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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Interleukin 27

P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-12, IL-10, IL-23, CAN, Interleukin-6
Papers on P28
Association Between Gene Expression Biomarkers of Immunosuppression and Blood Transfusion in Severely Injured Polytrauma Patients.
New
Oʼdwyer et al., Mary, Turkmenistan. In Ann Surg, 25 Apr 2014
Transfusion was associated with a greater immediate rise in IL-10 (P = 0.003) and IL-27 (P = 0.04) mRNA levels.
Cardiac aging is initiated by matrix metalloproteinase-9 mediated endothelial dysfunction.
New
Jin et al., United States. In Am J Physiol Heart Circ Physiol, 21 Apr 2014
The 15-18 mo WT showed amplified expression of inflammatory genes related to angiogenesis, including C-C chemokine receptor (CCR)7, CCR10, interleukin (IL)-1f8, IL-13, and IL-20 (all p<0.05), and these increases were blunted by MMP-9 deletion (all p<0.05).
Effects of nonlinear resistance and aerobic interval training on cytokines and insulin resistance in sedentary obese men.
New
Ebrahim et al., Tehrān, Iran. In J Strength Cond Res, 21 Apr 2014
The purpose of this study was to compare the effects of nonlinear resistance training (NRT) and aerobic interval training (AIT) on serum interleukin-10 (IL-10), IL-20 and tumor necrosis factor α (TNF-α) levels, insulin resistance index (HOMA-IR) and aerobic capacity in middle-aged obese men.
The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation.
New
Impact
Ozato et al., Bethesda, United States. In Immunity, 20 Mar 2014
IRF8 induced a cytokine milieu that favored growth and maintenance of Th1 and Th17 cells, by stimulating interleukin-12 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.
Mathematical modeling of interleukin-27 induction of anti-tumor T cells response.
New
Friedman et al., Columbus, United States. In Plos One, Dec 2013
Recent experiments in vitro and in vivo have shown that cancer cells transfected with IL-27 activate CD8+ T cells to promote the secretion of anti-tumor cytokines Interleukin-10, although, at the same time, IL-27 inhibits the secretion of Interferon-[Formula: see text] by CD8+ T cells.
Modulation of inflammation by interleukin-27.
Review
New
Ward et al., Ann Arbor, United States. In J Leukoc Biol, Dec 2013
IL-27 is composed of two subunits (p28 and EBI3) and is classified as a member of the IL-12 family of cytokines.
IL-27 Activates Human Trophoblasts to Express IP-10 and IL-6: Implications in the Immunopathophysiology of Preeclampsia.
New
Qi et al., Chongqing, China. In Mediators Inflamm, Dec 2013
To investigate the effects of IL-27 on human trophoblasts and the underlying regulatory signaling mechanisms in preeclampsia.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
New
Impact
Quintana et al., Boston, United States. In Nat Immunol, Oct 2013
We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE).
Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection.
New
Impact
Zuniga et al., San Diego, United States. In Immunity, Oct 2013
We identified IL-27 as a gp130 cytokine that promoted antiviral CD4⁺ T cell accumulation in vivo and that rapidly induced IL-21 ex vivo.
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.
New
Impact
Datta et al., Bethesda, United States. In Nat Immunol, Aug 2013
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
Interleukin-35: the future of hyperimmune-related diseases?
Review
New
Zheng et al., Hangzhou, China. In J Interferon Cytokine Res, Jun 2013
It contains Epstein-Barr virus-induced gene 3 subunit and IL-27 p35 subunit.
IL-27 in tumor immunity and immunotherapy.
Review
New
Saha et al., Boston, United States. In Trends Mol Med, Feb 2013
Interleukin (IL)-27 is an IL-12 family cytokine chiefly produced by antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages, and alone or in combination with other cytokines, IL-27 boosts antitumor immunity by contributing to the development of NK cells and CTLs - a central immnunomodulatory effect - and by exerting potent antiangiogenic and antimetastatic activities, a local antitumor effect.
Interleukin-27: balancing protective and pathological immunity.
Review
Impact
Kastelein et al., Philadelphia, United States. In Immunity, 2013
It has been more than 15 years since the identification of individual interleukin-27 (IL-27) and IL-27 receptor components.
[Toward therapeutic application of IL-10-producing regulatory T cells].
Review
Yamamoto et al., Tokyo, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2012
Although specific surface markers or origin of Tr1 cells have not fully been clarified yet, IL-27 was recently reported to induce IL-10 production in T cells and be an inducer of Tr1 cells.
The need to accessorize: molecular roles of HTLV-1 p30 and HTLV-2 p28 accessory proteins in the viral life cycle.
Review
Green et al., Columbus, United States. In Front Microbiol, 2012
Of these proteins, HTLV-1 p30 and HTLV-2 p28 are encoded by the open reading frame II of the pX region.
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 suppresses granulocyte-macrophage colony stimulating factor (GM-CSF) expression in human T cells.
Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.
GeneRIF
Kapsenberg et al., Amsterdam, Netherlands. In J Leukoc Biol, 2012
viral dsRNA-activated human dendritic cells produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.
GeneRIF
Chiffoleau et al., Nantes, France. In Transplantation, 2012
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Human TCRγδ+ T cells represent a novel target for IL-27 activity.
GeneRIF
Airoldi et al., Genova, Italy. In Eur J Immunol, 2012
results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion
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