GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 27
P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
P28
IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation.
New
Frederick, United States. In J Exp Med, 11 Apr 2013
IL-27 is an anti-HIV cytokine that also modulates monocyte activation.
Interleukin-35: The Future of Hyperimmune-Related Diseases?
New
Hangzhou, China. In J Interferon Cytokine Res, 08 Apr 2013
It contains Epstein-Barr virus-induced gene 3 subunit and IL-27 p35 subunit.
Neonatal macrophages express elevated levels of interleukin-27 that oppose immune responses.
New
Columbia, United States. In Immunology, 06 Apr 2013
Here we show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
IL-27 inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression.
New
Copenhagen, Denmark. In Microcirculation, 02 Apr 2013
OBJECTIVE: IL-27 belongs to the IL-12 family of cytokines and is recognized for its role in Th cell differentiation and as an inhibitor of tumor-angiogenesis.
Independent and Interdependent Immunoregulatory Effects of IL-27, IFN-β, and IL-10 in the Suppression of Human Th17 Cells and Murine Experimental Autoimmune Encephalomyelitis.
New
Belfast, United Kingdom. In J Immunol, 01 Apr 2013
IFN-β, IL-27, and IL-10 have been shown to exert a range of similar immunoregulatory effects in murine and human experimental systems, particularly in Th1- and Th17-mediated models of autoimmune inflammatory disease.
A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours.
New
Chicago, United States. In Br J Cancer, 28 Mar 2013
Background:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53+ metastatic solid tumours.Methods:A total of 15 patients were administered p28 i.v. as a short infusion three times per week for 4 weeks followed by a 2-week rest under an accelerated titration 3+3 dose escalation design until either a grade 3-related adverse event occurred or the maximum tolerated dose (MTD) was reached.
Interleukin-27: balancing protective and pathological immunity.
Review
New
Impact
Philadelphia, United States. In Immunity, Jan 2013
It has been more than 15 years since the identification of individual interleukin-27 (IL-27) and IL-27 receptor components.
CD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis.
New
São Paulo, Brazil. In Plos One, Dec 2012
We also assessed functionality of the T cells by evaluating the secretion of several inflammatory cytokines (IL-17A, IFN-gamma, IL-2, IL-33, TNF-alpha, IL-21, IL-22, and IL-27), from cell-sorted purified CD4+ and CD8+ T cells isolated from lesional and unaffected skin biopsies of psoriasis patients.
Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?
Review
New
London, United Kingdom. In Acta Paediatr, Nov 2012
Conclusion: Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.
Review
New
Impact
Dallas, United States. In Nat Immunol, Oct 2012
Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines.
Treg cells acquire new directions, cytokines navigate.
New
Impact
Suita, Japan. In Immunity, Oct 2012
(2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation.
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
New
Impact
Philadelphia, United States. In Immunity, Oct 2012
Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells.
Atopic dermatitis and cytokines: the immunoregulatory and therapeutic implications of cytokines in atopic dermatitis--part II: negative regulation and cytokine therapy in atopic dermatitis.
Review
New
Taejŏn, South Korea. In Recent Pat Inflamm Allergy Drug Discov, Sep 2012
Recently, the IL-27, IL-21, and IL-10 cytokines were found to be important components of the counter regulatory mechanism that terminates immune response, and protects the host from excessive immune responses.
Atopic dermatitis and cytokines: recent patents in immunoregulatory and therapeutic implications of cytokines in atopic dermatitis--part I: cytokines in atopic dermatitis.
Review
New
Taejŏn, South Korea. In Recent Pat Inflamm Allergy Drug Discov, Sep 2012
Recently, the roles of new cytokines including IL-16, IL-17, IL-21, IL-22, IL-23, IL-27, IL-31, IL-33, IL-35 and thymus stromal lymphopoietin (TSLP), and Th2 polarization in the immunopathogenesis of skin inflammation and physically injured skin have been described, in addition to roles for IL-4, IL- 5, IL-9, IL-13, IFN-γ and TGF-β.
IL-12 family cytokines: immunological playmakers.
Review
New
Impact
Memphis, United States. In Nat Immunol, Aug 2012
The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35.
Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation.
GeneRIF
Cleveland, United States. In J Immunol, 2012
a new model for maintaining peripheral T cell homeostasis via memory CD4 T cells and CD8(+) DC-derived IL-27 in vivo.
Serum levels of interleukin (IL)-27 in patients with ischemic heart disease.
GeneRIF
Rafsanjān, Iran. In Cytokine, 2011
results showed that the higher serum levels of IL-27 were associated with ischemic heart disease
TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
GeneRIF
Seoul, South Korea. In J Immunol, 2011
TLR2 signaling promotes bleomycin-induced pulmonary fibrosis by inducing IL-27 and chemokine production by respiratory epithelial cells, thereby inhibiting IL-17 production and recruiting inflammatory cells into the lungs.
IL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responses.
GeneRIF
London, United Kingdom. In J Immunol, 2011
the IL-12p35 subunit acts as negative regulator of the developing IL-27 response in this model of arthritis
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.
GeneRIF
Columbus, United States. In Anticancer Res, 2011
Gankyrin overexpression is a prevalent event in human oral cancer and occurs during the early stages of oral carcinogenesis, thus being a viable therapeutic or chemopreventive target in oral cancer
