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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Jul 2015.

E1A binding protein p300

p300, Notch1
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CBP, CAN, p53, V1a
Papers using p300 antibodies
Stabilization of β-catenin induces pancreas tumor formation
Supplier
Fontana Joseph A. et al., In Journal of Oncology, 2007
... -catenin, anti-caspase 3, anti-cleaved caspase-3, and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Supplier
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... Rabbit anti-cleaved Notch1 (Val1744; Cell Signaling Technology), rat anti-importin α1 ...
The role of insulin receptor signaling in zebrafish embryogenesis
Supplier
Bocchetta Maurizio et al., In Oncogene, 2007
... and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); an additional siRNA to Notch-1 was from Qiagen; siRNAs to HIF-1α and ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Supplier
Imperiale Michael, In PLoS Pathogens, 2007
... Purified recombinant FLAG-p300 and recombinant His-AKT1 were purchased from Active Motif.
Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
Supplier
Vij Neeraj, In PLoS ONE, 2006
... Antibodies against IκBα, p50, p65, c-Jun, phospho-p52, phospho-IκB, phospho-IKKα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
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Papers on p300
Distinctive genotypes in infants with T-cell acute lymphoblastic leukaemia.
New
Ford et al., Rio de Janeiro, Brazil. In Br J Haematol, 24 Aug 2015
Four cases showed NOTCH1 mutations; in one case FBXW7 was the sole mutation and three cases showed alterations in PTEN.
Resveratrol and Curcumin Synergistically Induces Apoptosis in Cigarette Smoke Condensate Transformed Breast Epithelial Cells through a p21(Waf1/Cip1) Mediated Inhibition of Hh-Gli Signaling.
New
Kundu et al., Bhubaneshwar, India. In Int J Biochem Cell Biol, 23 Aug 2015
Interestingly, this combination unaltered the protein expressions of WNT-TCF and Notch signaling components, β-catenin and cleaved notch-1 val1744, respectively.
Targeted sequencing identifies association between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia.
New
Cools et al., Leuven, Belgium. In Haematologica, 23 Aug 2015
NOTCH1 and CDKN2A/B were mutated/deleted in more than half of the cases, while an additional 37 genes were mutated/deleted in 4 to 20% of cases.
Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer.
New
Culig, Innsbruck, Austria. In J Cell Physiol, 22 Aug 2015
Transcriptional integrators p300 and CBP are up-regulated by androgen ablation and may influence antagonist/agonist balance of non-steroidal anti-androgens.
Non-coding recurrent mutations in chronic lymphocytic leukaemia.
New
Impact
Campo et al., Oviedo, Spain. In Nature, 22 Aug 2015
We also identify novel recurrent mutations in non-coding regions, including the 3' region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in a more aggressive disease.
CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.
New
Lazarova et al., Scranton, United States. In World J Gastroenterol, 21 Aug 2015
This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein (CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer (CRC).
TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells.
New
Impact
Li et al., Shanghai, China. In Cell Stem Cell, 02 Aug 2015
Lysine catabolism generates acetyl-CoA, which is used in p300-dependent LRP6 acetylation.
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
New
Impact
Zhang et al., In N Engl J Med, 25 Jul 2015
Their gliomas harbored mutations in CIC, FUBP1, NOTCH1, and the TERT promoter.
Tex10: A New Player in the Core Pluripotency Circuitry.
New
Impact
Buganim, Jerusalem, Israel. In Cell Stem Cell, 04 Jul 2015
(2015) identify a new Sox2-interacting protein, Tex10, which, together with Tet1 and p300, regulate super-enhancers to sustain pluripotency.
Crosstalk between Nrf2 and notch signaling.
Review
New
Kensler et al., Pittsburgh, United States. In Free Radic Biol Med, 20 Jun 2015
Data emanating from gene expression microarray analyses comparing Nrf2-disrupted and wild-type mouse embryonic fibroblasts (MEF) showed that expression of Notch1 and Notch-signaling related genes were decreased in Nrf2-disrupted cells.
