c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy:role of COX-2 induction.
Taiwan. In Mol Cell Endocrinol, 10 May 2015
In this study, thrombin-induced COX-2 promoter activity, mRNA and protein expression, and PGE2 synthesis was attenuated by pretreatment with the inhibitors of c-Src (PP1), Pyk2 (PF431396), EGFR (AG1478), PI3K/Akt (LY294002/SH-5), and p300 (GR343), or transfection with siRNAs of c-Src, Pyk2, EGFR, p110, Akt, CREB, and p300.
Sequencing the head and neck cancer genome: implications for therapy.
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Baltimore, United States. In Ann N Y Acad Sci, Dec 2014
Emphasis is placed on the therapeutic implications of genes frequently altered in HNSCCs (i.e., TP53, PIK3CA, and NOTCH1) and their corresponding pathways, with a particular focus on recent findings of Notch signaling pathway activation in HNSCC.