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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Purinergic receptor P2X, ligand-gated ion channel, 7

P2X7, P2X7 receptor, P2X(7)
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: V1a, CAN, PrP, P2Y, ACID
Papers using P2X7 antibodies
Regulated ATP release from astrocytes through lysosome exocytosis
Supplier
Orriss Isabel R. et al., In Frontiers in Endocrinology, 2006
... The P2X7 receptor antagonists were purchased from Tocris Bioscience (Bristol, UK) ...
Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms*
Supplier
Wilson Heather L. et al., In The Journal of Biological Chemistry, 2000
... The selective P2X7 receptor antagonist 15d (36) (A438079 hydrochloride; Tocris Bioscience) was used at ...
Papers on P2X7
miR-9 Mediates CALHM1-Activated ATP-P2X7R Signal in Painful Diabetic Neuropathy Rats.
New
Hu et al., Hengyang, China. In Mol Neurobiol, Feb 2016
The concentration of calcium and ATP as well as the expression of P2X7 receptor in glias was also increased in PDN rats.
P2X7 receptor antagonism reduces severity of spontaneous seizures in a chronic model of temporal lobe epilepsy.
New
Dedeurwaerdere et al., Antwerp, Belgium. In Neuropharmacology, Feb 2016
Brain inflammation gained support as potential target for developing new therapies, especially the P2X7 receptor (P2X7R), involved in processing of IL-1β, might be an interesting candidate.
Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide.
New
Gulbransen et al., East Lansing, United States. In Cell Mol Gastroenterol Hepatol, Feb 2016
Purines generated during inflammation drive enteric neuron death by activating neuronal P2X7 purine receptors (P2X7R), triggering ATP release via neuronal pannexin-1 channels that subsequently recruits intracellular calcium ([Ca(2+)]i) responses in the surrounding enteric glia.
Medicinal chemistry of adenosine, P2Y and P2X receptors.
Review
New
Müller et al., Bethesda, United States. In Neuropharmacology, Jan 2016
Some of these compounds, including A1 and A3 AR agonists, P2Y1R and P2Y12R antagonists, and P2X3, P2X4 and P2X7 antagonists, are potentially of clinical use in treatment of disorders of the nervous system, such as chronic pain, neurodegeneration and brain injury.
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation.
New
Alves et al., Rio de Janeiro, Brazil. In Plos One, Dec 2015
This data suggest the presence of P2X1, P2X2 and P2X7.
Pyroptosis: Caspase-11 Unlocks the Gates of Death.
New
Impact
Martinon et al., Lausanne, Switzerland. In Immunity, Dec 2015
In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
New
Impact
Núñez et al., Ann Arbor, United States. In Immunity, Dec 2015
We found that cytosolic LPS stimulation induced caspase-11-dependent cleavage of the pannexin-1 channel followed up by ATP release, which in turn activated the purinergic P2X7 receptor to mediate cytotoxicity.
Purinergic signalling in brain ischemia.
Review
New
Pugliese et al., Florence, Italy. In Neuropharmacology, Dec 2015
Among P2X receptors most evidence indicate that P2X7 receptor contribute to the damage induced by the ischemic insult due to intracellular Ca(2+) loading in central cells and facilitation of glutamate release.
ATPergic signalling during seizures and epilepsy.
Review
New
Henshall et al., Dublin, Ireland. In Neuropharmacology, Dec 2015
To date, work showing the functional contribution of P2 receptors has been mainly performed in animal models of acute seizures, in particular, by targeting the ionotropic P2X7 receptor subtype.
Purinergic receptors in psychiatric disorders.
Review
New
Krügel, Leipzig, Germany. In Neuropharmacology, Nov 2015
Among the P2 receptor family, in particular P2X7 and P2Y1 receptors were related to disturbances in major depression and schizophrenia, respectively.
Purinergic contribution to amyotrophic lateral sclerosis.
Review
New
Amadio et al., Roma, Italy. In Neuropharmacology, Nov 2015
In particular, here we recapitulate very early results about P2X4, P2X7 and P2Y6 receptor expression in tissues from ALS animal and cell models and patients, and more recent achievements about purinergic signalling mainly performed in vitro in microglia and lately in astrocytes and motoneurons.
Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release.
New
Impact
Arditi et al., Los Angeles, United States. In Immunity, May 2015
LPS triggered the AM purinergic receptor P2X7(R) to induce Ca(2+) influx and ATP depletion, which led to necrosis.
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
Impact
Ambati et al., Lexington, United States. In Science, 2014
Alu (an endogenous retroelement that also requires reverse transcriptase for its life cycle)-derived RNAs activate P2X7 and the NLRP3 inflammasome to cause cell death of the retinal pigment epithelium in geographic atrophy, a type of age-related macular degeneration.
ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism.
Impact
Grassi et al., Bellinzona, Switzerland. In Immunity, 2014
Here we found that the ATP-gated ionotropic P2X7 receptor controls Tfh cell numbers in PPs.
The extrapulmonary dissemination of tuberculosis: A meta-analysis.
Shandera et al., Atlanta, United States. In Int J Mycobacteriol, 2014
CONCLUSION: Young age, female gender, and the macrophage purinergic receptor protein P2X7 were major factors associated with extrapulmonary dissemination of tuberculosis.
Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death.
GeneRIF
Nagasawa et al., Kyoto, Japan. In J Neurochem, 2012
Mechanism underlying ATP-induced neuronal death demonstrates that ATP activates P2X7Rs and that divalent calcium ion (Ca2+) entry via P2X7R-associated-channels, but not -pores, induces mitochondrial dysfunction.
NAD induces astrocyte calcium flux and cell death by ART2 and P2X7 pathway.
GeneRIF
Zhu et al., Hangzhou, China. In Am J Pathol, 2012
NAD induces calcium elevation and astrocyte death by an ART2 and P2X7-mediated mechanism.
Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function.
GeneRIF
Denlinger et al., Madison, United States. In J Allergy Clin Immunol, 2012
P2X(7) functional capacity is associated with asthma risk or disease severity, and these relationships appear to be age related.
The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis.
GeneRIF
Portales-Pérez et al., Mexico. In Cell Immunol, 2012
found no significant association between the SNPs studied and systemic lupus erythematosus or rheumatoid arthritis
The P2X7 receptor is a key modulator of aerobic glycolysis.
GeneRIF
Di Virgilio et al., Ferrara, Italy. In Cell Death Dis, 2011
P2X7R expression allows better adaptability to unfavorable ambient conditions via upregulation of glycolytic enzymes and by increasing intracellular glycogen stores.
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