The molecular pathogenesis of the myelodysplastic syndromes.
Oxford, United Kingdom. In Eur J Haematol, Jul 2015
Haploinsufficiency of the ribosomal protein gene RPS14 plays a critical role in the development of anemia in the 5q- syndrome, and haploinsufficiency of CUX1 is important in some patients with MDS and AML with complete or partial loss of chromosome 7. Gene expression profiling has identified key deregulated genes and pathways and new prognostic gene signatures in MDS.
The S6K protein family in health and disease.
Limeira, Brazil. In Life Sci, Jul 2015
A third isoform, named p31-S6K1, has been characterized as a truncated type of the protein due to alternative splicing, and reports have shown its important role in cancer.
Recent Advances in the 5q- Syndrome.
Oxford, United Kingdom. In Mediterr J Hematol Infect Dis, 2014
Haploinsufficiency of the ribosomal gene RPS14 has been shown to cause the erythroid defect in the 5q- syndrome.
PP2A: The Achilles Heal in MDS with 5q Deletion.
Tampa, United States. In Front Oncol, 2013
Ineffective erythropoiesis in del(5q) MDS arises from allelic deletion of the ribosomal processing S-14 (RPS14) gene, which leads to MDM2 sequestration with consequent p53 activation and erythroid cell death.
Structure of the mitotic checkpoint complex.
London, United Kingdom. In Nature, 2012
Mad3 and p31(comet) (also known as MAD2L1-binding protein) compete for the same C-Mad2 interface, which explains how p31(comet) disrupts MCC assembly to antagonize the SAC.