Glucagon-induced acetylation of foxa2 regulates hepatic lipid metabolism.
Zürich, Switzerland. In Cell Metab, 05 Apr 2013
Here we show that, in addition, Foxa2 is acetylated at the conserved residue Lys259 following inhibition of histone deacetylases (HDACs) class I-III and the cofactors p300 and SirT1 are involved in Foxa2 acetylation and deacetylation, respectively.
The role of CaMKII in regulating GLUT4 expression in skeletal muscle.
Cape Town, South Africa. In Am J Physiol Endocrinol Metab, Sep 2012
Experimental evidence showing that CaMK activation induces hyperacetylation of histones in the vicinity of the MEF2 domain and increases MEF2 binding to its cis element to influence MEF2-dependent Glut4 gene expression are also given along with data suggesting that p300 might be involved in acetylating histones on the Glut4 gene.
Recent advances on NOTCH signaling in T-ALL.
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New York City, United States. In Curr Top Microbiol Immunol, 2011
In addition, a number of emerging anti-NOTCH therapeutic strategies including anti-NOTCH1 inhibitory antibodies, small peptide inhibitors of NOTCH signaling and combination therapies with GSIs and glucocorticoids, have recently been proposed.