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Cytochrome P450, family 11, subfamily A, polypeptide 1

P450scc, Cholesterol Side-Chain Cleavage Enzyme, CYP11A1, CYP11A
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, P450c17, STEP, ACID
Papers on P450scc
Metabolism of Oral Turinabol by Human Steroid Hormone-Synthesizing Cytochrome P450 Enzymes.
New
Bernhardt et al., Saarbrücken, Germany. In Drug Metab Dispos, Feb 2016
The human mitochondrial cytochrome P450 enzymes CYP11A1, CYP11B1, and CYP11B2 are involved in the biosynthesis of steroid hormones.
Luteal P4 synthesis in early pregnant gilts after induction of estrus with PMSG/hCG.
New
Morawska-Pucinska et al., Olsztyn, Poland. In Anim Reprod Sci, Feb 2016
Corpora lutea (CLs) were collected on days 10, 12 and 15 of pregnancy and analyzed for (1) the mRNA and protein expression of steroidogenic acute regulatory protein (StAR), cytochrome P450 family 11 subfamily A polypeptide 1 (CYP11A1), and 3β-hydroxysteroid dehydrogenase (3βHSD); (2) the tissue concentration of P4; and (3) the mRNA expression of luteinizing hormone receptor (LHR) and estrogen receptors (ESR1 and ESR2).
A Family-Based Association Study of CYP11A1 and CYP11B1 Gene Polymorphisms With Autism in Chinese Trios.
New
Zou et al., Guangzhou, China. In J Child Neurol, Jan 2016
Our previous studies have indicated lower progesterone levels in the children with autism spectrum disorder, suggesting involvement of the cytochrome P-450scc gene (CYP11A1) and cytochrome P-45011beta gene (CYP11B1) as candidate genes in autism spectrum disorder.
Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis?
New
Stárka et al., Praha, Czech Republic. In J Steroid Biochem Mol Biol, Jan 2016
The steroid levels (47 steroids and steroid polar conjugates) and their ratios in AD female patients indicated increased CYP11A1 activity, weakened activity of the CYP17A1C17,20 lyase metabolic step and attenuated sulfotransferase SULT2A1 activity at higher activity of the CYP17A1 17-hydroxylase step.
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
New
Gelfand et al., Denver, United States. In Nat Commun, Dec 2015
1,25D3 alters vitamin D receptor (VDR) recruitment to the Cyp11a1 promoter in vitro and in vivo in the presence of IL-4.
Novel activities of CYP11A1 and their potential physiological significance.
Review
New
Tuckey et al., Memphis, United States. In J Steroid Biochem Mol Biol, Jul 2015
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where cholesterol is converted to pregnenolone.
Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR).
Review
New
Orly et al., Jerusalem, Israel. In Mol Cell Endocrinol, Jul 2015
High output of steroid hormone synthesis in steroidogenic cells of the adrenal cortex and the gonads requires the expression of the steroidogenic acute regulatory protein (StAR) that facilitates cholesterol mobilization to the mitochondrial inner membrane where the CYP11A1/P450scc enzyme complex converts the sterol to the first steroid.
Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.
Review
New
Tuckey et al., Memphis, United States. In J Steroid Biochem Mol Biol, Apr 2015
CYP11A1 hydroxylates the side chain of vitamin D3 (D3) in a sequential fashion [D3→20S(OH)D3→20,23(OH)2D3→17,20,23(OH)3D3], in an alternative to the classical pathway of activation [D3→25(OH)D3→1,25(OH)2D3]. The products/intermediates of the pathway can be further modified by the action of CYP27B1.
CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds.
Review
New
Mason et al., Sydney, Australia. In J Steroid Biochem Mol Biol, Apr 2015
A possible explanation is that an alternative pathway, which does not involve 1α-hydroxylation, may produce photoprotective compounds from vitamin D. The cholesterol side chain cleavage enzyme CYP11A1 is expressed in skin and produces 20-hydroxyvitamin D3 (20OHD) as a major product of vitamin D3.
Congenital lipoid adrenal hyperplasia.
Review
Kim, Kwangju, South Korea. In Ann Pediatr Endocrinol Metab, 2014
The cholesterol side-chain cleavage enzyme, P450scc (CYP11A1), plays an essential role converting cholesterol to pregnenolone.
Molecular cloning and expression patterns of the cholesterol side chain cleavage enzyme (CYP11A1) gene during the reproductive cycle in goose (Anas cygnoides).
Chen et al., Yangzhou, China. In J Anim Sci Biotechnol, 2014
BACKGROUND: CYP11A1, a gene belonging to the family 11 of cytochrome P450, encodes a crucial steroidogenic enzyme that catalyzes the initial step in the production of all classes of steroids.
Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women.
GeneRIF
Wang et al., Nanjing, China. In Mol Biol Rep, 2012
SNP rs4077582 in CYP11A1 is strongly associated with susceptibility to PCOS and may alter the testosterone levels by the regulation of LH in different genotypes. No association was observed in rs11632698.
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.
GeneRIF
Sewer et al., San Diego, United States. In Endocrinology, 2012
NAD(+)-dependent SIRT deacetylase has a role in regulating the expression of mitochondrial steroidogenic P450
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
GeneRIF
Pikuleva et al., Cleveland, United States. In Arch Biochem Biophys, 2012
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Review
Impact
Auchus et al., San Francisco, United States. In Endocr Rev, 2011
The first and rate-limiting step in steroidogenesis is the conversion of cholesterol to pregnenolone by a single enzyme, P450scc (CYP11A1), but this enzymatically complex step is subject to multiple regulatory mechanisms, yielding finely tuned quantitative regulation.
Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.
Review
Impact
Sharpe et al., Edinburgh, United Kingdom. In Endocr Rev, 2009
This comparison identifies steroidogenic targets that are either vulnerable (mitochondrial cholesterol transport, CYP11A, CYP17) or not (cholesterol uptake) to chemical interference.
Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement.
Impact
Chung et al., Taipei, Taiwan. In Nature, 2006
Here we report that pregnenolone, which is produced from cholesterol by the steroidogenic enzyme Cyp11a1 (cholesterol side-chain cleavage enzyme, P450scc), functions in promoting cell migration during epiboly.
Total biosynthesis of hydrocortisone from a simple carbon source in yeast.
Impact
Dumas et al., Gif-sur-Yvette, France. In Nat Biotechnol, 2003
Biosynthesis involves eight mammalian proteins (mature forms of CYP11A1, adrenodoxin (ADX), and adrenodoxin reductase (ADR); mitochondrial forms of ADX and CYP11B1; 3beta-HSD, CYP17A1, and CYP21A1).
Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells.
Review
GeneRIF
Hammond et al., Ann Arbor, United States. In J Steroid Biochem Mol Biol, 1992
Data suggest that the 5' flanking region of CYP11A gene contains sequences between 2.5 and 5 kb that are necessary for expression of mouse CYP11A in Leydig cells but not in adrenal cells. [REVIEW]
Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes.
Review
GeneRIF
Simpson et al., Dallas, United States. In J Steroid Biochem Mol Biol, 1992
Data suggest that the upstream region of gene encoding CYP11A contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex.
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