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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Oct 2014.

Interleukin 27

P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-12, IL-10, IL-23, CAN, IL-17
Papers on P28
Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3.
New
Ward et al., Mainz, Germany. In J Immunol, 27 Nov 2014
The effects of heterodimeric IL-27 (p28/EBI3) have been implicated in the natural course of sepsis, whereas the molecular mechanisms underlying the regulation of gene expression and release of IL-27 in sepsis are poorly understood.
The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells.
New
Robinson et al., In Immunology, 26 Nov 2014
However, the specific effect of IL-27 during DC differentiation and how that may change the nature of the antigen presenting cell has not been investigated.
Decreased Interleukin-37 Expression in Vogt-Koyanagi-Harada Disease and Upregulation Following Immunosuppressive Treatment.
New
Yang et al., Chongqing, China. In J Interferon Cytokine Res, 24 Nov 2014
VKH patients showed a decreased IL-37 and IL-27 expression and increased IL-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) levels in PBMC culture supernatants.
Amotosalen-HCl-UVA pathogen reduction does not alter poststorage metabolism of soluble CD40 ligand, Ox40 ligand and interkeukin-27, the cytokines that generally associate with serious adverse events.
New
Garraud et al., Saint-Étienne, France. In Vox Sang, 21 Nov 2014
This study examined the influence of photochemical pathogen reduction treatment (PRT) using amotosalen-HCl and UVA light vs. untreated control platelet components, on three factors recently reported to be associated with serious adverse events associated with platelet component (PC) transfusions: sCD40L, IL-27 and sOX40 ligand.
Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge.
New
Lloyd et al., London, United Kingdom. In Allergy, 21 Nov 2014
A novel role for the macrophage derived immunoregulatory cytokine IL-27 was identified in modulating Th2 inflammation following mucosal allergen exposure.
Behçet's syndrome: a critical digest of the 2013-2014 literature.
Review
New
Hamuryudan et al., İstanbul, Turkey. In Clin Exp Rheumatol, 30 Sep 2014
IL-27, 33 and 37 may also play important roles in the pathogenesis.
Therapeutic targets for rheumatoid arthritis: Progress and promises.
Review
New
Rasheed et al., In Autoimmunity, Mar 2014
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
New
Impact
Ozato et al., Bethesda, United States. In Immunity, Mar 2014
IRF8 induced a cytokine milieu that favored growth and maintenance of Th1 and Th17 cells, by stimulating interleukin-12 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.
Emerging cell and cytokine targets in rheumatoid arthritis.
Review
New
Dörner et al., Berlin, Germany. In Nat Rev Rheumatol, Feb 2014
New cytokine-directed therapies target important proinflammatory mediators such as GM-CSF, new members of the IL-1 family, IL-6 and its receptor, IL-17, IL-20, IL-21, IL-23 as well as synovium-specific targets.
gp130: a promising drug target for cancer therapy.
Review
New
Neamati et al., Ann Arbor, United States. In Expert Opin Ther Targets, Nov 2013
INTRODUCTION: Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
New
Impact
Quintana et al., Boston, United States. In Nat Immunol, Oct 2013
We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE).
Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection.
New
Impact
Zuniga et al., San Diego, United States. In Immunity, Oct 2013
We identified IL-27 as a gp130 cytokine that promoted antiviral CD4⁺ T cell accumulation in vivo and that rapidly induced IL-21 ex vivo.
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.
New
Impact
Datta et al., Bethesda, United States. In Nat Immunol, Aug 2013
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
Interleukin-27: balancing protective and pathological immunity.
Review
Impact
Kastelein et al., Philadelphia, United States. In Immunity, 2013
It has been more than 15 years since the identification of individual interleukin-27 (IL-27) and IL-27 receptor components.
Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents.
Review
Grohmann et al., Perugia, Italy. In Biotechnol Genet Eng Rev, 2012
By sharing cytokine and receptor subunits, IL-12 (comprised of p40/p35 subunits), IL-23 (p40/p19), IL-27 (p28/EBI3), and IL-35 (p35/EBI3) represent, as a whole, a highly versatile system participating in controlling the continuum from inflammation to tolerance.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 suppresses granulocyte-macrophage colony stimulating factor (GM-CSF) expression in human T cells.
Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.
GeneRIF
Kapsenberg et al., Amsterdam, Netherlands. In J Leukoc Biol, 2012
viral dsRNA-activated human dendritic cells produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.
GeneRIF
Chiffoleau et al., Nantes, France. In Transplantation, 2012
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Human TCRγδ+ T cells represent a novel target for IL-27 activity.
GeneRIF
Airoldi et al., Genova, Italy. In Eur J Immunol, 2012
results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion
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