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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Peroxiredoxin 6

p29, DKK3
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DKK1, HAD, ACID, SFRP1, CAN
Papers using p29 antibodies
Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3
Supplier
Furukawa Takahisa et al., In Journal of Biomedicine and Biotechnology, 2011
... BAC-Dkk3-EGFP Transgenic Mouse ...
Papers on p29
Two novel mutations affecting the same splice site of PKD1 correlate with different phenotypes in ADPKD.
New
Zou et al., Chongqing, China. In Ren Fail, Jun 2014
To explain the phenomenon, we analyzed the genic and allelic background of the patients, as well as the genetic modifiers, DKK3 and HNF-1β as suggested.
Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.
New
Li et al., Wuhan, China. In Cardiovasc Res, May 2014
AIMS: Dickkopf-3 (DKK3), a secreted protein in the Dickkopf family, is expressed in various tissues, including the heart, and has been shown to play an important role in tissue development.
Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.
New
Ushijima et al., Tokyo, Japan. In Gastric Cancer, Mar 2014
RESULTS: The WNT pathway was activated by mutations of CTNNB1 in 2 GCs and potentially by aberrant methylation of its negative regulators, such as DKK3, NKD1, and SFRP1, in 49 GCs.
Association between polymorphisms in sclerostin, dickkopfs and secreted frizzled-related protein genes and bone mineral density in postmenopausal Korean women.
New
Kim et al., South Korea. In Gynecol Obstet Invest, Dec 2013
METHODS: The SOST, Wnt inhibitory factor 1 (WIF1), sFRP1,sFRP2,sFRP3, sFRP4, sFRP5, DKK1, DKK2 and DKK3 polymorphisms were analyzed in 399 postmenopausal Korean women.
Proteomic analysis of human osteoarthritis synovial fluid.
New
Pandey et al., Pune, India. In Clin Proteomics, Dec 2013
We also confirmed the expression of ANPEP, dickkopf WNT signaling pathway inhibitor 3 (DKK3) and osteoglycin (OGN) by multiple reaction monitoring (MRM) analysis of osteoarthritis synovial fluid samples.
Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.
Impact
Prockop et al., Temple, United States. In Cell Stem Cell, 2013
Also, activated hMSCs secreted DKK3 to suppress MDA cell cycling, leading to a decrease in β-catenin and cyclin D1/D3 and an increase in p21.
Deregulated Cdk5 activity is involved in inducing Alzheimer's disease.
Review
Pant et al., Bethesda, United States. In Arch Med Res, 2012
Upon stress, p35 and p39 are cleaved by calpain resulting in truncated products as p25 and p29.
Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer.
GeneRIF
Holcombe et al., Orange, United States. In Gynecol Oncol, 2012
Dkk3 gene expression is frequently downregulated in endometrial cancer, and is associated with poor prognostic clinicopathologic markers. Results identify a role for Dkk3 as a tumor suppressor in EC, affecting both proliferation and invasiveness.
Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth.
GeneRIF
Brophy et al., Edinburgh, United Kingdom. In J Neurosci, 2012
Cajal band appositions contain a dystroglycan complex that includes periaxin and dystrophin-related protein (Drp)2.
Phox activity of differentiated PLB-985 cells is enhanced, in an agonist specific manner, by the PLA2 activity of Prdx6-PLA2.
GeneRIF
Ambruso et al., Denver, United States. In Eur J Immunol, 2012
(2) activity of Prdx6-PLA(2) in intact cells mediates its ability to enhance phox activity in response to fMLF
Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancer.
GeneRIF
Liu et al., Wuhan, China. In World J Gastroenterol, 2012
Dkk-3 overexpression induced apoptosis in human colon cancer possibly through the mitochondrial pathway. Dkk-3 may be involved in the Wnt/beta-catenin signaling pathways in colon cancer.
Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3.
Review
Dahl et al., Maastricht, Netherlands. In Biochim Biophys Acta, 2012
Indeed, research in Wnt biology has recently provided numerous clues, and evidence is accumulating that the secreted Wnt antagonist Dickkopf-related protein 3 (Dkk-3) and its regulators may constitute interesting therapeutic targets in the most important human cancers.
BAC-Dkk3-EGFP transgenic mouse: an in vivo analytical tool for Dkk3 expression.
GeneRIF
Furukawa et al., Suita, Japan. In J Biomed Biotechnol, 2011
The precise expression of the Dkk3 protein was examined by generating transgenic mice that express EGFP integrated into the Dkk3 gene in a bacterial artificial chromosome plasmid.
Musashi1: a stem cell marker no longer in search of a function.
Review
Yin et al., Washington, D.C., United States. In Cell Cycle, 2008
This process was associated with increased secretion of the growth factor, PLF1 and inhibition of the secreted Wnt pathway inhibitor, DKK3.
Regulation of mammalian ciliary beating.
Review
Salathe, Miami, United States. In Annu Rev Physiol, 2006
The cAMP-dependent phosphorylation of PKA's main target, originally described as p29 in Paramecium, seems to increase ciliary beat frequency (CBF) directly.
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Impact
Torres et al., Córdoba, Spain. In J Clin Oncol, 2005
PATIENTS AND METHODS: Methylation-specific polymerase chain reaction was used to analyze methylation of the ADAMTS-1, ADAMTS-5, APAF-1, ASPP-1, CDH1, CDH13, DAPK, DIABLO, DKK-3, LATS-1, LATS-2, NES-1, p14, p15, p16, p57, p73, PARK-2, PTEN, sFRP1/2/4/5, SHP-1, SYK, TMS-1, and WIF-1 genes in samples from 50 consecutive T-ALL patients (19 children and 31 adults).
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.
Review
Saito et al., Tokyo, Japan. In Neurosignals, 2003
p39 is also a short-lived protein and cleaved to the N-terminal truncation form of p29 by calpain.
Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations.
Impact
Heidecker et al., In Science, 1983
The oncogene (Ra-v-ras) encodes a 29,000-dalton (p29) transforming protein.
Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region.
Impact
Pesando et al., In Nature, 1981
The Ia antigens of the mouse are the basis for the genetic control of the immune response.
Purification and structural characterisation of human HLA-linked B-cell antigens.
Impact
Strominger et al., In Nature, 1977
The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34).
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