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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interferon regulatory factor 9

p48, HOD, Sti1
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, STAT1, STAT2, HAD
Papers on p48
Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing.
Liu et al., United States. In Mol Cell Proteomics, Feb 2016
Several novel ceramide-binding domains were discovered, including the EF-hand calcium-binding motif, the heat shock chaperonin-binding motif STI1, the SCP2 sterol-binding domain, and the tetratrico peptide repeat region (TPR) motif.
Riboflavin-ultraviolet light pathogen reduction treatment does not impact the immunogenicity of murine red blood cells.
Hendrickson et al., United States. In Transfusion, Jan 2016
STUDY DESIGN AND METHODS: Transgenic mice expressing a model (HOD) antigen, authentic human (hGPA or KEL) antigens, or natural fluorescence (uGFP) on their RBCs were utilized as blood donors.
Norovirus mechanisms of immune antagonism.
Karst et al., Gainesville, United States. In Curr Opin Virol, Jan 2016
In this review, we discuss these emerging strategies used by noroviruses to subvert the immune response, including the actions of two nonstructural proteins (p48 and p22) to impair cellular protein trafficking and secretory pathways; the ability of the VF1 protein to inhibit cytokine induction; and the ability of the minor structural protein VP2 to regulate antigen presentation.
Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
Prado et al., London, Canada. In Dis Model Mech, Dec 2015
Stress-inducible phosphoprotein I (STIP1, STI1 or HOP) is a co-chaperone intermediating Hsp70/Hsp90 exchange of client proteins, but it can also be secreted to trigger prion protein-mediated neuronal signaling.
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.
Wilkie et al., Dallas, United States. In Dis Model Mech, Nov 2015
Candidate drugs identified in organ culture or cell-based screens must be validated in preclinical models such as KIC (p48(Cre);LSL-Kras(G12D);Cdkn2a(f/f)) mice, a genetically engineered model of PDA in which large aggressive tumors develop by 4 weeks of age.
The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease.
Crispino et al., Chicago, United States. In Biochim Biophys Acta, Aug 2015
Whereas the diverse functions of the large (CAF-1-p150, CHAF1a) and small (RbAp48, p48) subunits of the CAF-1 complex have been well-characterized in many tissues and extend beyond histone chaperone activity, the contributions of the medium subunit (CAF-1-p60, CHAF1b) are much less well understood.
Targeting prion protein interactions in cancer.
Martins et al., Camargo, Spain. In Prion, 2014
Recently, our group successfully used that approach to interfere with the interaction between PrP(C) and HSP-90/70 organizing protein (HOP, also known as stress-inducible protein 1 - STI1) to control the growth of human glioblastoma in animal models.
Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins.
Blatch et al., Melbourne, Australia. In Subcell Biochem, 2014
The Hsp70/Hsp90 organising protein (Hop), also known as stress-inducible protein 1 (STI1), has received considerable attention for diverse cellular functions in both healthy and diseased states.
Visualization of in vivo degradation of aliphatic polyesters by a fluorescent dendritic star macromolecule.
Cai et al., Beijing, China. In Biomed Mater, 2014
In this study, a fluorescent perylenediimide-cored (PDI-cored) dendritic star macromolecule bearing multiple amines (d-p48) was incorporated into biodegradable polyester nanofibrous scaffolds by eletrospinning as an indicator.
Hypertrophic olivary degeneration on magnetic resonance imaging in mitochondrial syndromes associated with POLG and SURF1 mutations.
Omer et al., London, United Kingdom. In J Neurol, 2013
Hypertrophic olivary degeneration (HOD) is associated with lesions within the dento-rubro-olivary pathway or Guillain-Mollaret triangle and may be associated clinically with palatal tremor.
Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus.
Campbell et al., Sydney, Australia. In J Virol, 2012
STAT1, not STAT2 or IRF9, prevent the emergence of a lethal antiviral CD4(+) T-cell response after lymphocytic choriomeningitis virus infection.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein.
Losordo et al., Chicago, United States. In Lab Invest, 2012
Estradiol improves the recovery of injured nerves by downregulating the Shh inhibitor hedgehog-interacting protein and increasing Shh-induced angiogenesis.
Regulation of vascular endothelial cell polarization and migration by Hsp70/Hsp90-organizing protein.
Liu et al., Tianjin, China. In Plos One, 2011
HOP as a novel regulator of angiogenesis that functions through promoting vascular endothelial cell polarization and migration
Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell.
Guo et al., Shanghai, China. In Pancreatology, 2010
Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cells.(
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Schmid et al., M√ľnchen, Germany. In Cancer Cell, 2007
In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras(G12D) by crossing Elastase-Tgfa mice with p48(+/Cre);Kras(+/LSL-G12D) mice.
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.
Casanova et al., Paris, France. In Nat Genet, 2003
STAT1 interacts with STAT2 and p48/IRF-9 to form the transcription factor IFN-stimulated gene factor 3 (ISGF3).
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.
Wright et al., Nashville, United States. In Nat Genet, 2002
We used recombination-based lineage tracing in vivo to show that Ptf1a (also known as PTF1-p48) is expressed at these early stages in the progenitors of pancreatic ducts, exocrine and endocrine cells, rather than being an exocrine-specific gene as previously described.
Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein.
Kenney et al., Chapel Hill, United States. In Immunity, 2001
BZLF1 decreases the ability of IFN-gamma to activate a variety of important downstream target genes, such as IRF-1, p48, and CIITA, and prevents IFN-gamma-induced class II MHC surface expression.
A central role for P48/45 in malaria parasite male gamete fertility.
Eling et al., Leiden, Netherlands. In Cell, 2001
p48/45- parasites had a reduced capacity to produce oocysts in mosquitoes due to greatly reduced zygote formation.
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