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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Purinergic receptor P2X, ligand-gated ion channel, 3

P2X3
ligand gated, cation-selective ion channel that is a receptor for ATP [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: P2X2, CAN, P2X4, V1a, P2X7
Papers on P2X3
Mechanisms mediating Nitroglycerin-induced Delayed Onset Hyperalgesia in the Rat.
New
Green et al., San Francisco, United States. In Neuroscience, Feb 2016
Furthermore, A-317491, a P2X3 antagonist, which inhibits endothelial cell-dependent hyperalgesia, also prevents GTN and mast cell-mediated hyperalgesia.
lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia.
New
Liang et al., Nanchang, China. In Mol Neurobiol, Feb 2016
The aim of this study was to investigate the effects of lncRNA NONRATT021972 small interference RNA (siRNA) on DNP mediated by the P2X3 receptor in dorsal root ganglia (DRG).
Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy.
New
Chen et al., Chongqing, China. In Neurochem Res, Feb 2016
UNASSIGNED: Purinergic P2X3 receptors (P2X3Rs) play extensive roles in nerve cells in the central nervous system, particularly in hyperexcitability and calcium (Ca(2+)) influx.
Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) Can Ameliorate Cyclophosphamide-induced Ongoing Bladder Overactivity and Acidic Adenosine Triphosphate Solution-induced Hyperactivity on Rats Prestimulated Bladder.
New
Chiang et al., Kao-hsiung, Taiwan. In J Ethnopharmacol, Jan 2016
The CYP group had significant protein overexpression in mucosal M2, M3, P2X2, and P2X3 receptors as well as detrusor M2 and M3 receptors.
Medicinal chemistry of adenosine, P2Y and P2X receptors.
Review
New
Müller et al., Bethesda, United States. In Neuropharmacology, Jan 2016
Some of these compounds, including A1 and A3 AR agonists, P2Y1R and P2Y12R antagonists, and P2X3, P2X4 and P2X7 antagonists, are potentially of clinical use in treatment of disorders of the nervous system, such as chronic pain, neurodegeneration and brain injury.
Purinergic signalling during development and ageing.
Review
New
Dale et al., London, United Kingdom. In Purinergic Signal, Sep 2015
By contrast, in the periphery, increases in expression of P2X3 and P2X4 receptors are seen in bladder and pancreas.
Purinergic Signalling in the Reproductive System.
Review
New
Gorodeski, Cleveland, United States. In Auton Neurosci, Sep 2015
Analysis of functional expression of purinoceptors suggests that P2Y2 receptors are involved in the regulation of luminal fluid secretion in vivo; P2X1 and P2X2 in the regulation of smooth muscle cell contraction of blood vessels and tubular organs; P2X2 in the regulation of sperm cell maturation; P2X3 in activation of sensory nerve fibers involved in reflex activities and pain; P2X4 in the regulation of tight junctional resistance and epithelial transport in female reproductive tract epithelia, and in the regulation of luminal acidification in the epididymis, vas deferens and probably the vagina and ectocervix; P2Y1 and P2Y2 in the regulation of cell proliferation; P2X5 and P2X7A in the regulation of epithelial cell terminal differentiation and apoptosis; and A1 receptors in the regulation of sperm cell capacitation.
Purinergic signalling in the urinary bladder.
Review
New
Andersson, Århus, Denmark. In Auton Neurosci, Sep 2015
After release, ATP acts on P2X3 and P2X2/3 receptors on suburothelial sensory nerves to initiate the voiding reflex and to mediate the sensation of bladder filling and urgency.
P2X3 receptors and sensitization of autonomic reflexes.
Review
New
Paton et al., San Mateo, United States. In Auton Neurosci, Sep 2015
A great deal of basic and applied physiology and pharmacology in sensory and autonomic neuroscience has teased apart mechanisms that drive normal perception of mechanical, thermal and chemical signals and convey them to CNS, the distinction of fiber types and receptors and channels that mediate them, and how they may become dysfunctional or maladaptive in disease.
P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.
New
Impact
Smith et al., Manchester, United Kingdom. In Lancet, Apr 2015
BACKGROUND: Preclinical studies suggest that P2X3 receptors are expressed by airway vagal afferent nerves and contribute to the hypersensitisation of sensory neurons.
Urothelial signaling.
Review
Impact
Andersson et al., Pittsburgh, United States. In Physiol Rev, 2013
They express a variety of receptors and ion channels, including P2X3 purinergic receptors, nicotinic and muscarinic receptors, and TRP channels, which all have been implicated in urothelial-neuronal interactions, and involved in signals that via components in the underlying lamina propria, such as interstitial cells, can be amplified and conveyed to nerves, detrusor muscle cells, and ultimately the central nervous system.
Estrogen modulation of visceral nociceptors.
Chaban, Los Angeles, United States. In Curr Trends Neurol, 2012
Within the context of our hypothesis visceral nociception and nociceptor sensitization appear to be regulated by purinergic P2X3 and vanilloid TRPV1 receptors and 17β-estradiol modulates DRG neuron response to ATP (P2X agonist) and capsaicin (TRPV1 agonist) suggesting that visceral afferent nociceptors are modulated by estrogen in the DRG.
Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats.
GeneRIF
McGaraughty et al., United States. In J Neurosci Res, 2012
These data suggest that P2X3 and/or P2X2/3 receptors have a broad contribution to somatosensory/nociceptive transmission in rats with a chronic inflammatory injury
Effects of nucleotide analogs at the P2X3 receptor and its mutants identify the agonist binding pouch.
GeneRIF
Illes et al., Leipzig, Germany. In Mol Pharmacol, 2012
The effects of single alanine substitutions of amino acid residues in the supposed ATP binding site of the human P2X3 receptor on the agonistic effect of nucleotide analogs.
Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-α and estrogen receptor-β knockout mice.
GeneRIF
Chaban et al., Los Angeles, United States. In Neuroreport, 2012
interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.
ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.
GeneRIF
Illes et al., Aachen, Germany. In J Biol Chem, 2012
one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors
P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons.
GeneRIF
Huang et al., Galveston, United States. In Mol Pain, 2011
P2X7Rs in satellite glial cell exert inhibitory control on the P2X3R expression and function in sensory neurons of immature rats.
ATP signaling is crucial for communication from taste buds to gustatory nerves.
Impact
Kinnamon et al., Aurora, United States. In Science, 2006
Genetic elimination of ionotropic purinergic receptors (P2X2 and P2X3) eliminates taste responses in the taste nerves, although the nerves remain responsive to touch, temperature, and menthol.
Molecular physiology of P2X receptors.
Review
Impact
North, Sheffield, United Kingdom. In Physiol Rev, 2002
Homomeric P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7 channels and heteromeric P2X2/3 and P2X1/5 channels have been most fully characterized following heterologous expression.
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors.
Impact
Wood et al., London, United Kingdom. In Nature, 2000
The ATP receptor P2X3 is selectively expressed by nociceptors and is one of seven ATP-gated, cation-selective ion channels.
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