GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
E1A binding protein p300
p300, Notch1
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
p300
antibodies
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Supplier
In Cellular and Molecular Life Sciences, 2007
The role of insulin receptor signaling in zebrafish embryogenesis
Supplier
In Oncogene, 2007
... and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); an additional siRNA to Notch-1 was from Qiagen; siRNAs to HIF-1α and ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Supplier
In PLoS Pathogens, 2007
... Purified recombinant FLAG-p300 and recombinant His-AKT1 were purchased from Active Motif.
Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
more suppliersSupplier
In PLoS ONE, 2006
... Antibodies against IκBα, p50, p65, c-Jun, phospho-p52, phospho-IκB, phospho-IKKα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Papers on
p300
Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.
New
Columbus, United States. In Oncogene, 11 Apr 2013
High-risk HPV E6 inactivates p53 through two distinct mechanisms; association with E6AP to degrade p53 and association with p300 to block p300-mediated p53 acetylation and activation.
PCAF acetylates Runx2 and promotes osteoblast differentiation.
New
Huzhou, China. In J Bone Miner Metab, 07 Apr 2013
Here we reported that p300/CBP-associated factor (PCAF) directly binds to Runx2 and acetylates Runx2, leading to an increase in its transcriptional activity.
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.
New
Chiba, Japan. In Proc Natl Acad Sci U S A, 07 Apr 2013
We define a Gata3/Chd4/p300 transcriptional activation complex at the Th2 cytokine loci and a Gata3/Chd4-nucleosome remodeling histone deacetylase repression complex at the Tbx21 locus in Th2 cells.
Skp2 Deficiency Inhibits Chemical Skin Tumorigenesis Independent of p27Kip1 Accumulation.
New
Raleigh, United States. In Am J Pathol, 06 Apr 2013
In addition, Skp2-/- epidermis exhibits an accumulation of p53-cofactor CBP/p300 that is associated with elevated apoptosis in hair follicles and decreased skin tumorigenesis.
Glucagon-induced acetylation of foxa2 regulates hepatic lipid metabolism.
New
Impact
Zürich, Switzerland. In Cell Metab, 05 Apr 2013
Here we show that, in addition, Foxa2 is acetylated at the conserved residue Lys259 following inhibition of histone deacetylases (HDACs) class I-III and the cofactors p300 and SirT1 are involved in Foxa2 acetylation and deacetylation, respectively.
Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer.
New
Impact
Boston, United States. In Cancer Cell, 19 Mar 2013
Notch1 is a rational therapeutic target in several human cancers, but as a transcriptional regulator, it poses a drug discovery challenge.
Regulation of Transcription through Acetylation of H3K122 on the Lateral Surface of the Histone Octamer.
New
Impact
Freiburg, Germany. In Cell, 14 Mar 2013
Furthermore, H3K122ac is catalyzed by the coactivators p300/CBP and can be induced by nuclear hormone receptor signaling.
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.
New
Impact
Madrid, Spain. In Nat Med, 28 Feb 2013
We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin ligase that promotes endocytosis of the NOTCH ligands DELTA and JAGGED, cause LVNC in autosomal-dominant pedigrees, with affected individuals showing reduced NOTCH1 activity and reduced expression of target genes.
The significance of notch1 compared with notch3 in high metastasis and poor overall survival in hepatocellular carcinoma.
New
Xi'an, China. In Plos One, Dec 2012
Notch1 and Notch3 may be involved in malignant transformation, although their roles remain unknown.
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
New
Impact
Vancouver, Canada. In Nat Med, Nov 2012
We also show that PKC-θ is regulated by a new pathway in which NOTCH1 induces runt-related transcription factor 3 (RUNX3), RUNX3 represses RUNX1 and RUNX1 induces PKC-θ.
Effects of transcranial magnetic stimulation on the cognitive event-related potential p300: a literature review.
Review
New
Teresina, Brazil. In Clin Eeg Neurosci, Oct 2012
The objective of this study was to perform a systematic review regarding the effects of transcranial magnetic stimulation (TMS) on the cognitive event-related potential P300.
Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.
Review
New
Villejuif, France. In Leukemia, Sep 2012
On the other hand, some mutations (for example, NOTCH1) occur in both CLL and other immature and mature lymphoid malignancies.
The role of CaMKII in regulating GLUT4 expression in skeletal muscle.
Review
New
Cape Town, South Africa. In Am J Physiol Endocrinol Metab, Sep 2012
Experimental evidence showing that CaMK activation induces hyperacetylation of histones in the vicinity of the MEF2 domain and increases MEF2 binding to its cis element to influence MEF2-dependent Glut4 gene expression are also given along with data suggesting that p300 might be involved in acetylating histones on the Glut4 gene.
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.
GeneRIF
Chicago, United States. In Proc Natl Acad Sci U S A, 2012
Tcf-1 is shown to be a gatekeeper of T-cell fate and Tcf-1 is directly activated by Notch signals.
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Impact
GeneRIF
Ann Arbor, United States. In Nat Med, 2011
Both MAST and Notch-family gene fusions have substantial phenotypic effects in breast epithelial cells.
Recent advances on NOTCH signaling in T-ALL.
Review
New York City, United States. In Curr Top Microbiol Immunol, 2011
In addition, a number of emerging anti-NOTCH therapeutic strategies including anti-NOTCH1 inhibitory antibodies, small peptide inhibitors of NOTCH signaling and combination therapies with GSIs and glucocorticoids, have recently been proposed.
Novel insights in molecular mechanisms of CLL.
Review
Columbus, United States. In Curr Pharm Des, 2011
Analysis of CLL coding genome identified NOTCH1 as a frequent target of activating mutations.
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.
GeneRIF
Turku, Finland. In Proc Natl Acad Sci U S A, 2011
Notch has a role in cellular energy homeostasis, and Notch signaling is required for metabolic flexibility
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
GeneRIF
Berkeley, United States. In Proc Natl Acad Sci U S A, 2011
study describes a spectrum of inactivating somatic mutations of Notch receptors in lung and skin cancers, indicating that Notch loss of function plays a prominent role in multiple variants of squamous cell carcinomas
Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.
More papers using
p300
antibodies
GeneRIF
Boston, United States. In Plos One, 2010
The Notch ankyrin repeat domains differ in their leukemogenic potential, and that this difference correlates with activation of Myc.
Production and purification of lentiviral vectors.
Supplier
In PLoS ONE, 2005
... The antibodies against USF1 (C-20), USF2 (C-20), YY1 (H-414), TFII-I (H-58), p300 (NM11), NF-YA (C-18) and NF-YB (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Recent insights into the role of Notch signaling in tumorigenesis
Supplier
In European Journal of Medical Research, 2005
... examination was carried out using a DAKO EnVision™+Kit (Dako Cytomation, Glostrup, Denmark) with the following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Supplier
In Breast Cancer Research : BCR, 2004
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ
Supplier
In Nucleic Acids Research, 2002
... Antibodies against COX-2, NF-IL6β, SUMO1 and α-p300-conjugated agarose were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.
Supplier
In PLoS ONE, 2002
... Antibodies against IκBα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Supplier
In PLoS ONE, 1996
... The Notch1 NRR (1 mg/ml) was then cleaved in vitro overnight at 22°C in a total volume of 500 mL using 40 Units of recombinant furin (New England Biolabs, Beverly MA) in 10 ...
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Supplier
In Nucleic Acids Research, 1996
... Antibodies against SIRT1, APE1, Myc-tag and p300 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
