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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

Interleukin 27

P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, IL-12, IL-17, CAN, Interleukin-6
Papers on P28
Multiple Inflammatory Cytokines Converge To Regulate CD8+ T Cell Expansion and Function during Tuberculosis.
New
Behar et al., Worcester, United States. In J Immunol, Feb 2016
In this study, we define three signals regulating CD8(+) T cell responses during tuberculosis by focusing on cytokines known to affect disease outcome: IL-12, type I IFN, and IL-27.
IL-27 attenuates the TGF-β1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts.
New
Zhang et al., Kunming, China. In Life Sci, Feb 2016
Our previous research showed that interleukin-27(IL-27) potentially attenuates BLM-induced pulmonary fibrosis, but the function of IL-27 in lung fibroblasts (LFs) differentiation pulmonary fibrosis is yet to be known.
IL-30 (IL27p28) alleviates sepsis via modulation of cytokine profiles produced by NKT cells.
New
Li et al., Houston, United States. In J Hepatol, Feb 2016
The inhibitory effects of IL-30 on septic inflammation and associated therapeutic effects were determined in wild-type, IL-30 (p28)(-/-), IL10(-/-), and CD1d(-/-) mice.
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
New
Impact
Koyasu et al., Yokohama, Japan. In Nat Immunol, Jan 2016
Both type I and type II interferons and interleukin 27 (IL-27) suppressed ILC2 function in a manner dependent on the transcription factor STAT1. ILC2-mediated lung inflammation was enhanced in the absence of the interferon-γ (IFN-γ) receptor on ILC2 cells in vivo.
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.
New
Impact
Fritz et al., Montréal, Canada. In Nat Immunol, Jan 2016
In addition, interferon-γ (IFN-γ) and interleukin 27 (IL-27) altered ILC2 function dependent on the transcription factor STAT1.
The role of the cytokines IL-27 and IL-35 in cancer.
New
Liao et al., Columbus, United States. In Math Biosci Eng, Jan 2016
CD8+ T cells are activated by IL-27 cytokine and they kill tumor cells.
IL-27-induced modulation of autoimmunity and its therapeutic potential.
Review
New
Moudgil et al., Baltimore, United States. In Autoimmun Rev, Dec 2015
Interleukin-27 (IL-27) is a new member of the IL-12 family.
Determination of Interleukin 27-Producing CD4(+) and CD8(+) T Cells for The Differentiation Between Tuberculous and Malignant Pleural Effusions.
New
Shi et al., Beijing, China. In Sci Rep, Dec 2015
The numbers of IL-27(+) CD4(+) and IL-27(+) CD8(+) T cells have been found to be increased in tuberculous pleural effusion (TPE) as compared with malignant pleural effusion (MPE).
Potential clinical application of interleukin-27 as an antitumor agent.
Review
New
Mizoguchi et al., Tokyo, Japan. In Cancer Sci, Sep 2015
Evidence obtained using a variety of preclinical mouse models indicates that IL-27 possesses potent antitumor activity against various types of tumors through multiple mechanisms without apparent adverse effects.
IL-20 in rheumatoid arthritis.
Review
New
Chang et al., Tainan City, Taiwan. In Drug Discov Today, Sep 2015
Anti-IL-20 antibody has paved the way to clinical trials aimed at blocking the pathogenic actions of IL-20 in rheumatoid arthritis.
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
New
Impact
O'Shea et al., Bethesda, United States. In Immunity, Jun 2015
Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique and overlapping functions.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Review
Vannay et al., Budapest, Hungary. In Mediators Inflamm, 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.
Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines.
Review
Barnaba et al., Roma, Italy. In Adv Exp Med Biol, 2014
Some controversy exists around IL-27 and IFN-α, cytokines possibly released during bacterial or viral infections.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Review
Impact
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
The immunobiology of interleukin-27.
Review
Impact
Hunter et al., Saga, Japan. In Annu Rev Immunol, 2014
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 suppresses granulocyte-macrophage colony stimulating factor (GM-CSF) expression in human T cells.
Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.
GeneRIF
Kapsenberg et al., Amsterdam, Netherlands. In J Leukoc Biol, 2012
viral dsRNA-activated human dendritic cells produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.
GeneRIF
Chiffoleau et al., Nantes, France. In Transplantation, 2012
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Human TCRγδ+ T cells represent a novel target for IL-27 activity.
GeneRIF
Airoldi et al., Genova, Italy. In Eur J Immunol, 2012
results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion
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