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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin-dependent kinase 5, regulatory subunit 1b

Top mentioned proteins: Cyclin-Dependent Kinase 5, PCNA, IL-12, p63, p35
Papers using p35 antibodies
Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells
Jacobson Ken et al., In The Journal of Cell Biology, 1999
... Active cdk5/p35 was purchased from Novagen; active p42MAPK was purchased from New England Biolabs, Inc.; Trypsin (sequencing grade) ...
Papers on p35
(II) Physiological profiling of an endogenous peptide in the basal forebrain: age-related bioactivity and blockade with a novel modulator.
Greenfield et al., United Kingdom. In Neuropharmacology, Feb 2016
Here we show that (1) assemblies are site-specific in their activity profile with the cortex displaying a significantly more extensive network activity than the sub-cortical basal forebrain; (2) there is an age-dependency, in both cortical and sub-cortical sites, with the younger brain (p14 rats) exhibiting more conspicuous assemblies over space and time compared to their older counterparts (p35-40 rats).
Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.
Jeon et al., South Korea. In Mol Neurobiol, Feb 2016
Clozapine upregulated Trk, brain-derived neurotrophic factor, cyclin-dependent kinase-5, and p35 in the cortex and hippocampus of AD mice and activated AMP-activated protein kinase (AMPK).
Evaluation of hematologic composition in newborn C57/BL6 mice up to day 35.
McElroy et al., Iowa City, United States. In Vet Clin Pathol, Jan 2016
Blood samples were obtained via facial vein sampling at postnatal days 0 (p0), p7, p14, p21, p28, or young adulthood (p35).
[Abnormal expression of IL- 23/IL- 17 axis in peripheral blood of 45 patients with primary immune thrombocytopenia].
Wu et al., Suzhou, China. In Zhonghua Xue Ye Xue Za Zhi, Jan 2016
METHODS: The real-time quantitative reverse transcription-polymerase chain reaction(RT-PCR)was used to determine the expression of IL-23p19, p40, p35, IL-23R, IL-12Rβ1, IL-12Rβ2, IL-17A, IL-17F mRNA in the peripheral blood of 45 ITP patients and 30 healthy controls.
Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines.
Singh et al., Rockville, United States. In Cytokine, Nov 2015
Based on recent data that this p40 monomer subsequently associates with p35 released from other cells to generate functional IL-12, we proposed that p40 can function as a DC-derived probe which samples the composition of the local milieu by looking for other binding partners.
Interleukin-12: Functional activities and implications for disease.
Neurath et al., Erlangen, Germany. In Cytokine Growth Factor Rev, Oct 2015
It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-γ production in T and NK cells.
Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases.
Wang et al., Bethesda, United States. In Cytokine Growth Factor Rev, Oct 2015
Although our current understanding of the immunobiology of IL-35 or its subunits (p35 and Ebi3) is still rudimentary, our goal in this review is to summarize what we know about this enigmatic cytokine and its potential clinical use, particularly in the treatment of CNS autoimmune diseases.
[Possible effect of N-Acetyl-L-cysteine on Aβ(25-35)-induced tau hyperphosphorylation].
Chen et al., Fuzhou, China. In Zhonghua Yi Xue Za Zhi, Oct 2015
The proteins of p35/p25, cdk5, pT205 and pS404 were detected by Western blot.
Interleukin-35: Expanding Its Job Profile.
Vignali et al., Pittsburgh, United States. In J Interferon Cytokine Res, Jul 2015
Despite the early predictions for an immunomodulatory role for the Ebi3/p35 heterodimer in placental trophoblasts, IL-35 biology remained elusive until 2007 when it was established as a Treg-restricted inhibitory cytokine.
Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.
Masliah et al., San Diego, United States. In Curr Hiv Res, 2014
CDK5 is activated by binding to its regulatory subunit, p35 or p39.
Interleukin-35 induces regulatory B cells that suppress autoimmune disease.
Egwuagu et al., Bethesda, United States. In Nat Med, 2014
Treatment of mice with IL-35 conferred protection from experimental autoimmune uveitis (EAU), and mice lacking IL-35 (p35 knockout (KO) mice) or defective in IL-35 signaling (IL-12Rβ2 KO mice) produced less Breg cells endogenously or after treatment with IL-35 and developed severe uveitis.
Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment.
Tsai et al., Cambridge, United States. In Cell, 2014
Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35.
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Screaton et al., In Nat Cell Biol, 2014
Here we delineate a complex consisting of the AMPK-related kinase SIK2, the CDK5 activator CDK5R1 (also known as p35) and the E3 ligase PJA2 essential for β-cell functional compensation.
The role of Cdk5 in neuroendocrine thyroid cancer.
Bibb et al., Dallas, United States. In Cancer Cell, 2013
We found that Cdk5 and its cofactors p35 and p25 are highly expressed in human MTC and that Cdk5 activity promotes MTC proliferation.
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.
Heppner et al., Zürich, Switzerland. In Nat Med, 2012
Genetic ablation of the IL-12/IL-23 signaling molecules p40, p35 or p19, in which deficiency of p40 or its receptor complex had the strongest effect, resulted in decreased cerebral amyloid load.
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