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Cytochrome P450, family 17, subfamily A, polypeptide 1

P450c17, Steroid 17-alpha-Hydroxylase, CYP17A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: P450scc, HAD, CAN, AGE, Progesterone Reductase
Papers using P450c17 antibodies
Regulation of Leydig cell steroidogenic function during aging.
Supplier
Kim Jong-Min et al., In Environmental Health Perspectives, 1999
... Anti-StAR antibody was purchased from Abcam (Cambridge, UK), and anti–3β-HSD and anti-CYP17A1 antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
Papers on P450c17
High-throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells.
New
Martin et al., Durham, United States. In Toxicol Sci, Feb 2016
Clustering of the concentration-dependent chemical-mediated steroid hormone effects grouped chemical samples into five distinct profiles generally representing putative mechanisms of action, including CYP17A1 and HSD3B inhibition.
Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice.
New
Gao et al., In Reprod Fertil Dev, Feb 2016
In in vitro-cultured ovaries, Rheb and GTP (is 100 ng mL-1 Rheb and 500 ng mL-1 GTP for 48 h) significantly increased follicle diameter, the percentage of primary and secondary follicles and the umber of thecal cells, and upregulated expression of mTOR, phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), eukaryotic initiation factor (eIF) 4F and cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1).
Involvement of hypoxia-inducible factor-1α in the oxidative stress induced by advanced glycation end products in murine Leydig cells.
New
Sun et al., Chongqing, China. In Toxicol In Vitro, Jan 2016
The expression of caspase-3, Heme oxygenase (HO)-1, steroidogenic acute regulatory protein (StAR) and cytochrome P450 17α polypeptide 1 (CYP17A1) was examined by Western blotting.
Skeletal adverse effects with aromatase inhibitors in early breast cancer: evidence to date and clinical guidance.
Review
New
Tusquets et al., Barcelona, Spain. In Ther Adv Med Oncol, Sep 2015
We also demonstrate that AIrA is genetically determined: single nucleotide polymorphisms located in genes encoding key factors for the metabolism of estrogens and vitamin D (CYP17A1, VDR, and CYP27B1) are associated with self-reported arthralgia during AI therapy.
Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer.
New
Impact
Sharifi et al., Cleveland, United States. In Nature, Aug 2015
Abiraterone, a steroidal 17α-hydroxylase/17,20-lyase (CYP17A1) inhibitor, blocks this synthetic process and prolongs survival.
The development of abiraterone acetate for castration-resistant prostate cancer.
Review
New
Attard et al., London, United Kingdom. In Urol Oncol, Jun 2015
Abiraterone acetate is a novel CYP17A1 inhibitor demonstrated to prolong survival in castration-resistant prostate cancer (CRPC).
Regioselective hydroxylation of steroid hormones by human cytochromes P450.
Review
New
Yamazaki et al., Okayama, Japan. In Drug Metab Rev, May 2015
CYP17A1, CYP19A1 and CYP27A1 catalyzed steroid synthesis, including hydroxylation at 17α, 19 and 27 positions, respectively.
Metastatic castration-resistant prostate cancer: targeting the mechanisms of resistance to abiraterone acetate and enzalutamide.
Review
Massari et al., Verona, Italy. In Expert Rev Anticancer Ther, 2014
Although the impressive clinical activity of new hormonal agents, such as the second-generation AR antagonist enzalutamide (formerly MDV3100) and the selective inhibitor of cytochrome P450 17A1 (CYP17A1) abiraterone acetate (AA), in patients with metastatic castration-resistant prostate cancer (mCRPC), innate or acquired resistance invariably arises.
Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1.
Review
Wright et al., Lahore, Pakistan. In Adv Exp Med Biol, 2014
However, when the substrate projects a carbonyl functionality, of the type b, at the active site as is the case for reactions catalyzed by CYP17A1, CYP19A1 and CYP51A1, the peroxy anion (FeIII-O-O-) is trapped, yielding a tetrahedral intermediate (c) that fragments to an acyl-carbon cleavage product (d plus an acid).
Genetic polymorphisms in the androgen metabolism pathway and risk of prostate cancer in low incidence Malaysian ethnic groups.
Razack et al., Kuala Lumpur, Malaysia. In Int J Clin Exp Med, 2014
We genotyped 172 Malaysian subjects for cytochrome P450 family 17 (CYP17A1), steroid-5-alpha-reductase, polypeptide 1 and 2 (SRD5A1 and SRD5A2), and insulin-like growth factor 1 (IGF-1) genes of the androgen metabolism pathway and assessed the testosterone, dihydrotestosterone and IGF-1 levels.
Clinical characteristics and mutation analysis of two Chinese children with 17a-hydroxylase/17,20-lyase deficiency.
Gu et al., Nanjing, China. In Int J Clin Exp Med, 2014
17a-hydroxylase/17,20-lyase deficiency, a rare form of congenital adrenal hyperplasia, is caused by mutations in the cytochrome P450c17 gene (CYP17A1), and characterized by hypertension, hypokalemia, female sexual infantilism or male pseudohermaphroditism.
Effect of CYP17 and PSA gene polymorphisms on prostate cancer risk and circulating PSA levels in the Slovak population.
GeneRIF
Kliment et al., Martin, Slovakia. In Mol Biol Rep, 2012
Our study did not provide support for the hypothesized relationship between CYP17 and PSA gene polymorphisms and prostate cancer in the Slovak male population.
A false single nucleotide polymorphism generated by gene duplication compromises meat traceability.
GeneRIF
Rodellar et al., Zaragoza, Spain. In Meat Sci, 2012
By alignment analysis and sequencing, we detected that the g.329C>T SNP is a false positive polymorphism, which allows us to explain the inflated heterozygotic value.
MspA1 polymorphism of the CYP17 gene in breast cysts.
GeneRIF
Nazário et al., São Paulo, Brazil. In Gynecol Endocrinol, 2012
A trend of the MspAI polymorphism of the gene CYP17 to act as a protective factor against the development of breast cysts.
Genetic polymorphism CYP17 rs2486758 and metabolic risk factors predict daily salivary 17β-estradiol concentration in healthy premenopausal Norwegian women. The EBBA-I study.
GeneRIF
Furberg et al., Tromsø, Norway. In J Clin Endocrinol Metab, 2012
The CYP17 rs2486758 minor allele may predispose to higher 17beta-estradiol levels, particularly in premenopausal women with a high clustered metabolic score.
Expression of P450c17 in the human fetal nervous system.
GeneRIF
Mellon et al., San Francisco, United States. In Endocrinology, 2012
p450c17 was detected in dorsal root ganglia and spinal cord.
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.
Impact
GeneRIF
Scott et al., Lawrence, United States. In Nature, 2012
X-ray crystal structures of CYP17A1, which were obtained in the presence of either abiraterone or TOK-001
Genome-wide association study identifies eight loci associated with blood pressure.
Impact
Munroe et al., Boston, United States. In Nat Genet, 2009
We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes.
Genome-wide association study of blood pressure and hypertension.
Impact
van Duijn et al., Framingham, United States. In Nat Genet, 2009
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1).
Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study.
Impact
Shackleton et al., Birmingham, United Kingdom. In Lancet, 2004
BACKGROUND: Congenital adrenal hyperplasia with apparent combined P450C17 and P450C21 deficiency is associated with accumulation of steroid metabolites, indicating impaired activity of 17alpha-hydroxylase and 21-hydroxylase.
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