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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 May 2015.

Interleukin 27

P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, IL-12, IL-17, Interleukin-6, CAN
Papers on P28
An IL-27/Lag3 axis enhances Foxp3(+) regulatory T cell-suppressive function and therapeutic efficacy.
New
Min et al., Cleveland, United States. In Mucosal Immunol, 27 Jun 2015
Tregs stimulated with IL-27 expressed substantially improved suppressive function in vitro and in vivo.
Interleukin 27 -964A > G genetic polymorphism and serum IL-27p28 levels in Chinese patients with papillary thyroid cancer.
New
Ji et al., Nanjing, China. In Tumour Biol, 21 Jun 2015
UNASSIGNED: The aim of this study was to investigate the association between a potentially functional polymorphism (rs153109, -964A > G) in the promoter region of interleukin-27 (IL-27) gene and the risk of papillary thyroid cancer (PTC) in a Chinese population.
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
New
Impact
O'Shea et al., Bethesda, United States. In Immunity, 19 Jun 2015
Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique and overlapping functions.
Association between two single nucleotide polymorphisms of interleukin-27 gene and increased cryptorchidism risk.
New
Zhang et al., Chengdu, China. In Andrologia, 18 Jun 2015
We aimed to investigate the relationship between IL-27 polymorphisms and cryptorchidism susceptibility.
Molecular and Serological Survey of Rickettsiales Bacteria in Wild Sika Deer (Cervus nippon nippon) in Shizuoka Prefecture, Japan: High Prevalence of Anaplasma Species.
New
Ohashi et al., Shizuoka, Japan. In Jpn J Infect Dis, 12 Jun 2015
In contrast, A. phagocytophilum (human type) 16S rDNA, Rickettsia gltA, Ehrlichia p28/omp-1, and Neoehrlichia 16S rDNA could not be amplified.
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP.
Review
New
Ferrini et al., Genova, Italy. In J Leukoc Biol, 30 Apr 2015
The natural inhibitor IL-18BP , whose production is enhanced by IFN-γ and IL-27, further regulates IL-18 activity in the extracellular environment.
Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27.
Review
New
Liu et al., Shijiazhuang, China. In Int Immunopharmacol, 23 Apr 2015
Several distinct findings have been highlighted that in certain conditions, neutralizing IL-27 or its subunit IL-27p28 might be a useful strategy to limit inflammation.
The immunobiology of interleukin-27.
New
Impact
Hunter et al., Saga, Japan. In Annu Rev Immunol, 21 Apr 2015
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response.
Decreased IL-27 Negatively Correlated with Th17 Cells in Non-Small-Cell Lung Cancer Patients.
New
Zheng et al., Nanning, China. In Mediators Inflamm, Dec 2014
The presence of Th17 cells and IL-27 is observed in a variety of inflammatory associated cancers.
Platelet transfusion - the new immunology of an old therapy.
Review
New
Blumberg et al., Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Review
New
Impact
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, Dec 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
Polymorphisms and plasma levels of IL-27: impact on genetic susceptibility and clinical outcome of bladder cancer.
New
Zhang et al., Chengdu, China. In Bmc Cancer, Dec 2014
BACKGROUND: Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties.
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
New
Impact
Ozato et al., Bethesda, United States. In Immunity, Mar 2014
IRF8 induced a cytokine milieu that favored growth and maintenance of Th1 and Th17 cells, by stimulating interleukin-12 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.
Interleukin-12 family cytokines and sarcoidosis.
Review
Herbert et al., Sydney, Australia. In Front Pharmacol, 2013
Many T-cell-associated cytokines have been implicated in the immunopathogenesis of sarcoidosis, but it is becoming apparent that IL-12 cytokine family members including IL-12, IL-23, IL-27, and IL-35 are also involved.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Impact
Quintana et al., Boston, United States. In Nat Immunol, 2013
We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE).
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 suppresses granulocyte-macrophage colony stimulating factor (GM-CSF) expression in human T cells.
Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.
GeneRIF
Kapsenberg et al., Amsterdam, Netherlands. In J Leukoc Biol, 2012
viral dsRNA-activated human dendritic cells produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.
GeneRIF
Chiffoleau et al., Nantes, France. In Transplantation, 2012
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Human TCRγδ+ T cells represent a novel target for IL-27 activity.
GeneRIF
Airoldi et al., Genova, Italy. In Eur J Immunol, 2012
results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion
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