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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Purinergic receptor P2X, ligand-gated ion channel 4

P2X4
ATP-activated ionotropic receptor; involved in synaptic transmission in the central nervous system [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: P2X7, P2X2, P2X3, P2Y, CAN
Papers on P2X4
Sex differences in pain: a tale of two immune cells.
New
Salter et al., Toronto, Canada. In Pain, Feb 2016
After peripheral nerve injury, microglia in the spinal cord proliferate and increase cell-surface expression of the purinergic receptor P2X4.
Treatment with a carbon monoxide-releasing molecule (CORM-2) inhibits neuropathic pain and enhances opioid effectiveness in rats.
New
Mika et al., Kraków, Poland. In Pharmacol Rep, Feb 2016
BACKGROUND: Experiments were conducted to evaluate the contribution of P2X4 receptors to the modulation of neuropathy and their ability to amplify opioid effectiveness.
P2X ion channel receptors and inflammation.
New
Burnstock, Melbourne, Australia. In Purinergic Signal, Feb 2016
The P2X7 receptor in particular appears to be an essential immunomodulatory receptor, although P2X1 and P2X4 receptors also appear to be involved.
Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
New
Ni et al., Daqing, China. In Mol Med Report, Jan 2016
P2X4 receptor (P2X4R) is the most widely expressed subtype of the P2XRs in the purinergic receptor family.
Fatigue sensation and gene expression in trained cyclists following a 40 km time trial in the heat.
New
White et al., Salt Lake City, United States. In Eur J Appl Physiol, Jan 2016
Both trials resulted in significant post-exercise decreases in metabolite detecting receptors ASIC3, P2X4, TRPV1, and TRPV4; increases in adrenergic receptors α2a, α2c, and β1; decreases in adrenergic β2, the immune receptor TLR4, and dopamine (DRD4); and increases in serotonin (HTR1D) and IL-10 (p < 0.05).
Medicinal chemistry of adenosine, P2Y and P2X receptors.
Review
New
Müller et al., Bethesda, United States. In Neuropharmacology, Jan 2016
Some of these compounds, including A1 and A3 AR agonists, P2Y1R and P2Y12R antagonists, and P2X3, P2X4 and P2X7 antagonists, are potentially of clinical use in treatment of disorders of the nervous system, such as chronic pain, neurodegeneration and brain injury.
Molecular Structure and Regulation of P2X Receptors with a Special Emphasis on the Role of P2X2 in the Auditory System.
Review
New
Liu et al., Miami, United States. In J Cell Physiol, Jan 2016
Within the past few years, the characterization of crystal structures of the zebrafish P2X4 receptor in its closed and open states has provided critical insights into the mechanisms of ligand binding and channel activation.
ATPergic signalling during seizures and epilepsy.
Review
New
Henshall et al., Dublin, Ireland. In Neuropharmacology, Dec 2015
The ATP-gated purinergic receptor family is expressed throughout the brain and is functional on neurons and glial cells.
Purinergic contribution to amyotrophic lateral sclerosis.
Review
New
Amadio et al., Roma, Italy. In Neuropharmacology, Nov 2015
In particular, here we recapitulate very early results about P2X4, P2X7 and P2Y6 receptor expression in tissues from ALS animal and cell models and patients, and more recent achievements about purinergic signalling mainly performed in vitro in microglia and lately in astrocytes and motoneurons.
Nucleotides in neuroregeneration and neuroprotection.
Review
New
Perez-Sen et al., Madrid, Spain. In Neuropharmacology, Oct 2015
In this regard, current strategies of acute transplantation of ependymal stem/progenitor cells after spinal cord injury restore altered expression of P2X4 and P2X7 receptors and improve functional locomotor recovery.
P2X4R+ microglia drive neuropathic pain.
GeneRIF
Salter et al., Toronto, Canada. In Nat Neurosci, 2012
Neuropathic pain may be driven by P2X4R+ microglia.
Molecular mechanism of ATP binding and ion channel activation in P2X receptors.
Impact
GeneRIF
Gouaux et al., Portland, United States. In Nature, 2012
crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of the apo receptor
Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK.
GeneRIF
Khakh et al., Los Angeles, United States. In J Biol Chem, 2012
lateral mobility is P2X subunit- and cell-specific, increased in an ATP activation and calcium-dependent manner, and enhanced in activated microglia by the p38 MAPK pathway that selectively regulates slowly mobile receptors
Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages.
GeneRIF
Kojima et al., Noda, Japan. In Biochem Biophys Res Commun, 2012
co-expression of P2X4 receptor with P2X7 receptor enhances P2X7-mediated inflammation through both facilitation of release of cytokines and suppression of autophagy.
P2X4 receptors influence inflammasome activation after spinal cord injury.
GeneRIF
Lacroix et al., Miami, United States. In J Neurosci, 2012
P2X4 knock-out mice show impaired inflammasome signaling following spinal cord injury, resulting in decreased levels of IL-1beta and reduced infiltration of neutrophils and monocyte-derived M1 macrophages.
Activation and regulation of purinergic P2X receptor channels.
Review
Impact
Stojilkovic et al., Bethesda, United States. In Pharmacol Rev, 2011
The transmembrane domains account not only for the formation of the channel pore but also for the binding of ivermectin (a specific P2X4R allosteric regulator) and alcohols.
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.
Impact
GeneRIF
Ando et al., Tokyo, Japan. In Nat Med, 2006
endothelial P2X4 channels are crucial to flow-sensitive mechanisms that regulate blood pressure and vascular remodeling
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.
Impact
GeneRIF
Inoue et al., Tokyo, Japan. In Nature, 2003
pharmacological blockade of spinal P2X4 receptors (P2X4Rs), a subtype of ionotropic ATP receptor, reversed tactile allodynia caused by peripheral nerve injury without affecting acute pain behaviours in naive animals
Molecular physiology of P2X receptors.
Review
Impact
North, Sheffield, United Kingdom. In Physiol Rev, 2002
Homomeric P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7 channels and heteromeric P2X2/3 and P2X1/5 channels have been most fully characterized following heterologous expression.
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