HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.
Corvallis, United States. In Cell Death Dis, Dec 2013
On the corresponding BMF gene promoter, loss of HDAC8 was associated with signal transducer and activator of transcription 3 (STAT3)/specificity protein 3 (Sp3) transcription factor exchange and recruitment of p300.
New Approaches to Target T-ALL.
Boston, United States. In Front Oncol, Dec 2013
This review will summarize recent advancements in the study of inhibiting the NOTCH1, PI3K-AKT, and Cyclin D3:CDK4/6 pathways as therapeutic strategies for T-ALL.
Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes.
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New York City, United States. In Front Immunol, Dec 2013
NF-κB is in turn able to influence the chromatin state through a variety of mechanisms, including the recruitment of chromatin modifying co-activator complexes such as p300, the competitive eviction of negative chromatin modifications, and the recruitment of components of the general transcriptional machinery.