Altered transcription of inflammation-related genes in dental pulp of coeliac children.
Roma, Italy. In Int J Paediatr Dent, 06 Nov 2015
AIM: The dental pulp plays a pivotal role in the immune defence against possible entry of pathogens from teeth, and the aim of this work was to investigate quantitative transcription levels of selected genes (IL-9, IL-11, IL-15, IL-18, IL-21, IL-27, MICA, IFN-γ) coding for pro-inflammatory immune innate activities in the pulp of primary teeth from healthy children and children with coeliac disease.
Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis.
Berlin, Germany. In Semin Immunopathol, 05 Nov 2015
Gradients of cytokines and chemokines (CCR2, CXCR2, CXCR3/CXCR5 agonists; TNF/IL-10, IL-1/IFN-I), expression of activation/death markers on immune cells (TNF receptor 1, PD-1, IL-27 receptor) or abundance of enzymes [arginase-1, matrix metalloprotease (MMP)-1, MMP-8, MMP-9] drive genesis and progression of lesions.
Therapeutic potential of interleukin-27 against cancers in preclinical mouse models.
Tokyo, Japan. In Oncoimmunology, 31 Oct 2015
UNASSIGNED: Since we first reported the antitumor efficacy of IL-27 in 2004, accumulating evidence obtained by several groups using a variety of preclinical mouse models indicates that IL-27 possesses potent antitumor activity against various types of tumors through multiple mechanisms depending on the characteristics of individual tumors without apparent adverse effects.
Elevated IL-35 in bone marrow of the patients with acute myeloid leukemia.
Hefei, China. In Hum Immunol, 29 Oct 2015
IL-35 is a recently described cytokine composed of an IL-12 subunit p35 and an IL-27 subunit Epstein-Barr virus induced gene 3 (EBI3), and has an immunosuppressive effect on inflammation through induction of regulatory T cells (Tregs) and suppression of Th1 and Th17.
Platelet transfusion - the new immunology of an old therapy.
Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family.
Budapest, Hungary. In Mediators Inflamm, Dec 2014
In the present review we provide an overview of the common key mediators of organ fibrosis highlighting the role of interleukin-10 (IL-10) cytokine family members (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26), which recently came into focus as tissue remodeling-related inflammatory cytokines.