Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.
Davao, Philippines. In Circ Res, 29 Jul 2015
Bach1 overexpression reduces the interaction between p300/CBP and β-catenin, as well as β-catenin acetylation, and chromatin immunoprecipitation experiments confirmed that Bach1 occupies the TCF4-binding site of the IL-8 promoter and recruits histone deacetylase 1 (HDAC1) to the IL-8 promoter in HUVECs.
[Mutations of FBXW7 in Adult T-Cell Acute Lymphocytic Leukemia].
Nanjing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 30 Jun 2015
UNLABELLED: Backgroud: F-Box and WD40 domain containing protein 7 gene (FBXW7) is part of the E3 ubiquitin ligase complex that controls the turnover of various proteins including NOTCH1, c-MYC and Cyclin E. OBJECTIVE: To investigate the mutations of FBXW7 gene in adult T-cell acute lymphoblastic leukemia (T-ALL).
Crosstalk between Nrf2 and notch signaling.
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Pittsburgh, United States. In Free Radic Biol Med, 20 Jun 2015
Data emanating from gene expression microarray analyses comparing Nrf2-disrupted and wild-type mouse embryonic fibroblasts (MEF) showed that expression of Notch1 and Notch-signaling related genes were decreased in Nrf2-disrupted cells.