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E1A binding protein p300

p300, Notch1
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CBP, CAN, p53, V1a
Papers using p300 antibodies
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... -catenin, anti-caspase 3, anti-cleaved caspase-3, and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... Rabbit anti-cleaved Notch1 (Val1744; Cell Signaling Technology), rat anti-importin α1 ...
The role of insulin receptor signaling in zebrafish embryogenesis
Bocchetta Maurizio et al., In Oncogene, 2007
... and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); an additional siRNA to Notch-1 was from Qiagen; siRNAs to HIF-1α and ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Imperiale Michael, In PLoS Pathogens, 2007
... Purified recombinant FLAG-p300 and recombinant His-AKT1 were purchased from Active Motif.
Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
Vij Neeraj, In PLoS ONE, 2006
... Antibodies against IκBα, p50, p65, c-Jun, phospho-p52, phospho-IκB, phospho-IKKα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
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Papers on p300
Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation.
Mueller et al., Saarbrücken, Germany. In Learn Mem, Feb 2016
For one we applied garcinol, an inhibitor of the HATs of the p300 (EP300 binding protein)/CBP (CREB-binding protein) family, and the HATs of the PCAF (p300/CBP-associated factor) family.
Prenucleosomes and Active Chromatin.
Kadonaga et al., San Diego, United States. In Cold Spring Harb Symp Quant Biol, Feb 2016
Moreover, p300 acetylates histone H3K56 in prenucleosomes but not in nucleosomes, and H3K56 acetylation is found at active promoters and enhancers.
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
Yang et al., Houston, United States. In Nat Cell Biol, Feb 2016
These events cause HIF1α stabilization, HIF1α-p300 interaction, and activation of HIF1α transcriptional programs under normoxic conditions.
Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.
Cua et al., Palo Alto, United States. In Immunity, Jan 2016
Furthermore, genome-wide occupancy and overexpression studies in Th17 cells revealed that Blimp-1 co-localized with transcription factors RORγt, STAT-3, and p300 at the Il23r, Il17a/f, and Csf2 cytokine loci to enhance their expression.
Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?
Rosenquist et al., Uppsala, Sweden. In J Intern Med, Jan 2016
NOTCH1, SF3B1 and BIRC3).
Chronic lymphocytic leukemia (CLL) - Then and Now.
Jain et al., Houston, United States. In Am J Hematol, Jan 2016
More recently, stereotypy of BCR (B cell receptor) and whole exome sequencing (WES) based discovery of specific mutations such as NOTCH1, TP53, SF3B1, XPO-1, BIRC3, ATM and RPS15 further refined the current prognostication system in CLL.
Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study.
Dombret et al., Marseille, France. In J Clin Oncol, Jan 2016
Multivariate analysis identified serum lactate dehydrogenase level and the NOTCH1/FBXW7/RAS/PTEN oncogene (a four-gene oncogenetic classifier) status but not positron emission tomography or hematopoietic stem cell transplant as independent prognostic factors for outcome in T-LL.
Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation and apoptosis in the neuroblastoma cell line Neuro2a.
Liu et al., Shanghai, China. In Braz J Med Biol Res, Dec 2015
We found that nuclear translocation and acetylation of GAPDH increased in the presence of 5 mM Hcy and that higher levels of acetyltransferase p300/CBP were detected in Neuro2a cells.
hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers.
Deng et al., Xinhui, China. In Mol Oncol, Dec 2015
Furthermore, we demonstrated that the activation of COX-2 expression by hnRNPA2/B1 was mediated through the cooperation with p300, a transcriptional co-activator, in NSCLC cells.
The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis.
Pandey et al., Chicago, United States. In Biol Psychiatry, Dec 2015
Expression of miR-494 was significantly decreased, whereas expression of the binding protein of cyclic adenosine monophosphate response element binding protein (CBP), p300, and Cbp/p300-interacting transactivator 2 (Cited2) was increased in the amygdala during ethanol-induced anxiolysis.
The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.
Chiang et al., Ann Arbor, United States. In Immunity, Dec 2015
Here, we show that similar to Notch1, Zmiz1 was important for T cell development and controlled the expression of certain Notch target genes, such as Myc.
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.
Ferrando et al., New York City, United States. In Nat Med, Oct 2015
Activating mutations in NOTCH1 are common in T cell acute lymphoblastic leukemia (T-ALL).
[Biomarker for Hematopoietic Tumors--Aiming for Personalized Diagnosis of Leukemia Stem Cells].
Tohda, In Rinsho Byori, Sep 2015
In T-lymphoblastic leukemia cells, which often have activating NOTCH1 mutations, NOTCH works in oncogenic signaling.
Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo.
Pincelli et al., Modena, Italy. In Int J Mol Sci, 2014
Similarly, survivin silencing reduces the expression of stem cell markers (OCT4, NOTCH1, CD133, β₁-integrin), while it increases the level of differentiation markers (K10, involucrin).
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Chinnaiyan et al., Ann Arbor, United States. In Genome Med, 2014
Tumors with fusions involving therapeutically targetable genes such as ALK, RET, BRAF, RAF1, FGFR1-4, and NOTCH1-3 have immediate implications for precision medicine across tissue types.
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Haraldsen et al., Oslo, Norway. In Am J Pathol, 2012
Endothelial nuclear IL-33 is induced by Notch and that Dll4 may be the dominant ligand responsible for this signaling in vivo.
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.
Kong et al., Seoul, South Korea. In J Clin Invest, 2012
a suppressive role of Notch1 on WNT/beta-catenin target genes involved in colorectal cancer.
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.
Epstein et al., Philadelphia, United States. In Circulation, 2012
In an in vitro assay in newborn cardiomyocytes, recombinant Notch1 activation caused global changes in the transcriptome & in action potential characteristics, consistent with reprogramming to a conduction-like phenotype.
Acetylation-dependent regulation of Skp2 function.
Wei et al., Boston, United States. In Cell, 2012
Studies provide a mechanism whereby acetylation of Skp2 by p300 regulates protein stability and cellular localization, thus modulating oncogenic signaling.
Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
Banerjee et al., Calcutta, India. In Cell Death Dis, 2011
NOTCH1 intracellular domain induces Akt-dependent upregulation of cytoplasmic EZH2.
More papers using p300 antibodies
Production and purification of lentiviral vectors.
Landsberger Nicoletta, In PLoS ONE, 2005
... The antibodies against USF1 (C-20), USF2 (C-20), YY1 (H-414), TFII-I (H-58), p300 (NM11), NF-YA (C-18) and NF-YB (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Recent insights into the role of Notch signaling in tumorigenesis
Kawakami T et al., In European Journal of Medical Research, 2005
... examination was carried out using a DAKO EnVision™+Kit (Dako Cytomation, Glostrup, Denmark) with the following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies against cleaved Notch1 (N1ICD) were purchased from Cell Signaling (Saint Quentin en Yvelines, ...
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ
Chang Wen-Chang et al., In Nucleic Acids Research, 2002
... Antibodies against COX-2, NF-IL6β, SUMO1 and α-p300-conjugated agarose were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.
Nogales-Gadea Gisela, In PLoS ONE, 2002
... Antibodies against IκBα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Bergmann Andreas, In PLoS ONE, 1996
... The Notch1 NRR (1 mg/ml) was then cleaved in vitro overnight at 22°C in a total volume of 500 mL using 40 Units of recombinant furin (New England Biolabs, Beverly MA) in 10 ...
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Irani Kaikobad et al., In Nucleic Acids Research, 1996
... Antibodies against SIRT1, APE1, Myc-tag and p300 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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