The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia.
Review
New
Rosenquist et al., Uppsala, Sweden. In Semin Cancer Biol, 08 Jun 2015
NOTCH1, SF3B1, BIRC3).
What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease.
New
Impact
Mummery et al., Leiden, Netherlands. In Cell Stem Cell, 07 Jun 2015
(2015) used a complex systems biology approach to model vascular aortic calcification caused by mutations in the NOTCH1 gene.
Molecular mechanism of extrinsic factors affecting anti-aging of stem cells.
Review
New
Huang et al., Tainan City, Taiwan. In World J Stem Cells, Apr 2015
Epigenetic regulators such as p300, protein inhibitors of activated Stats and H19 help maintain stem cell quiescence.
Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches.
Review
New
Zimmer et al., Bern, Switzerland. In Cancers (basel), Dec 2014
Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components.
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.
Review
New
Wang et al., Miami, United States. In Front Oncol, Dec 2014
Histone acetyltransferases (HATs), which are the enzymes responsible for histone and non-histone protein acetylation, contain p300/CBP, MYST, and GNAT family members.
The alarmin IL-33 is a notch target in quiescent endothelial cells.
GeneRIF
Haraldsen et al., Oslo, Norway. In Am J Pathol, 2012
Endothelial nuclear IL-33 is induced by Notch and that Dll4 may be the dominant ligand responsible for this signaling in vivo.
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.
GeneRIF
Kong et al., Seoul, South Korea. In J Clin Invest, 2012
a suppressive role of Notch1 on WNT/beta-catenin target genes involved in colorectal cancer.
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.
GeneRIF
Epstein et al., Philadelphia, United States. In Circulation, 2012
In an in vitro assay in newborn cardiomyocytes, recombinant Notch1 activation caused global changes in the transcriptome & in action potential characteristics, consistent with reprogramming to a conduction-like phenotype.
Acetylation-dependent regulation of Skp2 function.
Impact
GeneRIF
Wei et al., Boston, United States. In Cell, 2012
Studies provide a mechanism whereby acetylation of Skp2 by p300 regulates protein stability and cellular localization, thus modulating oncogenic signaling.
Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
GeneRIF
Banerjee et al., Calcutta, India. In Cell Death Dis, 2011
NOTCH1 intracellular domain induces Akt-dependent upregulation of cytoplasmic EZH2.
More papers using p300 antibodies
Production and purification of lentiviral vectors.
Supplier
Landsberger Nicoletta, In PLoS ONE, 2005
... The antibodies against USF1 (C-20), USF2 (C-20), YY1 (H-414), TFII-I (H-58), p300 (NM11), NF-YA (C-18) and NF-YB (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Recent insights into the role of Notch signaling in tumorigenesis
Supplier
Kawakami T et al., In European Journal of Medical Research, 2005
... examination was carried out using a DAKO EnVision™+Kit (Dako Cytomation, Glostrup, Denmark) with the following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Supplier
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies against cleaved Notch1 (N1ICD) were purchased from Cell Signaling (Saint Quentin en Yvelines, ...
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ
Supplier
Chang Wen-Chang et al., In Nucleic Acids Research, 2002
... Antibodies against COX-2, NF-IL6β, SUMO1 and α-p300-conjugated agarose were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.
Supplier
Nogales-Gadea Gisela, In PLoS ONE, 2002
... Antibodies against IκBα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Supplier
Bergmann Andreas, In PLoS ONE, 1996
... The Notch1 NRR (1 mg/ml) was then cleaved in vitro overnight at 22°C in a total volume of 500 mL using 40 Units of recombinant furin (New England Biolabs, Beverly MA) in 10 ...
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Supplier
Irani Kaikobad et al., In Nucleic Acids Research, 1996
... Antibodies against SIRT1, APE1, Myc-tag and p300 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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