Purinergic signaling in scarring.
Ferrara, Italy. In Faseb J, Jan 2016
P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have been shown to have profibrotic effects, as well.
Purinergic Receptors in Thrombosis and Inflammation.
Strasbourg, France. In Arterioscler Thromb Vasc Biol, Nov 2015
Beyond platelets, these 3 receptors, along with the P2Y2, P2Y6, and P2X7 receptors, constitute the main P2 receptors mediating the proinflammatory effects of nucleotides, which play important roles in various functions of circulating blood cells and cells of the vessel wall.
Purinergic receptors in embryonic and adult neurogenesis.
São Paulo, Brazil. In Neuropharmacology, Nov 2015
While several P2 receptor subtypes were shown to be expressed during in vitro and in vivo neurogenesis, specific functions have been proposed for P2Y1, P2Y2 metabotropic as well as P2X2 ionotropic receptors to promote neurogenesis.
Purinergic transmission in blood vessels.
Nottingham, United Kingdom. In Auton Neurosci, Sep 2015
P2Y2, P2Y4 and P2Y6 receptors expressed on the vascular smooth muscle are coupled to vasocontraction, and may have a role in pathophysiological conditions, when purines are released from damaged cells, or when there is damage to the protective barrier that is the endothelium.