Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections.
London, United Kingdom. In J Interferon Cytokine Res, 25 Mar 2015
The underlying mechanisms by which type I IFNs promote susceptibility or severity include direct tissue damage by apoptosis induction or suppression of proliferation in tissue cells, immunopathology due to excessive inflammation, and cell death induced by TRAIL- and Fas-expressing immune cells, as well as immunosuppression through IL-10, IL-27, PD-L1, IL-1Ra, and other regulatory molecules that antagonize the induction or action of IL-1, IL-12, IL-17, IFN-γ, KC, and other effectors of the immune response.
Effects of statins on TH1 modulating cytokines in human subjects.
Buffalo, United States. In Peerj, Dec 2014
The goal of our study was to assess the TH1 modulating cytokines IL-12 p40 and IL-18, and their counter regulatory cytokines IL-18 binding protein and IL-27, to determine if their levels are linked to cholesterol levels or other factors.
Interleukin-27 in T Cell Immunity.
Tokyo, Japan. In Int J Mol Sci, Dec 2014
IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells.
Platelet transfusion - the new immunology of an old therapy.
Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
Interleukin-12 family cytokines and sarcoidosis.
Sydney, Australia. In Front Pharmacol, 2013
Many T-cell-associated cytokines have been implicated in the immunopathogenesis of sarcoidosis, but it is becoming apparent that IL-12 cytokine family members including IL-12, IL-23, IL-27, and IL-35 are also involved.