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Purinergic receptor P2Y, G-protein coupled, 1

P2Y, P2Y1
G protein-coupled receptor for extracellular ATP; plays a role in ischemic preconditioning (IPC) in heart [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, CAN, P2Y12, HAD, ACID
Papers using P2Y antibodies
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Beaudoin Claude, In PLoS ONE, 2009
... The antibody to P2Y13 was obtained from Abcam (Cambridge, MA) ...
P2Y receptor activation affects the proliferation and differentiation of glial and neuronal cells: a focus on rat C6 glioma cells
Barańska Jolanta et al., In Purinergic Signalling, 2003
... , and P2Y12 were purchased from Alomone and Sigma Aldrich Chemical labs ...
Ten years of protein kinase B signalling: a hard Akt to follow
Krügel U. et al., In Purinergic Signalling, 2000
... , anti-P2Y12 (rabbit; Alomone Labs, Jerusalem, Israel), anti-P2Y ...
Ageing and hair cycles
Burnstock Geoffrey et al., In Purinergic Signalling, 1994
... and P2Y2 antibodies were obtained from Alomone Labs (Jerusalem, Israel) and corresponded ...
Papers on P2Y
Mesenchymal Stem Cells Ageing: Targeting the "Purinome" to Promote Osteogenic Differentiation and Bone Repair.
Correia-de-Sá et al., Porto, Portugal. In J Cell Physiol, Feb 2016
Nucleotides and their derivatives act via adenosine P1 (A1 , A2A , A2B and A3 ) and nucleotide-sensitive P2 purinoceptors comprising ionotropic P2X and G-protein-coupled P2Y receptors.
Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.
Nedergaard et al., Copenhagen, Denmark. In Proc Natl Acad Sci U S A, Feb 2016
We show here that following blood-brain barrier (BBB) breakdown, P2RY12 (purinergic receptor P2Y, G-protein coupled, 12)-mediated chemotaxis of microglia processes is required for the rapid closure of the BBB.
Thymidine 5'-O-monophosphorothioate induces HeLa cell migration by activation of the P2Y6 receptor.
Szustak et al., Łódź, Poland. In Purinergic Signal, Feb 2016
UNASSIGNED: ATP, ADP, UTP, and UDP acting as ligands of specific P2Y receptors activate intracellular signaling cascades to regulate a variety of cellular processes, including proliferation, migration, differentiation, and cell death.
Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Przyklenk et al., Vienna, Austria. In Arterioscler Thromb Vasc Biol, Feb 2016
OBJECTIVE: Unlike currently approved adenosine diphosphate receptor antagonists, the new diadenosine tetraphosphate derivative GLS-409 targets not only P2Y12 but also the second human platelet adenosine diphosphate receptor P2Y1 and may, therefore, be a promising antiplatelet drug candidate.
Dual Modulation of Nociception and Cardiovascular Reflexes during Peripheral Ischemia through P2Y1 Receptor-Dependent Sensitization of Muscle Afferents.
Jankowski et al., Cincinnati, United States. In J Neurosci, Feb 2016
Behaviors also corresponded to specific upregulation of the ADP-responsive P2Y1 receptor in the DRGs.
Medicinal chemistry of adenosine, P2Y and P2X receptors.
Müller et al., Bethesda, United States. In Neuropharmacology, Jan 2016
UNASSIGNED: Pharmacological tool compounds are now available to define action at the adenosine (ARs), P2Y and P2X receptors.
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation.
Alves et al., Rio de Janeiro, Brazil. In Plos One, Dec 2015
Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y receptors.
Purinergic signalling in brain ischemia.
Pugliese et al., Florence, Italy. In Neuropharmacology, Dec 2015
Among P2Y receptors, antagonists of P2Y12 receptors are of value because of their antiplatelet activity and possibly because of additional anti-inflammatory effects.
ATPergic signalling during seizures and epilepsy.
Henshall et al., Dublin, Ireland. In Neuropharmacology, Dec 2015
The ATP-gated purinergic receptor family is expressed throughout the brain and is functional on neurons and glial cells.
Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival.
Tavazoie et al., New York City, United States. In Nat Cell Biol, Jul 2015
PANX1-mediated ATP release acts as an autocrine suppressor of deformation-induced apoptosis through P2Y-purinergic receptors.
Two disparate ligand-binding sites in the human P2Y1 receptor.
Wu et al., Shanghai, China. In Nature, May 2015
In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target.
A functional landscape of resistance to ALK inhibition in lung cancer.
Garraway et al., Boston, United States. In Cancer Cell, Apr 2015
Among the latter were members of the P2Y purinergic receptor family of G-protein-coupled receptors (P2Y1, P2Y2, and P2Y6).
P2X and P2Y receptor signaling in red blood cells.
Sluyter, Wollongong, Australia. In Front Mol Biosci, 2014
P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology.
Nucleotide signalling during inflammation.
Eltzschig et al., Freiburg, Germany. In Nature, 2014
Metabotropic P2Y receptors are G-protein-coupled, whereas ionotropic P2X receptors are ATP-gated ion channels.
Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
Zhao et al., Shanghai, China. In Nature, 2014
P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides.
A platelet target for venous thrombosis? P2Y1 deletion or antagonism protects mice from vena cava thrombosis.
Schumacher et al., United States. In J Thromb Thrombolysis, 2012
The current study demonstrates that P2Y1 deletion or antagonism significantly reduced venous thrombosis in mice, suggesting that P2Y1 receptors play a role in the pathogenesis of venous thrombosis
Purinergic signaling promotes proliferation of adult mouse subventricular zone cells.
Okano et al., Tokyo, Japan. In J Neurosci, 2012
Purinergic signaling promotes the proliferation of rapidly dividing cells and transit-amplifying cells in the subventricular zone niche through the P2Y1 receptor.
Purinergic neuromuscular transmission is absent in the colon of P2Y(1) knocked out mice.
Jiménez et al., Barcelona, Spain. In J Physiol, 2012
In P2Y(1)(-/-) mice, EFS responses were completely blocked by L-NNA.
P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit.
Ward et al., Reno, United States. In J Physiol, 2012
Purinergic responses were abolished in P2ry1(-/-) mice.
Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation.
Straub et al., Tübingen, Germany. In Plos One, 2011
Combined blockade of P2Y12, P2Y1 and PI3-kinase p110beta fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation.
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