Therapeutic targets for rheumatoid arthritis: Progress and promises.
In Autoimmunity, Mar 2014
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
Emerging cell and cytokine targets in rheumatoid arthritis.
Berlin, Germany. In Nat Rev Rheumatol, Feb 2014
New cytokine-directed therapies target important proinflammatory mediators such as GM-CSF, new members of the IL-1 family, IL-6 and its receptor, IL-17, IL-20, IL-21, IL-23 as well as synovium-specific targets.
Role of IL-22 in microbial host defense.
San Francisco, United States. In Curr Top Microbiol Immunol, Dec 2013
Based on their functions, the IL-10 family can be further divided into three subgroups, IL-10 itself, the IL-20 subfamily, and the IFNλ subfamily.
Interleukin-12 family cytokines and sarcoidosis.
Sydney, Australia. In Front Pharmacol, Dec 2013
Many T-cell-associated cytokines have been implicated in the immunopathogenesis of sarcoidosis, but it is becoming apparent that IL-12 cytokine family members including IL-12, IL-23, IL-27, and IL-35 are also involved.