Notch signaling genes: Myogenic DNA hypomethylation and 5-hydroxymethylcytosine.
Ipswich, United States. In Epigenetics, Jul 2014
Reduced representation bisulfite sequencing (RRBS) indicated significant hypomethylation in myoblasts, myotubes, and skeletal muscle vs. many nonmuscle samples at intragenic or intergenic regions of the following Notch receptor or ligand genes: NOTCH1, NOTCH2, JAG2, and DLL1.
Genome sequencing of lymphoid malignancies.
Memphis, United States. In Blood, Jan 2014
Although each tumor type is characterized by a unique genomic landscape, several cellular pathways are mutated in multiple tumor types-transcriptional regulation of differentiation, antigen receptor signaling, tyrosine kinase and Ras signaling, and epigenetic modifications-and individual genes are mutated in multiple tumors, notably TCF3, NOTCH1, MYD88, and BRAF.
Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes.
New York City, United States. In Front Immunol, Dec 2013
NF-κB is in turn able to influence the chromatin state through a variety of mechanisms, including the recruitment of chromatin modifying co-activator complexes such as p300, the competitive eviction of negative chromatin modifications, and the recruitment of components of the general transcriptional machinery.
More papers using
Novara, Italy. In Adv Exp Med Biol, 2012
Two biomarkers (NOTCH1 mutations and usage of the immunoglobulin VH CDR3 subset 8) may help in identifying CLL patients at risk of DLBCL transformation to be considered for close monitoring and a careful biopsy policy.