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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Purinergic receptor P2X, ligand-gated ion channel, 2

P2X2
subunits assemble into ATP-gated ion channels involved in neuritogenesis and cell survival [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: P2X3, P2X4, P2X7, ACID, CAN
Papers on P2X2
Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin and ATP in Sprague Dawley rats.
New
Taylor-Clark et al., United States. In J Appl Physiol, Jan 2016
Here, we have investigated the effect of capsaicin (TRPV1 agonist), AITC (TRPA1 agonist) and ATP (P2X2/3 agonist) on bronchopulmonary sensory activity and cardiovascular responses of conscious Sprague Dawley (SD) rats.
Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) Can Ameliorate Cyclophosphamide-induced Ongoing Bladder Overactivity and Acidic Adenosine Triphosphate Solution-induced Hyperactivity on Rats Prestimulated Bladder.
New
Chiang et al., Kao-hsiung, Taiwan. In J Ethnopharmacol, Jan 2016
The CYP group had significant protein overexpression in mucosal M2, M3, P2X2, and P2X3 receptors as well as detrusor M2 and M3 receptors.
Dura-evoked neck muscle activity involves purinergic and N-methyl-D-aspartate receptor mechanisms.
New
Sessle et al., Hiroshima, Japan. In Neuroreport, Jan 2016
The primary aim of this study was to determine whether purinergic receptor mechanisms may be involved in these EMG effects, and whether N-methyl-D-aspartate (NMDA) receptor processes modulate the purinergic mechanisms.
Molecular Structure and Regulation of P2X Receptors with a Special Emphasis on the Role of P2X2 in the Auditory System.
Review
New
Liu et al., Miami, United States. In J Cell Physiol, Jan 2016
Moreover, an emphasis on the P2X2 receptors has been placed in respect to its role in the auditory system.
Colchicine-Update on mechanisms of action and therapeutic uses.
Review
New
Kraus et al., Singapore, Singapore. In Semin Arthritis Rheum, Dec 2015
Newly described mechanisms include various inhibitory effects on macrophages including the inhibition of the NACHT-LRRPYD-containing protein 3 (NALP3) inflammasome, inhibition of pore formation activated by purinergic receptors P2X7 and P2X2, and stimulation of dendritic cell maturation and antigen presentation.
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation.
New
Alves et al., Rio de Janeiro, Brazil. In Plos One, Dec 2015
This data suggest the presence of P2X1, P2X2 and P2X7.
Purinergic receptors in embryonic and adult neurogenesis.
Review
New
Ulrich et al., São Paulo, Brazil. In Neuropharmacology, Nov 2015
While several P2 receptor subtypes were shown to be expressed during in vitro and in vivo neurogenesis, specific functions have been proposed for P2Y1, P2Y2 metabotropic as well as P2X2 ionotropic receptors to promote neurogenesis.
Purinergic Signalling in the Reproductive System.
Review
New
Gorodeski, Cleveland, United States. In Auton Neurosci, Sep 2015
Analysis of functional expression of purinoceptors suggests that P2Y2 receptors are involved in the regulation of luminal fluid secretion in vivo; P2X1 and P2X2 in the regulation of smooth muscle cell contraction of blood vessels and tubular organs; P2X2 in the regulation of sperm cell maturation; P2X3 in activation of sensory nerve fibers involved in reflex activities and pain; P2X4 in the regulation of tight junctional resistance and epithelial transport in female reproductive tract epithelia, and in the regulation of luminal acidification in the epididymis, vas deferens and probably the vagina and ectocervix; P2Y1 and P2Y2 in the regulation of cell proliferation; P2X5 and P2X7A in the regulation of epithelial cell terminal differentiation and apoptosis; and A1 receptors in the regulation of sperm cell capacitation.
Purinergic signalling in the urinary bladder.
Review
New
Andersson, Århus, Denmark. In Auton Neurosci, Sep 2015
After release, ATP acts on P2X3 and P2X2/3 receptors on suburothelial sensory nerves to initiate the voiding reflex and to mediate the sensation of bladder filling and urgency.
Astrocyte-derived ATP modulates depressive-like behaviors.
Impact
Gao et al., Guangzhou, China. In Nat Med, 2013
Moreover, we found that P2X2 receptors in the medial prefrontal cortex mediated the antidepressant-like effects of ATP.
Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats.
GeneRIF
McGaraughty et al., United States. In J Neurosci Res, 2012
These data suggest that P2X3 and/or P2X2/3 receptors have a broad contribution to somatosensory/nociceptive transmission in rats with a chronic inflammatory injury
High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism.
GeneRIF
Hume et al., Ann Arbor, United States. In J Biol Chem, 2012
High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism
ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.
GeneRIF
Illes et al., Aachen, Germany. In J Biol Chem, 2012
one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors
Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference.
GeneRIF
Ulrich et al., São Paulo, Brazil. In Int J Dev Neurosci, 2012
Purinergic signaling is important for cell fate determination during neural differentiation, with P2X2 and P2X7 receptors promoting neurogenesis and gliogenesis, respectively.
P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis.
GeneRIF
Lemos et al., Worcester, United States. In J Neuroendocrinol, 2012
results show that sufficient endogenous ATP is released by bursts of action potentials to act at P2X2 receptors to modulate neuropeptide release.
Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels.
Araki et al., Shenyang, China. In Low Urin Tract Symptoms, 2010
TRPV1, TRPM8, TRPA1, P2X2/3, etc.) have been identified at bladder afferent terminals and have implicated in the generation and modulation of afferent signals, which are elcited by a wide range of bladder stimulations including physiological bladder filling, noxious distension, cold, chemical irritation and inflammation.
ATP signaling is crucial for communication from taste buds to gustatory nerves.
Impact
Kinnamon et al., Aurora, United States. In Science, 2006
Genetic elimination of ionotropic purinergic receptors (P2X2 and P2X3) eliminates taste responses in the taste nerves, although the nerves remain responsive to touch, temperature, and menthol.
Molecular physiology of P2X receptors.
Review
Impact
North, Sheffield, United Kingdom. In Physiol Rev, 2002
Homomeric P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7 channels and heteromeric P2X2/3 and P2X1/5 channels have been most fully characterized following heterologous expression.
State-dependent cross-inhibition between transmitter-gated cation channels.
Impact
Lester et al., Pasadena, United States. In Nature, 2000
Here we show that structurally distinct alpha3beta4 nicotinic and P2X2 channels influence each other when co-activated.
Pharmacology of cloned P2X receptors.
Review
Impact
Surprenant et al., Sheffield, United Kingdom. In Annu Rev Pharmacol Toxicol, 1999
Six homomeric (P2X1, P2X2, P2X3, P2X4, P2X5, P2X7) and three heteromeric (P2X2/P2X3, P2X4/P2X6, P2X1/P2X5) P2X receptor channels have been characterized in heterologous expression systems.
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