Norovirus mechanisms of immune antagonism.
Gainesville, United States. In Curr Opin Virol, Jan 2016
In this review, we discuss these emerging strategies used by noroviruses to subvert the immune response, including the actions of two nonstructural proteins (p48 and p22) to impair cellular protein trafficking and secretory pathways; the ability of the VF1 protein to inhibit cytokine induction; and the ability of the minor structural protein VP2 to regulate antigen presentation.
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.
Dallas, United States. In Dis Model Mech, Nov 2015
Candidate drugs identified in organ culture or cell-based screens must be validated in preclinical models such as KIC (p48(Cre);LSL-Kras(G12D);Cdkn2a(f/f)) mice, a genetically engineered model of PDA in which large aggressive tumors develop by 4 weeks of age.
Targeting prion protein interactions in cancer.
Camargo, Spain. In Prion, 2014
Recently, our group successfully used that approach to interfere with the interaction between PrP(C) and HSP-90/70 organizing protein (HOP, also known as stress-inducible protein 1 - STI1) to control the growth of human glioblastoma in animal models.