Luteal P4 synthesis in early pregnant gilts after induction of estrus with PMSG/hCG.
Olsztyn, Poland. In Anim Reprod Sci, Feb 2016
Corpora lutea (CLs) were collected on days 10, 12 and 15 of pregnancy and analyzed for (1) the mRNA and protein expression of steroidogenic acute regulatory protein (StAR), cytochrome P450 family 11 subfamily A polypeptide 1 (CYP11A1), and 3β-hydroxysteroid dehydrogenase (3βHSD); (2) the tissue concentration of P4; and (3) the mRNA expression of luteinizing hormone receptor (LHR) and estrogen receptors (ESR1 and ESR2).
CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds.
Sydney, Australia. In J Steroid Biochem Mol Biol, Apr 2015
A possible explanation is that an alternative pathway, which does not involve 1α-hydroxylation, may produce photoprotective compounds from vitamin D. The cholesterol side chain cleavage enzyme CYP11A1 is expressed in skin and produces 20-hydroxyvitamin D3 (20OHD) as a major product of vitamin D3.
Congenital lipoid adrenal hyperplasia.
Kwangju, South Korea. In Ann Pediatr Endocrinol Metab, 2014
The cholesterol side-chain cleavage enzyme, P450scc (CYP11A1), plays an essential role converting cholesterol to pregnenolone.