Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3.
Tokyo, Japan. In Bioorg Med Chem Lett, 2010
Among them, compound 4a, (S)-2-(4-fluorophenyl)-4-(1,2,3,5,6,8a-hexahydroindolizin-7-yl)-3-(pyridin-4-yl)-1H-pyrrole (R-132811), achieved the most promising results in various in vitro and in vivo tests including several rheumatoid arthritis models ((i) inhibition of p38alpha, p38beta, p38gamma, and p38delta MAP kinases: IC(50)=0.034,
p38 MAP-kinases pathway regulation, function and role in human diseases.
Dundee, United Kingdom. In Biochim Biophys Acta, 2007
There are four members of the p38MAPK family (p38alpha, p38beta, p38gamma and p38delta) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities and sensitivities to chemical inhibitors such as SB203580.
MAP kinases and the control of nuclear events.
Bethesda, United States. In Oncogene, 2007
They include the extracellular signal-regulated protein kinases (ERK1 and ERK2); c-Jun N-terminal kinases (JNK1, JNK2, JNK3); p38s (p38alpha, p38beta, p38gamma, p38delta) and ERK5.