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Mitogen-activated protein kinase 13

p38delta, Mitogen-Activated Protein Kinase 13, SAPK4, MAPK13
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, Mitogen-Activated Protein Kinase 3, MAPK, p38beta, JNK
Papers on p38delta
1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells.
New
Kumar et al., Rochester, United States. In J Biol Chem, Feb 2016
MYC, MAPK13, and EPAS1 mRNAs, which encode proteins that regulate mitochondrial biogenesis, were increased following 1α,25(OH)2D3 treatment.
Gene structure, molecular characterization and transcriptional expression of two p38 isoforms (MAPK11 and MAPK14) from rock bream (Oplegnathus fasciatus).
New
Lee et al., Cheju, South Korea. In Fish Shellfish Immunol, Nov 2015
The p38 subfamily that includes four members namely p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12) and p38δ (MAPK13), regulates the activation of several transcription factors.
Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps.
New
Yamaguchi et al., Kumamoto, Japan. In Blood Cells Mol Dis, Aug 2015
Interestingly, a combined p38gamma and p38delta inhibitor (BIRB796) significantly decreased IFN-gamma production.
miR-155 Regulates Glioma Cells Invasion and Chemosensitivity by p38 Isforms In Vitro.
New
Fang et al., Changsha, China. In J Cell Biochem, Jul 2015
Knockdown of miR-155 sensitizes glioma cells to the chemotherapy of temozolomide (TMZ) by targeting the p38 isoforms mitogen-activated protein kinase 13 [MAPK13, also known as p38 MAPKδ or stress-activated protein kinase 4 (SAPK4)] and MAPK14 (also known as p38 MAPKα).
Mechanism of interleukin-13 production by granulocyte-macrophage colony-stimulating factor-dependent macrophages via protease-activated receptor-2.
New
Yamaguchi et al., Kumamoto, Japan. In Blood Cells Mol Dis, Jun 2015
Neither SB203580 (a p38alpha/p38beta inhibitor) nor BIRB796 (a p38gamma/p38delta inhibitor) affected IL-13 production, while TMB-8 (a calcium chelator) diminished IL-13 production.
miRNAs dysregulated in association with Gleason grade regulate extracellular matrix, cytoskeleton and androgen receptor pathways.
New
Yousef et al., Toronto, Canada. In J Pathol, Jun 2015
Transfection with miR-29c, miR-34a and miR-141 repressed genes involved in ECM-mediated pathways, such as SRC, PRKCA, COL1A1, ITGB1 and MAPK13, and decreased cell proliferation and migration.
The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.
New
Brett et al., Saint Louis, United States. In Acta Crystallogr D Biol Crystallogr, Apr 2015
Recent studies indicate that family members such as MAPK13 (p38δ) display a selective cellular and tissue expression and are therefore involved in specific diseases.
Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression.
Barry et al., Cork, Ireland. In Cancers (basel), 2014
We did not identify any mutations in the MAPK13 sequence in OESCC cell lines which lack p38δ MAPK expression.
Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.
GeneRIF
Alkan et al., Davis, United States. In J Biol Chem, 2012
SEPW1 silencing increases MKK4, which activates p38gamma, p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest.
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.
GeneRIF
Cuenda et al., Madrid, Spain. In Proc Natl Acad Sci U S A, 2012
p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase Cδ- and p38δ-dependent signaling and keratinocyte differentiation.
GeneRIF
Eckert et al., Baltimore, United States. In J Biol Chem, 2012
PRMT5 inhibits the PKCdelta- or 12-O-tetradecanoylphorbol-13-acetate-dependent increase in human involucrin expression, and PRMT5 dimethylates proteins in the p38delta complex.
Evidence of p38γ and p38δ involvement in cell transformation processes.
GeneRIF
Cuenda et al., Madrid, Spain. In Carcinogenesis, 2011
results indicate that p38gamma and p38delta have a role in the suppression of tumor development
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.
GeneRIF
Iversen et al., Århus, Denmark. In Acta Derm Venereol, 2011
Demonstrate roles of the p38alpha/beta/delta isoforms in the regulation of 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation.
p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis.
Review
GeneRIF
Efimova, Saint Louis, United States. In Cell Cycle, 2010
Function of p38delta in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development, is discussed.
p38delta and PKD1: kinase switches for insulin secretion.
Impact
Nebreda et al., Madrid, Spain. In Cell, 2009
In this issue, Sumara et al. (2009) report key roles for the protein kinases p38delta and PKD1 in the regulation of insulin secretion as well as in the survival of pancreatic beta cells.
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Impact
GeneRIF
Ricci et al., Zürich, Switzerland. In Cell, 2009
Deletion of p38delta results in activation of protein kinase D (PKD), which has been identified as a regulator of stimulated insulin exocytosis; p38delta catalyzes an inhibitory phosphorylation of PKD1, thereby attenuating stimulated insulin secretion.
ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation.
Review
Hanash et al., New Orleans, United States. In Autoimmunity, 2008
In microarray experiments and real-time RT-PCR assays, we observed significant differences in RNA levels from ICF vs. control lymphoblasts for pro- and anti-apoptotic genes (BCL2L10, CASP1, and PTPN13); nitrous oxide, carbon monoxide, NF-kappaB, and TNFalpha signalling pathway genes (PRKCH, GUCY1A3, GUCY1B3, MAPK13; HMOX1, and MAP4K4); and transcription control genes (NR2F2 and SMARCA2).
Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin.
Review
Eckert et al., Baltimore, United States. In Toxicol Appl Pharmacol, 2007
These actions of EGCG are mediated via activation of a nPKC, Ras, MEKK1, MEK3, p38delta-ERK1/2 signaling cascade which leads to increased activator protein 1 (AP1) and CAATT enhancer binding protein (C/EBP) transcription factor expression, increased binding of these factors to DNA, and increased gene transcription.
Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection.
Review
Muñoz-Cánoves et al., Barcelona, Spain. In Cell Cycle, 2007
However, the relative contribution of the four p38 MAP kinases (p38alpha, p38beta, p38gamma and p38delta) to this process was unknown.
MAP kinases and the control of nuclear events.
Review
Gutkind et al., Bethesda, United States. In Oncogene, 2007
They include the extracellular signal-regulated protein kinases (ERK1 and ERK2); c-Jun N-terminal kinases (JNK1, JNK2, JNK3); p38s (p38alpha, p38beta, p38gamma, p38delta) and ERK5.
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