Emerging cell and cytokine targets in rheumatoid arthritis.
Berlin, Germany. In Nat Rev Rheumatol, 12 Dec 2013
New cytokine-directed therapies target important proinflammatory mediators such as GM-CSF, new members of the IL-1 family, IL-6 and its receptor, IL-17, IL-20, IL-21, IL-23 as well as synovium-specific targets.
IL-27 in tumor immunity and immunotherapy.
Boston, United States. In Trends Mol Med, Feb 2013
Interleukin (IL)-27 is an IL-12 family cytokine chiefly produced by antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages, and alone or in combination with other cytokines, IL-27 boosts antitumor immunity by contributing to the development of NK cells and CTLs - a central immnunomodulatory effect - and by exerting potent antiangiogenic and antimetastatic activities, a local antitumor effect.