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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

E1A binding protein p300

p300, Notch1
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CBP, CAN, p53, V1a
Papers using p300 antibodies
Stabilization of β-catenin induces pancreas tumor formation
Supplier
Fontana Joseph A. et al., In Journal of Oncology, 2007
... -catenin, anti-caspase 3, anti-cleaved caspase-3, and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Supplier
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... Rabbit anti-cleaved Notch1 (Val1744; Cell Signaling Technology), rat anti-importin α1 ...
The role of insulin receptor signaling in zebrafish embryogenesis
Supplier
Bocchetta Maurizio et al., In Oncogene, 2007
... and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); an additional siRNA to Notch-1 was from Qiagen; siRNAs to HIF-1α and ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Supplier
Imperiale Michael, In PLoS Pathogens, 2007
... Purified recombinant FLAG-p300 and recombinant His-AKT1 were purchased from Active Motif.
Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
Supplier
Vij Neeraj, In PLoS ONE, 2006
... Antibodies against IκBα, p50, p65, c-Jun, phospho-p52, phospho-IκB, phospho-IKKα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
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Papers on p300
Lysine Acetyltransferases CBP and p300 Attenuate Transcriptional Activity of the Mineralocorticoid Receptor through its Acetylation.
New
Kim et al., Taegu, South Korea. In Clin Exp Pharmacol Physiol, 24 Mar 2015
We hypothesized that the acetyltransferases CREB-binding protein (CBP) and acetyltransferase p300 (p300) attenuate transcriptional activity of the MR through its acetylation.
A Novel Target for Oral Cancer Chemoprevention? Notch Quite, Yet...
New
El-Naggar et al., Anderson, United States. In Cancer Prev Res (phila), 24 Mar 2015
In this perspective, we comment on the work by Izumchenko et al. that reports a high prevalence of NOTCH1 gain of function mutations in Chinese patients with OPMLs.
NOTCH mutations - multiple faces in human malignancies.
New
Mao, United States. In Cancer Prev Res (phila), 24 Mar 2015
UNASSIGNED: NOTCH proteins have been implicated in multiple cellular functions, such as stem cell maintenance and cell fate determination.
Repression of Ccr9 Transcription in Mouse T Lymphocyte Progenitors by the Notch Signaling Pathway.
New
Kee et al., Chicago, United States. In J Immunol, 20 Mar 2015
In contrast, the canonical Notch signaling pathway prevents the recruitment of p300 to the putative Ccr9 enhancers, resulting in decreased acetylation of histone H3 and a failure to recruit RNA polymerase II to the Ccr9 promoter.
CXCL8 Histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.
New
Knox et al., Nottingham, United Kingdom. In Am J Physiol Lung Cell Mol Physiol, 20 Mar 2015
ASM cells from asthmatic donors had increased histone H3 acetylation, specifically histone H3K18 acetylation, and increased binding of histone acetyltransferase (HAT) p300 compared to non-asthmatics but no differences in CXCL8 DNA methylation.
Comprehensive genomic characterization of head and neck squamous cell carcinomas.
New
Impact
Cancer Genome Atlas Network, In Nature, 01 Mar 2015
A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53.
Role of Uremic Toxins in Erythropoiesis-Stimulating Agent Resistance in Chronic Kidney Disease and Dialysis Patients.
Review
New
Tanaka et al., Tokyo, Japan. In J Ren Nutr, Jan 2015
IS impedes the recruitment of transcriptional coactivators to HIF via upregulation of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 through a mechanism of posttranscriptional messenger RNA stabilization.
Sequencing the head and neck cancer genome: implications for therapy.
Review
New
Califano et al., Baltimore, United States. In Ann N Y Acad Sci, Dec 2014
Emphasis is placed on the therapeutic implications of genes frequently altered in HNSCCs (i.e., TP53, PIK3CA, and NOTCH1) and their corresponding pathways, with a particular focus on recent findings of Notch signaling pathway activation in HNSCC.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
New
Impact
Yang et al., Houston, United States. In Cell, Dec 2014
BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase.
NOTCH signaling roles in acute myeloid leukemia cell growth and interaction with other stemness-related signals.
Review
New
Tohda, Tokyo, Japan. In Anticancer Res, Nov 2014
NOTCH activation plays oncogenic roles in acute T-lymphoblastic leukaemia (T-ALL).
