GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 25 Jan 2016.
P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from
Zhang et al., Kunming, China. In Life Sci, 08 Feb 2016
Our previous research showed that interleukin-27(IL-27) potentially attenuates BLM-induced pulmonary fibrosis, but the function of IL-27 in lung fibroblasts (LFs) differentiation pulmonary fibrosis is yet to be known.
Koyasu et al., Yokohama, Japan. In Nat Immunol, 31 Jan 2016
Both type I and type II interferons and interleukin 27 (IL-27) suppressed ILC2 function in a manner dependent on the transcription factor STAT1. ILC2-mediated lung inflammation was enhanced in the absence of the interferon-γ (IFN-γ) receptor on ILC2 cells in vivo.
Sytwu et al., Taipei, Taiwan. In Int Immunopharmacol, 28 Jan 2016
Furthermore, melatonin enhances splenic interleukin (IL)-10 expression in regulatory T cells by inducing IL-27 expression in the splenic DC; it also suppresses the expression of IFN-γ, IL-17, IL-6, and CCL20 in the CNS and inhibits antigen-specific T cell proliferation.
Erdmann et al., Germany. In Immunology, 23 Jan 2016
UNASSIGNED: The Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin (IL)-12-family structurally related to the subunit p40 of IL-12 and forms a heterodimer either with the p28 subunit to build IL-27 or with p35 to form IL-35. IL-27 is secreted by antigen presenting cells whereas IL-35 appears to be produced mainly by regulatory T cells and regulatory B cells but both cytokines negatively regulate inflammatory immune responses.
Antas et al., Rio de Janeiro, Brazil. In Immunol Lett, 11 Jan 2016
Concentrations of ex vivo monokine levels, such as interleukins (IL)-18, IL-23 and IL-27, were profoundly reduced in the UV in relation to the HD group (p-values of 0.003, 0.009 and < 0.0001, respectively).