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Neutrophil cytosolic factor 4, 40kDa

p40phox, NCF, NCF4
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p47phox, p67phox, p63, CAN, Akt
Papers on p40phox
Equol Effectively Inhibits Toxic Activity of Human Neutrophils without Influencing Their Viability.
Jančinová et al., Bratislava, Slovakia. In Pharmacology, Feb 2016
The phosphorylation of p40phox (a component of NADPH oxidase, responsible for the assembly of functional oxidase in intracellular membranes) was reduced in the presence of equol.
Lavandula angustifolia Mill. Essential Oil Exerts Antibacterial and Anti-Inflammatory Effect in Macrophage Mediated Immune Response to Staphylococcus aureus.
Cappelli et al., Roma, Italy. In Immunol Invest, Jan 2016
Our data showed that this stimulation is coupled with expression of genes involved in reactive oxygen species production (i.e., CYBB and NCF4).
Chronic Granulomatous Disease: clinical, molecular and therapeutic aspects.
Finocchi et al., Roma, Italy. In Pediatr Allergy Immunol, Jan 2016
CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA, NCF1, NCF2 or NCF4 genes encoding p22(phox) , p47(phox) , p67(phox) and p40(phox) , respectively.
Exploring the (H2C═PH2)(+):N-Base Potential Surfaces: Complexes Stabilized by Pnicogen, Hydrogen, and Tetrel Bonds.
Elguero et al., Youngstown, United States. In J Phys Chem A, Jan 2016
Ab initio MP2/aug'-cc-pVTZ calculations have been carried out to determine the structures, binding energies, and bonding properties of complexes involving the cation (H2C═PH2)(+) and a set of sp-hybridized nitrogen bases including NCCH3, NP, NCCl, NCH, NCF, NCCN, and N2.
Genetic disorders coupled to ROS deficiency.
Knaus et al., Dublin, Ireland. In Redox Biol, Dec 2015
In particular, deficiency in phagocyte Nox2 oxidase function due to genetic variants (CYBB, CYBA, NCF1, NCF2, NCF4) has been recognized as a direct cause of chronic granulomatous disease (CGD), an inherited immune disorder.
Dairy proteins and soy proteins in infant foods nitrogen-to-protein conversion factors.
Lorient et al., Rennes, France. In Dairy Sci Technol, Dec 2015
UNASSIGNED: Protein content of any source is classically determined through the analysis of its nitrogen content done for more 100 years by the Kjeldahl method, and the obtained result is multiplied by a number named nitrogen conversion factor (NCF).
Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle.
Hayes et al., Australia. In Mamm Genome, Dec 2015
There was statistical support for imputed sequence variants in or close to BTRC, MGST1, SLC37A1, STAT5A, STAT5B, PAEP, VDR, CSF2RB, MUC1, NCF4, and GHDC associated with milk production, and EPGN for calving interval.
Association between NCF4 rs4821544T/C polymorphism and inflammatory bowel disease risk in Caucasian: a meta-analysis.
Ye et al., Wuhan, China. In Inflamm Res, Oct 2015
OBJECTIVE: Published studies on the association between NCF4 rs4821544T/C polymorphism and inflammatory bowel disease (IBD) risk in Caucasian have yielded conflicting results.
Role of an SNP in Alternative Splicing of Bovine NCF4 and Mastitis Susceptibility.
Huang et al., Jinan, China. In Plos One, 2014
Neutrophil cytosolic factor 4 (NCF4) is component of the nicotinamide dinucleotide phosphate oxidase complex, a key factor in biochemical pathways and innate immune responses.
Chronic Granulomatous Disease
Holland et al., Seattle, United States. In Unknown Journal, 2012
CGD is caused by mutation of one of five genes that encode the subunits of phagocyte NADPH oxidase: biallelic mutations in CYBA, NCF1, NCF2, and NCF4 cause autosomal recessive CGD (AR-CGD); mutation of CYBB causes X-linked CGD.
Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohort.
Gearry et al., Christchurch, New Zealand. In Am J Gastroenterol, 2012
Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.
NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults.
Levy et al., Montréal, Canada. In Inflamm Bowel Dis, 2012
Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.
Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.
Saito et al., Kōbe, Japan. In J Biol Chem, 2011
cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis
Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase.
Marshall et al., Toronto, Canada. In J Immunol, 2011
Results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane.
Granulomas in Crohn's disease: are newly discovered genetic variants involved?
Eliakim et al., Israel. In J Crohns Colitis, 2010
no association between SNP rs4821544 and the presence of granulomas in Crohn's disease
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
Brant et al., Montréal, Canada. In Nat Genet, 2007
We also report strong associations with independent replication to variation in the genomic regions encoding PHOX2B, NCF4 and a predicted gene on 16q24.1 (FAM92B).
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Yaffe et al., Cambridge, United States. In Nat Cell Biol, 2001
We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3-phosphate (PtdIns(3)P), respectively.
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
Malech et al., Bethesda, United States. In Science, 1989
A 47-kilodalton neutrophil cytosol factor (NCF-47k), required for activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase superoxide (O2-.)
Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta.
Marks et al., Ann Arbor, United States. In Science, 1989
Human endothelial cells produced a neutrophil chemotactic factor (NCF) upon stimulation with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), or lipopolysaccharide (LPS).
Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.
Malech et al., Bethesda, United States. In Science, 1989
Anion exchange chromatography separated from normal neutrophil cytosol a 47-kilodalton neutrophil cytosol factor, NCF-1, that restored activity to defective neutrophil cytosol from most patients with autosomally inherited CGD in a cell-free O2.--generating system.
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