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E1A binding protein p300

p300, Notch1
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CBP, CAN, p53, V1a
Papers using p300 antibodies
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... -catenin, anti-caspase 3, anti-cleaved caspase-3, and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... Rabbit anti-cleaved Notch1 (Val1744; Cell Signaling Technology), rat anti-importin α1 ...
The role of insulin receptor signaling in zebrafish embryogenesis
Bocchetta Maurizio et al., In Oncogene, 2007
... and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); an additional siRNA to Notch-1 was from Qiagen; siRNAs to HIF-1α and ...
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Imperiale Michael, In PLoS Pathogens, 2007
... Purified recombinant FLAG-p300 and recombinant His-AKT1 were purchased from Active Motif.
Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
Vij Neeraj, In PLoS ONE, 2006
... Antibodies against IκBα, p50, p65, c-Jun, phospho-p52, phospho-IκB, phospho-IKKα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
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Papers on p300
Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer.
Culig, Innsbruck, Austria. In J Cell Physiol, 29 Feb 2016
Transcriptional integrators p300 and CBP are up-regulated by androgen ablation and may influence antagonist/agonist balance of non-steroidal anti-androgens.
CD49d (ITGA4) expression is a predictor of time to first treatment in patients with chronic lymphocytic leukaemia and mutated IGHV status.
Montserrat et al., Barcelona, Spain. In Br J Haematol, 12 Dec 2015
A high expression of CD49d (>30%) was found in 142/415 (34%) patients and was associated with progressive disease (advanced clinical stage, high serum lactate dehydrogenase or β2 -microglobulin levels; all p < 0·05) and aggressive disease biology (increased ZAP70 or CD38, unmutated IGHV, trisomy 12, mutations of NOTCH1 and SF3B1; all P < 0·05).
The cellular protein complex associated with a transforming region of E1A contains c-MYC.
Chinnadurai et al., Saint Louis, United States. In J Virol, 11 Dec 2015
UNASSIGNED: The cell transforming activity of HAdV5 E1A is mediated by the N-terminal half of E1A which interacts with three different major cellular protein complexes, p300/CBP, TRRAP/p400 and pRb family members.
LPL gene expression is associated with poor prognosis in CLL and closely related to NOTCH1 mutations.
Møller et al., Odense, Denmark. In Eur J Haematol, 11 Dec 2015
AIM: To evaluate LPL gene expression together with the well-established prognostic markers of CLL and investigate correlations with more recently identified prognostic markers, NOTCH1 and TP53 mutations.
Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.
Iruela-Arispe et al., Los Angeles, United States. In J Exp Med, 09 Dec 2015
Here we identified NOTCH1 as an antagonist of endothelial cell (EC) activation.
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy.
Knapp et al., Oxford, United Kingdom. In Cancer Res, 09 Dec 2015
UNASSIGNED: The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth.
Crosstalk between Nrf2 and Notch signaling.
Kensler et al., Pittsburgh, United States. In Free Radic Biol Med, 30 Nov 2015
Data emanating from gene expression microarray analyses comparing Nrf2-disrupted and wild-type mouse embryonic fibroblasts (MEF) showed that expression of Notch1 and Notch-signaling-related genes were decreased in Nrf2-disrupted cells.
The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.
Chiang et al., Ann Arbor, United States. In Immunity, 27 Nov 2015
Here, we show that similar to Notch1, Zmiz1 was important for T cell development and controlled the expression of certain Notch target genes, such as Myc.
Non-coding recurrent mutations in chronic lymphocytic leukaemia.
Campo et al., Oviedo, Spain. In Nature, 22 Nov 2015
We also identify novel recurrent mutations in non-coding regions, including the 3' region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in a more aggressive disease.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Gan et al., San Francisco, United States. In Nat Med, 31 Oct 2015
Acetyltransferase p300-induced tau acetylation is inhibited by salsalate and salicylate, which enhance tau turnover and reduce tau levels.
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.
Ferrando et al., New York City, United States. In Nat Med, 31 Oct 2015
Activating mutations in NOTCH1 are common in T cell acute lymphoblastic leukemia (T-ALL).
CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.
Lazarova et al., Scranton, United States. In World J Gastroenterol, Aug 2015
This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein (CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer (CRC).
TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells.
Li et al., Shanghai, China. In Cell Stem Cell, Aug 2015
Lysine catabolism generates acetyl-CoA, which is used in p300-dependent LRP6 acetylation.
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.
Wang et al., Miami, United States. In Front Oncol, Dec 2014
Histone acetyltransferases (HATs), which are the enzymes responsible for histone and non-histone protein acetylation, contain p300/CBP, MYST, and GNAT family members.
Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives.
Yang et al., Rochester, United States. In Dis Markers, Dec 2014
Recent studies have shown that NOTCH1 is a critical regulator of human carcinogenesis and has been implicated in multiple steps of cancer development and progression.
The alarmin IL-33 is a notch target in quiescent endothelial cells.
Haraldsen et al., Oslo, Norway. In Am J Pathol, 2012
Endothelial nuclear IL-33 is induced by Notch and that Dll4 may be the dominant ligand responsible for this signaling in vivo.
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer.
Kong et al., Seoul, South Korea. In J Clin Invest, 2012
a suppressive role of Notch1 on WNT/beta-catenin target genes involved in colorectal cancer.
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.
Epstein et al., Philadelphia, United States. In Circulation, 2012
In an in vitro assay in newborn cardiomyocytes, recombinant Notch1 activation caused global changes in the transcriptome & in action potential characteristics, consistent with reprogramming to a conduction-like phenotype.
Acetylation-dependent regulation of Skp2 function.
Wei et al., Boston, United States. In Cell, 2012
Studies provide a mechanism whereby acetylation of Skp2 by p300 regulates protein stability and cellular localization, thus modulating oncogenic signaling.
Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
Banerjee et al., Calcutta, India. In Cell Death Dis, 2011
NOTCH1 intracellular domain induces Akt-dependent upregulation of cytoplasmic EZH2.
More papers using p300 antibodies
Production and purification of lentiviral vectors.
Landsberger Nicoletta, In PLoS ONE, 2005
... The antibodies against USF1 (C-20), USF2 (C-20), YY1 (H-414), TFII-I (H-58), p300 (NM11), NF-YA (C-18) and NF-YB (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Recent insights into the role of Notch signaling in tumorigenesis
Kawakami T et al., In European Journal of Medical Research, 2005
... examination was carried out using a DAKO EnVision™+Kit (Dako Cytomation, Glostrup, Denmark) with the following 2 antibodies: Notch1 rabbit polyclonal antibody (ab27526, Abcam plc, Cambridge; dilution: 1/1000; ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies against cleaved Notch1 (N1ICD) were purchased from Cell Signaling (Saint Quentin en Yvelines, ...
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ
Chang Wen-Chang et al., In Nucleic Acids Research, 2002
... Antibodies against COX-2, NF-IL6β, SUMO1 and α-p300-conjugated agarose were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.
Nogales-Gadea Gisela, In PLoS ONE, 2002
... Antibodies against IκBα and Notch1 were purchased from Santa Cruz Biotechnology (San Diego, CA) ...
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Bergmann Andreas, In PLoS ONE, 1996
... The Notch1 NRR (1 mg/ml) was then cleaved in vitro overnight at 22°C in a total volume of 500 mL using 40 Units of recombinant furin (New England Biolabs, Beverly MA) in 10 ...
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Irani Kaikobad et al., In Nucleic Acids Research, 1996
... Antibodies against SIRT1, APE1, Myc-tag and p300 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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