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E1A binding protein p300

p300, Notch1
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CBP, CAN, p53, V1a
Papers using p300 antibodies
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... -catenin, anti-caspase 3, anti-cleaved caspase-3, and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... Rabbit anti-cleaved Notch1 (Val1744; Cell Signaling Technology), rat anti-importin α1 ...
The role of insulin receptor signaling in zebrafish embryogenesis
Bocchetta Maurizio et al., In Oncogene, 2007
... and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); an additional siRNA to Notch-1 was from Qiagen; siRNAs to HIF-1α and ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Imperiale Michael, In PLoS Pathogens, 2007
... Purified recombinant FLAG-p300 and recombinant His-AKT1 were purchased from Active Motif.
Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
Vij Neeraj, In PLoS ONE, 2006
... Antibodies against IκBα, p50, p65, c-Jun, phospho-p52, phospho-IκB, phospho-IKKα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
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Papers on p300
NOTCH1 and FBXW7 Mutations Favour Better Outcome in Pediatric South Indian T-Cell Acute Lymphoblastic Leukemia.
Karunakaran et al., Heidelberg, Germany. In J Pediatr Hematol Oncol, 09 Jan 2015
Mutations in NOTCH1/FBXW7 activate NOTCH signaling and are of prognostic significance in patients with T-cell acute lymphoblastic leukemia (T-ALL).
Mapping Residual Structure in Intrinsically Disordered Proteins at Residue Resolution Using Millisecond Hydrogen/Deuterium Exchange and Residue Averaging.
Weis et al., Lawrence, United States. In J Am Soc Mass Spectrom, 07 Jan 2015
We validated this approach both by simulating a disordered protein and experimentally using the p300 binding domain of ACTR, a model disordered protein already well-characterized by other approaches.
Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.
Geoerger et al., Nutley, United States. In Anticancer Drugs, 06 Jan 2015
UNLABELLED: Notch signaling is altered in many cancers.
lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals.
Yang et al., Houston, United States. In Cell, 20 Dec 2014
BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase.
Histone H3 K27 acetylation marks a potent enhancer element on the adipogenic master regulator gene Pparg2.
Xu et al., Singapore, Singapore. In Cell Cycle, 01 Dec 2014
Further studies identified a binding site for p300 as the essential enhancer element in CNS10.
How to teach an old dog new tricks: Autophagy-independent action of chloroquine on the tumor vasculature.
Agostinis et al., In Autophagy, 30 Nov 2014
CQ-induced vessel normalization rely mainly on altered endolysosomal trafficking and sustained NOTCH1 signaling in ECs.
NOTCH Signaling Roles in Acute Myeloid Leukemia Cell Growth and Interaction with other Stemness-related Signals.
Tohda, Tokyo, Japan. In Anticancer Res, 30 Nov 2014
UNLABELLED: NOTCH activation plays oncogenic roles in acute T-lymphoblastic leukaemia (T-ALL).
Enhancer activation requires trans-recruitment of a mega transcription factor complex.
Rosenfeld et al., San Diego, United States. In Cell, 09 Nov 2014
The MegaTrans complex is a signature of the most potent functional enhancers and is required for activation of enhancer RNA transcription and recruitment of coactivators, including p300 and Med1.
Required enhancer-matrin-3 network interactions for a homeodomain transcription program.
Rosenfeld et al., San Diego, United States. In Nature, 09 Nov 2014
The matrin-3 network-tethered R271W Pit1 mutant, but not the untethered protein, restores Pit1-dependent activation of the enhancers and recruitment of co-activators, exemplified by p300, causing both enhancer RNA transcription and target gene activation.
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Ferrando et al., New York City, United States. In Nat Med, Oct 2014
Here we identify a new long range-acting MYC enhancer controlled by NOTCH1 that is targeted by recurrent chromosomal duplications in human T cell acute lymphoblastic leukemia (T-ALL).
Genetic landscape of esophageal squamous cell carcinoma.
He et al., Beijing, China. In Nat Genet, Oct 2014
The Hippo and Notch pathways were dysregulated by mutations in FAT1, FAT2, FAT3 or FAT4 (27%) or AJUBA (JUB; 7%) and NOTCH1, NOTCH2 or NOTCH3 (22%) or FBXW7 (5%), respectively.
