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Purinergic receptor P2X, ligand-gated ion channel, 6

P2X6, P2X6 receptor, P2XM
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009] (from NCBI)
Papers on P2X6
ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.
GeneRIF
Illes et al., Aachen, Germany. In J Biol Chem, 2012
one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors
Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.
GeneRIF
Toyama et al., Tokyo, Japan. In Pain, 2011
The P2X6 receptor subunit is widely expressed in neuropils in the whole gray matter except for the dorsal superficial layer of the dorsal horn.
Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors.
GeneRIF
Ulrich et al., São Paulo, Brazil. In J Mol Neurosci, 2011
Results suggest a direct relationship between purinergic P2X2/6 receptor expression and induction of neuronal differentiation in mitogen-free cultured rat neurospheres.
Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.
GeneRIF
Xiang et al., Shanghai, China. In Histochem Cell Biol, 2010
The P2X(6) receptors are mainly expressed on intrinsic sensory neurons and that ATP, via P2X(6) receptors probably in heteromeric combination with P2X(2) receptors, may be involved in regulating the physiological functions of these neurons.
P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus.
GeneRIF
Xiang et al., Shanghai, China. In Neurosci Lett, 2009
This study provides the first evidence that P2X8 receptors are expressed on LHRH-containing neurons.
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