P2X ion channel receptors and inflammation.
Melbourne, Australia. In Purinergic Signal, Feb 2016
The P2X7 receptor in particular appears to be an essential immunomodulatory receptor, although P2X1 and P2X4 receptors also appear to be involved.
Medicinal chemistry of adenosine, P2Y and P2X receptors.
Bethesda, United States. In Neuropharmacology, Jan 2016
Some of these compounds, including A1 and A3 AR agonists, P2Y1R and P2Y12R antagonists, and P2X3, P2X4 and P2X7 antagonists, are potentially of clinical use in treatment of disorders of the nervous system, such as chronic pain, neurodegeneration and brain injury.
Purinergic contribution to amyotrophic lateral sclerosis.
Roma, Italy. In Neuropharmacology, Nov 2015
In particular, here we recapitulate very early results about P2X4, P2X7 and P2Y6 receptor expression in tissues from ALS animal and cell models and patients, and more recent achievements about purinergic signalling mainly performed in vitro in microglia and lately in astrocytes and motoneurons.
Nucleotides in neuroregeneration and neuroprotection.
Madrid, Spain. In Neuropharmacology, Oct 2015
In this regard, current strategies of acute transplantation of ependymal stem/progenitor cells after spinal cord injury restore altered expression of P2X4 and P2X7 receptors and improve functional locomotor recovery.
Molecular physiology of P2X receptors.
Sheffield, United Kingdom. In Physiol Rev, 2002
Homomeric P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7 channels and heteromeric P2X2/3 and P2X1/5 channels have been most fully characterized following heterologous expression.