New Approaches to Target T-ALL.
Stegmaier et al., Boston, United States. In Front Oncol, Dec 2013
This review will summarize recent advancements in the study of inhibiting the NOTCH1, PI3K-AKT, and Cyclin D3:CDK4/6 pathways as therapeutic strategies for T-ALL.
Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes.
Ghosh et al., New York City, United States. In Front Immunol, Dec 2013
NF-κB is in turn able to influence the chromatin state through a variety of mechanisms, including the recruitment of chromatin modifying co-activator complexes such as p300, the competitive eviction of negative chromatin modifications, and the recruitment of components of the general transcriptional machinery.
Therapeutic Targeting the Cell Division Cycle 25 (CDC25) Phosphatases in Human Acute Myeloid Leukemia - The Possibility to Target Several Kinases through Inhibition of the Various CDC25 Isoforms.
Bruserud et al., Bergen, Norway. In Molecules, Dec 2013
Secondly, high CDC25B expression is associated with resistance against the antiproliferative effect of PI3K-Akt-mTOR inhibitors in primary human AML cells, and inhibition of this isoform seems to reduce AML cell line proliferation through effects on NFκB and p300.
Learning tasks as a possible treatment for DNA lesions induced by oxidative stress in hippocampal neurons.
Silaghi-Dumitrescu et al., Bucureşti, Romania. In Neural Regen Res, Dec 2013
Studies from molecular biology have shown that the protein p300, which is a transcription co-activator required for consolidation of memories during specific learning tasks, is at the same time involved in DNA replication and repair, playing a central role in the long-patch pathway of base excision repair.
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.
Kong et al., Seoul, South Korea. In J Clin Invest, 2012
a suppressive role of Notch1 on WNT/beta-catenin target genes involved in colorectal cancer.
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Haraldsen et al., Oslo, Norway. In Am J Pathol, 2012
Endothelial nuclear IL-33 is induced by Notch and that Dll4 may be the dominant ligand responsible for this signaling in vivo.
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.
Epstein et al., Philadelphia, United States. In Circulation, 2012
In an in vitro assay in newborn cardiomyocytes, recombinant Notch1 activation caused global changes in the transcriptome & in action potential characteristics, consistent with reprogramming to a conduction-like phenotype.
Acetylation-dependent regulation of Skp2 function.
Wei et al., Boston, United States. In Cell, 2012
Studies provide a mechanism whereby acetylation of Skp2 by p300 regulates protein stability and cellular localization, thus modulating oncogenic signaling.
Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
Banerjee et al., Calcutta, India. In Cell Death Dis, 2011
NOTCH1 intracellular domain induces Akt-dependent upregulation of cytoplasmic EZH2.
More papers using p300 antibodies
Production and purification of lentiviral vectors.
Landsberger Nicoletta, In PLoS ONE, 2005
... The antibodies against USF1 (C-20), USF2 (C-20), YY1 (H-414), TFII-I (H-58), p300 (NM11), NF-YA (C-18) and NF-YB (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Recent insights into the role of Notch signaling in tumorigenesis
Kawakami T et al., In European Journal of Medical Research, 2005
... examination was carried out using a DAKO EnVision™+Kit (Dako Cytomation, Glostrup, Denmark) with the following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies against cleaved Notch1 (N1ICD) were purchased from Cell Signaling (Saint Quentin en Yvelines, ...
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ
Chang Wen-Chang et al., In Nucleic Acids Research, 2002
... Antibodies against COX-2, NF-IL6β, SUMO1 and α-p300-conjugated agarose were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.
Nogales-Gadea Gisela, In PLoS ONE, 2002
... Antibodies against IκBα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Bergmann Andreas, In PLoS ONE, 1996
... The Notch1 NRR (1 mg/ml) was then cleaved in vitro overnight at 22°C in a total volume of 500 mL using 40 Units of recombinant furin (New England Biolabs, Beverly MA) in 10 ...
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Irani Kaikobad et al., In Nucleic Acids Research, 1996
... Antibodies against SIRT1, APE1, Myc-tag and p300 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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