Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney.
Baltimore, United States. In J Am Soc Nephrol, 27 Sep 2015
Unlike CD4(+) and CD8(+) T cells, DN T cells in the steady state expressed high levels of CD69, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inflammatory cytokines; spontaneously proliferated at a very high rate; and suppressed in vitro proliferation of activated CD4(+) T cells.
IL-20 in Rheumatoid arthritis.
Tainan City, Taiwan. In Drug Discov Today, 18 Sep 2015
Anti-IL-20 antibody has paved the way to clinical trials aimed at blocking the pathogenic actions of IL-20 in rheumatoid arthritis.
Platelet transfusion - the new immunology of an old therapy.
Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Budapest, Hungary. In Mediators Inflamm, Dec 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.