
Semenza et al., Baltimore, United States. In J Biol Chem, 2013
HIF-1 activates expression of genes encoding collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD2) hydroxylases.
Identification of cold-responsive genes in a New Zealand alpine stick insect using RNA-Seq.
Buckley et al., Auckland, New Zealand. In Comp Biochem Physiol Part D Genomics Proteomics, 2013
Three candidate cold responsive genes from the RNA-Seq data were verified as significantly up-regulated, annotated as: prolyl 4-hydroxylase subunit alpha-1 (P4HA1), staphylococcal nuclease domain-containing protein 1 (snd1) and cuticular protein analogous to peritrophins 3-D2 (Cpap3-d2).
miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.
Li et al., Pittsburgh, United States. In J Hepatol, 2013
METHODS: The mRNA expression levels of miR-122, prolyl 4-hydroxylase subunit alpha-1 (P4HA1), and CCAAT/enhancer binding protein alpha (C/EBPα) were assessed by real-time PCR.
Helicase-like transcription factor (Hltf) regulates G2/M transition, Wt1/Gata4/Hif-1a cardiac transcription networks, and collagen biogenesis.
Chilton et al., Lubbock, United States. In Plos One, 2012
Hif-1a targets for prolyl (P4ha1, P4ha2) and lysyl (Plod2) collagen hydroxylation, PPIase enzymes (Ppid, Ppif, Ppil3) for collagen trimerization, and lysyl oxidase (Loxl2) for collagen-elastin crosslinking were downregulated.
The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma.
Crook et al., Ioánnina, Greece. In Br J Cancer, 2012
The C-P4Hs are tetrameric proteins comprising a variable α subunit, encoded by the P4HA1, P4HA2 and P4HA3 genes and a constant β subunit encoded by P4HB.
[Correlation of the methylation status of CpG islands in the promoter region of 10 genes with the 5-Fu chemosensitivity in 3 breast cancer cell lines].
Zhu et al., Shanghai, China. In Zhonghua Zhong Liu Za Zhi, 2010
The methylation profile of 10 genes (BAG1, C11ORF31, CBR1, CBR4, GJA1, FOXL2, IGFBP6, P4HA1, SRI and TYMS) in the 3 breast cancer cell lines was determined by methylation specific PCR.
Stringency of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase.
GeneRIF
Raines et al., Madison, United States. In Plos One, 2008
analysis of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.
GeneRIF
Myllyharju et al., Oulu, Finland. In J Biol Chem, 2006
HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors
Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia.
GeneRIF
Thiele et al., Berlin, Germany. In J Biol Chem, 2006
Results suggest that the alteration of translational efficiency by nucleolin, which occurs through a hypoxia inducible factor independent pathway, is an important step in collagen prolyl 4-hydroxylase-alpha(I) regulation under hypoxia.
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
GeneRIF
Pfander et al., Erlangen, Germany. In Am J Pathol, 2006
In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation.
Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors.
GeneRIF
Wang et al., Houston, United States. In J Biol Chem, 2006
positive (transforming growth factor beta1) and negative (cigarette smoking extract) regulators appear to influence the USF-E-box interaction and affect P4Halpha(I) expression
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