Enhancer activation requires trans-recruitment of a mega transcription factor complex.
New
Impact
Rosenfeld et al., San Diego, United States. In Cell, Nov 2014
The MegaTrans complex is a signature of the most potent functional enhancers and is required for activation of enhancer RNA transcription and recruitment of coactivators, including p300 and Med1.
Genetic landscape of esophageal squamous cell carcinoma.
New
Impact
He et al., Beijing, China. In Nat Genet, Oct 2014
The Hippo and Notch pathways were dysregulated by mutations in FAT1, FAT2, FAT3 or FAT4 (27%) or AJUBA (JUB; 7%) and NOTCH1, NOTCH2 or NOTCH3 (22%) or FBXW7 (5%), respectively.
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
New
Impact
Ferrando et al., New York City, United States. In Nat Med, Oct 2014
Here we identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal duplications in human T cell acute lymphoblastic leukemia (T-ALL).
Friend or foe: can activating mutations in NOTCH1 contribute to a favorable treatment outcome in patients with T-ALL?
Review
Berger et al., Jerusalem, Israel. In Crit Rev Oncog, 2013
Transformation events occur during crucial steps of thymocyte development and have been related to the expression of certain oncogenes such as TAL2, TLX1, LYL1, LMO1, and NOTCH1.
Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia--the possibility to target several kinases through inhibition of the various CDC25 isoforms.
Review
Bruserud et al., Bergen, Norway. In Molecules, 2013
Secondly, high CDC25B expression is associated with resistance against the antiproliferative effect of PI3K-Akt-mTOR inhibitors in primary human AML cells, and inhibition of this isoform seems to reduce AML cell line proliferation through effects on NFκB and p300.
The alarmin IL-33 is a notch target in quiescent endothelial cells.
GeneRIF
Haraldsen et al., Oslo, Norway. In Am J Pathol, 2012
Endothelial nuclear IL-33 is induced by Notch and that Dll4 may be the dominant ligand responsible for this signaling in vivo.
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.
GeneRIF
Kong et al., Seoul, South Korea. In J Clin Invest, 2012
a suppressive role of Notch1 on WNT/beta-catenin target genes involved in colorectal cancer.
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.
GeneRIF
Epstein et al., Philadelphia, United States. In Circulation, 2012
In an in vitro assay in newborn cardiomyocytes, recombinant Notch1 activation caused global changes in the transcriptome & in action potential characteristics, consistent with reprogramming to a conduction-like phenotype.
Acetylation-dependent regulation of Skp2 function.
Impact
GeneRIF
Wei et al., Boston, United States. In Cell, 2012
Studies provide a mechanism whereby acetylation of Skp2 by p300 regulates protein stability and cellular localization, thus modulating oncogenic signaling.
Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
GeneRIF
Banerjee et al., Calcutta, India. In Cell Death Dis, 2011
NOTCH1 intracellular domain induces Akt-dependent upregulation of cytoplasmic EZH2.
More papers using p300 antibodies
Production and purification of lentiviral vectors.
Supplier
Landsberger Nicoletta, In PLoS ONE, 2005
... The antibodies against USF1 (C-20), USF2 (C-20), YY1 (H-414), TFII-I (H-58), p300 (NM11), NF-YA (C-18) and NF-YB (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Recent insights into the role of Notch signaling in tumorigenesis
Supplier
Kawakami T et al., In European Journal of Medical Research, 2005
... examination was carried out using a DAKO EnVision™+Kit (Dako Cytomation, Glostrup, Denmark) with the following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Supplier
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies against cleaved Notch1 (N1ICD) were purchased from Cell Signaling (Saint Quentin en Yvelines, ...
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ
Supplier
Chang Wen-Chang et al., In Nucleic Acids Research, 2002
... Antibodies against COX-2, NF-IL6β, SUMO1 and α-p300-conjugated agarose were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.
Supplier
Nogales-Gadea Gisela, In PLoS ONE, 2002
... Antibodies against IκBα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Supplier
Bergmann Andreas, In PLoS ONE, 1996
... The Notch1 NRR (1 mg/ml) was then cleaved in vitro overnight at 22°C in a total volume of 500 mL using 40 Units of recombinant furin (New England Biolabs, Beverly MA) in 10 ...
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Supplier
Irani Kaikobad et al., In Nucleic Acids Research, 1996
... Antibodies against SIRT1, APE1, Myc-tag and p300 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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