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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Interleukin 27

P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, IL-12, CAN, IL-17, IL-23
Papers on P28
Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections.
New
Wack et al., London, United Kingdom. In J Interferon Cytokine Res, 25 Mar 2015
The underlying mechanisms by which type I IFNs promote susceptibility or severity include direct tissue damage by apoptosis induction or suppression of proliferation in tissue cells, immunopathology due to excessive inflammation, and cell death induced by TRAIL- and Fas-expressing immune cells, as well as immunosuppression through IL-10, IL-27, PD-L1, IL-1Ra, and other regulatory molecules that antagonize the induction or action of IL-1, IL-12, IL-17, IFN-γ, KC, and other effectors of the immune response.
Efficacy and safety of anti-IL-20 monoclonal antibody in patients with rheumatoid arthritis: A randomized phase 2a trial.
New
Cañete et al., Praha, Czech Republic. In Arthritis Rheumatol, 23 Mar 2015
UNASSIGNED: Objective: Interleukin-20 (IL-20) is implicated in the pathogenesis of rheumatoid arthritis (RA).
Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation.
New
Manicassamy et al., Kyoto, Japan. In J Immunol, 20 Mar 2015
This was due to increased production of proinflammatory cytokines and decreased production of anti-inflammatory cytokines such as IL-10 and IL-27 by DCs lacking LRP5/6-β-catenin signaling.
The Yin and Yang aspects of IL-27 in induction of cancer-specific T-cell responses and immunotherapy.
New
Bai et al., Guangzhou, China. In Immunotherapy, 28 Feb 2015
UNASSIGNED: Accumulating evidences from animal studies have indicated that both endogenous and exogenous IL-27, an IL-12 family of cytokine, can increase antitumor T-cell activities and inhibit tumor growth.
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP.
Review
New
Ferrini et al., Genova, Italy. In J Leukoc Biol, Jan 2015
The natural inhibitor IL-18BP , whose production is enhanced by IFN-γ and IL-27, further regulates IL-18 activity in the extracellular environment.
Effects of statins on TH1 modulating cytokines in human subjects.
New
Palka et al., Buffalo, United States. In Peerj, Dec 2014
The goal of our study was to assess the TH1 modulating cytokines IL-12 p40 and IL-18, and their counter regulatory cytokines IL-18 binding protein and IL-27, to determine if their levels are linked to cholesterol levels or other factors.
Cellular cytokine and chemokine responses to parasite antigens and fungus and mite allergens in children co-infected with helminthes and protozoa parasites.
New
Köhler et al., Tübingen, Germany. In J Inflamm (lond), Dec 2014
When PBMC were stimulated in vitro with parasite antigens and allergens, regulatory-type cytokine IL-27 and alarmin-type IL-33 enhanced with poly-parasite infections whilst IL-10 and pro-inflammatory MIP3-α/CCL20 and MIG/CXCL9 were produced in similar amounts in singly or poly-parasitized children.
Interleukin-27 in T Cell Immunity.
Review
New
Yamamoto et al., Tokyo, Japan. In Int J Mol Sci, Dec 2014
IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Review
New
Impact
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, Dec 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
Platelet transfusion - the new immunology of an old therapy.
Review
New
Blumberg et al., Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
New
Impact
Ozato et al., Bethesda, United States. In Immunity, Mar 2014
IRF8 induced a cytokine milieu that favored growth and maintenance of Th1 and Th17 cells, by stimulating interleukin-12 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.
Interleukin-12 family cytokines and sarcoidosis.
Review
Herbert et al., Sydney, Australia. In Front Pharmacol, 2013
Many T-cell-associated cytokines have been implicated in the immunopathogenesis of sarcoidosis, but it is becoming apparent that IL-12 cytokine family members including IL-12, IL-23, IL-27, and IL-35 are also involved.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Impact
Quintana et al., Boston, United States. In Nat Immunol, 2013
We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE).
Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection.
Impact
Zuniga et al., San Diego, United States. In Immunity, 2013
We identified IL-27 as a gp130 cytokine that promoted antiviral CD4⁺ T cell accumulation in vivo and that rapidly induced IL-21 ex vivo.
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.
Impact
Datta et al., Bethesda, United States. In Nat Immunol, 2013
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 suppresses granulocyte-macrophage colony stimulating factor (GM-CSF) expression in human T cells.
Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.
GeneRIF
Kapsenberg et al., Amsterdam, Netherlands. In J Leukoc Biol, 2012
viral dsRNA-activated human dendritic cells produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.
GeneRIF
Chiffoleau et al., Nantes, France. In Transplantation, 2012
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Human TCRγδ+ T cells represent a novel target for IL-27 activity.
GeneRIF
Airoldi et al., Genova, Italy. In Eur J Immunol, 2012
results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion
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