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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neutrophil cytosolic factor 1

p47phox, NCF1
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ros, p67phox, V1a, ACID, CAN
Papers on p47phox
NOX2 Activation of NKT Cells is Blocked by Adenosine A2A Receptor to Inhibit Lung Reperfusion Injury.
New
Laubach et al., Charlottesville, United States. In Am J Respir Crit Care Med, Feb 2016
MEASUREMENTS AND MAIN RESULTS: Adoptive transfer of iNKT cells from p47phox-/- or NOX2-/- mice to Jα18-/- mice (iNKT cell-deficient) significantly attenuated lung ischemia-reperfusion injury and IL-17 production.
Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells.
New
Katiyar et al., Birmingham, United States. In Oncotarget, Feb 2016
Further, we examined the effect of honokiol on the levels of core proteins (p22phox and p47phox) of the NADPH oxidase complex.
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.
Review
New
Wing et al., Stockholm, Sweden. In Immunol Rev, Jan 2016
The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders.
Chronic Granulomatous Disease: clinical, molecular and therapeutic aspects.
Review
New
Finocchi et al., Roma, Italy. In Pediatr Allergy Immunol, Jan 2016
CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA, NCF1, NCF2 or NCF4 genes encoding p22(phox) , p47(phox) , p67(phox) and p40(phox) , respectively.
Genetic disorders coupled to ROS deficiency.
Review
New
Knaus et al., Dublin, Ireland. In Redox Biol, Dec 2015
In particular, deficiency in phagocyte Nox2 oxidase function due to genetic variants (CYBB, CYBA, NCF1, NCF2, NCF4) has been recognized as a direct cause of chronic granulomatous disease (CGD), an inherited immune disorder.
Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
New
Kim et al., South Korea. In J Neuroinflammation, Dec 2015
METHODS: We examined changes in mitogen-activated protein kinases (MAPKs), mitochondrial function [i.e., mitochondrial membrane potential, intramitochondrial Ca(2+) accumulation, mitochondrial oxidative burdens, mitochondrial superoxide dismutase expression, and mitochondrial translocation of the cleaved form of protein kinase C delta type (cleaved PKCδ)], microglial activity, and pro-apoptotic changes [i.e., cytosolic cytochrome c release, cleaved caspase 3, and terminal deoxynucleotidyl transferase dUDP nick-end labeling (TUNEL) positive populations] after a neurotoxic dose of MA in the striatum of mice to achieve a better understanding of the effects of apocynin, a non-specific PHOX inhibitor, or genetic inhibition of p47phox (by using p47phox knockout mice or p47phox antisense oligonucleotide) against MA-induced dopaminergic neurotoxicity.
Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization.
New
Kim et al., Seoul, South Korea. In Anat Cell Biol, Dec 2015
To block the CaMKII oxidization, gene of p47phox, a cytosolic subunit of NADPH oxidase, was deleted using Cas9 KO plasmid.
[Effect of Serum Containing Sesamin on Angiotensin II-Induced Apoptosis in Rat Cardiomyocytes].
New
Yang et al., In Zhong Yao Cai, May 2015
Protein expression of BCL-2, BAX, Caspase-3, p47phox and superoxide dismutase (SOD) was determined by Western blot analysis.
Mechanisms of renal sympathetic activation in renovascular hypertension.
Review
New
Bergamaschi et al., São Paulo, Brazil. In Exp Physiol, May 2015
In addition, mRNA from NADPH oxidase subunits (p47phox and gp91phox) was greater in the RVLM and PVN of 2K-1C rats than in a sham-operated group.
Rac-1 as a new therapeutic target in cerebro- and cardio-vascular diseases.
Review
Vecchione et al., Israel. In Curr Drug Targets, 2013
Vascular NAD(P)H oxidase contains the membrane-bound subunits Nox1, Nox2 (gp91phox), Nox4 and p22phox, the catalytic site of the oxidase, and the cytosolic components p47phox and p67phox.
The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
Impact
Coste et al., Toulouse, France. In Immunity, 2013
Dectin-1 and MR were crucial for the microbicidal response as indicated by the fact that they activated Syk-p47phox and arachidonic acid (AA)-NADPH oxidase signaling pathways, respectively, needed for ROS production and also triggered Syk-coupled signaling for caspase-1-induced IL-1β secretion.
NADPH oxidase mediates depressive behavior induced by chronic stress in mice.
GeneRIF
Han et al., Seoul, South Korea. In J Neurosci, 2012
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH oxidasesubunit (47 kD) and the resultant metabolic oxidative stres.
Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways.
GeneRIF
Tostes et al., São Paulo, Brazil. In Hypertension, 2012
Study shows that testosterone induces vascular smooth muscle cells (VSMCs) migration via NADPH oxidase (Nox1 and Nox4 mRNA levels and p47phox)-derived reactive oxygen species (ROS) and c-Src-dependent pathways.
Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.
GeneRIF
Shimada et al., United States. In J Biol Chem, 2012
The low affinity and selectivity of the atypical phosphoinositide-binding site on the p47(phox) PX domain suggest that different types of phosphoinositides sequentially bind to the p47(phox) PX domain
[Analysis of p22-phox and p47-phox subcellular localization and distribution in neutrophils from human immunodeficiency virus (HIV) infected patients].
GeneRIF
Berrueta et al., Mérida, Venezuela. In Rev Invest Clin, 2012
A diffuse cytosolic distribution of p47-phox was observed in neutrophils from HIV-infected patients.
PP2A-dependent control of transcriptionally active FOXO3a in CD8(+) central memory lymphocyte survival requires p47(phox).
GeneRIF
Jackson et al., Bethesda, United States. In Cell Death Dis, 2011
A critical role for p47(phox) in a dynamic interplay between PP2A and FOXO3a that regulates pro-apoptotic Bim transcription in CD8(+) memory lymphocytes during infection.
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.
Review
Impact
Sobey et al., Australia. In Nat Rev Drug Discov, 2011
In addition, we highlight the crucial role of the NADPH oxidase regulatory subunit, p47phox, in the activity of vascular NOX1 and NOX2 oxidases, and suggest how a better understanding of its specific molecular interactions may enable the development of novel isoform-selective drugs to prevent or treat cardiovascular diseases.
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Impact
Penninger et al., Vienna, Austria. In Cell, 2008
Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI.
Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia.
Impact
Karpatkin et al., New York City, United States. In Cell, 2001
The mechanism of complement-independent platelet lysis is shown to be caused by the antibody-induced generation of H202, as indicated by in vitro experiments with inhibitors of reactive oxygen species, and in vivo studies carried out with p47phox-deficient mice.
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Impact
Yaffe et al., Cambridge, United States. In Nat Cell Biol, 2001
We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3-phosphate (PtdIns(3)P), respectively.
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