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Purinergic receptor P2Y, G-protein coupled, 2

P2Y2, P2U
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: P2Y, V1a, ACID, HAD, CAN
Papers on P2Y2
Purinergic signaling in scarring.
Review
New
Cronstein et al., Ferrara, Italy. In Faseb J, Jan 2016
P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have been shown to have profibrotic effects, as well.
Pentosan Polysulfate Preserves Renal Microvascular P2X1 Receptor Reactivity and Autoregulatory Behavior in DOCA-salt Hypertensive Rats.
New
Inscho et al., Birmingham, United States. In Am J Physiol Renal Physiol, Jan 2016
Arteriolar responses to adenosine and UTP (P2Y2 receptor agonist) were unaffected by DOCA-salt treatment.
ATP releases ATP or other nucleotides from human peripheral blood leukocytes through purinergic P2 receptors.
New
Montaño et al., Mexico. In Life Sci, Jan 2016
SIGNIFICANCE: 500μM ATP induced the release of ATP or other nucleotides through activation of P2Y2,4,6,11 receptors in human leukocytes, and probably via P2X receptors at higher concentrations.
Purinergic Receptor P2Y2 Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: New AP-1 Transcription Factor Site and Negative Regulator.
New
Shen et al., Auburn, United States. In J Biol Chem, Jan 2016
UNASSIGNED: We recently reported that the P2Y2 receptor (P2Y2R) is the predominant nucleotide receptor expressed in human coronary artery endothelial cells (HCAEC), and that P2Y2R activation by ATP or UTP induces dramatic up-regulation of tissue factor (TF), a key initiator of the coagulation cascade.
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation.
New
Alves et al., Rio de Janeiro, Brazil. In Plos One, Dec 2015
Next we evaluate by microfluorimetry the expression of P2Y receptors, our results based in the ranking order of potency (UTP>ATPγS> ATP > UDP> ADP >2meSATP > αβmeATP) suggests the presence of P2Y2, P2Y4, P2Y6 and P2Y11.
Epithelial Cell-Derived Cytokines Contribute to the Pathophysiology of Eosinophilic Chronic Rhinosinusitis.
New
Shimizu et al., Ōtsu, Japan. In J Interferon Cytokine Res, Dec 2015
Nasal tissue specimens from chronic rhinosinusitis patients were assayed for the expression of TSLP, IL-25, IL-33, protease-activated receptor (PAR)-2, and P2Y2 receptor (P2Y2R).
Purinergic Receptors in Thrombosis and Inflammation.
Review
New
Gachet et al., Strasbourg, France. In Arterioscler Thromb Vasc Biol, Nov 2015
Beyond platelets, these 3 receptors, along with the P2Y2, P2Y6, and P2X7 receptors, constitute the main P2 receptors mediating the proinflammatory effects of nucleotides, which play important roles in various functions of circulating blood cells and cells of the vessel wall.
Pharmacology and structure of P2Y receptors.
Review
New
Hoffmann et al., Bonn, Germany. In Neuropharmacology, Nov 2015
There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14).
Purinergic receptors in embryonic and adult neurogenesis.
Review
New
Ulrich et al., São Paulo, Brazil. In Neuropharmacology, Nov 2015
While several P2 receptor subtypes were shown to be expressed during in vitro and in vivo neurogenesis, specific functions have been proposed for P2Y1, P2Y2 metabotropic as well as P2X2 ionotropic receptors to promote neurogenesis.
Purinergic transmission in blood vessels.
Review
New
Dunn et al., Nottingham, United Kingdom. In Auton Neurosci, Sep 2015
P2Y2, P2Y4 and P2Y6 receptors expressed on the vascular smooth muscle are coupled to vasocontraction, and may have a role in pathophysiological conditions, when purines are released from damaged cells, or when there is damage to the protective barrier that is the endothelium.
A functional landscape of resistance to ALK inhibition in lung cancer.
New
Impact
Garraway et al., Boston, United States. In Cancer Cell, Apr 2015
Among the latter were members of the P2Y purinergic receptor family of G-protein-coupled receptors (P2Y1, P2Y2, and P2Y6).
Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.
Impact
Offermanns et al., Bad Nauheim, Germany. In Cancer Cell, 2013
We identified the endothelial P2Y2 receptor, which is activated by ATP, as the primary mediator of this effect.
Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
GeneRIF
Lemoli et al., Bologna, Italy. In J Immunol, 2012
Adenosine triphosphate (ATP) enhances proliferation, adhesion, and migration via P2Y2R activation and the immunosuppressive ability of regulatory T (Treg) cells.
P2Y(2) receptor expression is regulated by C/EBPβ during inflammation in intestinal epithelial cells.
GeneRIF
Gendron et al., Sherbrooke, Canada. In Febs J, 2012
Although C/EBPbeta was sufficient to induce P2Y(2) transcription, the effect of C/EBPbeta and NF-kappaB p65 on receptor transcription was synergistic.
Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling.
GeneRIF
Kishore et al., Salt Lake City, United States. In Am J Physiol Renal Physiol, 2012
genetic deletion of P2Y2-R offers significant resistance to the development of Li-induced polyuria, without altering blood Li levels and renal accumulation of Li, and suppression of PGE2 production
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.
GeneRIF
Hanley et al., Münster, Germany. In J Biol Chem, 2012
P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.
Teasing out the role of ATP in immune responses. See referenced article, J. Biol. Chem. 2011, 286, 44776–44787. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.
GeneRIF
In J Biol Chem, 2012
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.
Impact
GeneRIF
Junger et al., San Diego, United States. In Science, 2007
ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils
Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor.
Impact
Jankowski et al., Berlin, Germany. In Nat Med, 2005
Up(4)A is likely to exert vasoconstriction predominantly through P2X1 receptors, and probably also through P2Y2 and P2Y4 receptors.
G-protein-coupled receptors as targets for gene transfer vectors using natural small-molecule ligands.
Impact
Boucher et al., Chapel Hill, United States. In Nat Biotechnol, 2000
The G-protein-coupled P2Y2 receptor (P2Y2-R) is abundantly expressed on the airway lumenal surface and internalizes into coated pits upon agonist activation.
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