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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Jun 2015.

Interleukin 27

P28, IL-27, IL-20
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, IL-12, IL-17, CAN, Interleukin-6
Papers on P28
Plasma Levels of Interleukin 12 Family Cytokines and Their Relevant Cytokines in Adult Patients with Chronic Immune Thrombocytopenia before and after High-Dose Dexamethasome Treatment.
New
Yang et al., Hefei, China. In Med Princ Pract, 23 Jul 2015
OBJECTIVE: We aimed to investigate the expression of interleukin 12 (IL-12) family cytokines (IL-12, IL-23, IL-27 and IL-35) and their relevant cytokines (IFN-γ, IL-4, IL-17A and IL-10) in patients with chronic immune thrombocytopenia (cITP) as well as the effect of high-dose dexamethasone (HD-DXM) treatment on this expression.
Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway.
New
Yang et al., Temple, United States. In J Biol Chem, 17 Jul 2015
We also found that IL-27, which shares EBI3 subunit with IL-35, promoted LPS-induced VCAM-1 in human aortic ECs and that EBI3 deficient mice had similar vascular response to LPS compared with that of WT mice.
Infection with Ehrlichia canis and Anaplasma platys (Rickettsiales: Anaplasmataceae) in two lineages of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) from Argentina.
New
Nava et al., Buenos Aires, Argentina. In Ticks Tick Borne Dis, 14 Jul 2015
Samples were tested for Ehrlichia canis infection by PCR assays using 16S rRNA, dsb and p28 gene, while detection of A. platys was performed with 16S rRNA and groESL gene.
Administration of DNA encoding the interleukin-27 gene augments anti-tumor responses through non-adaptive immunity.
New
Tagawa et al., Chiba, Japan. In Scand J Immunol, 12 Jul 2015
In this study, we examined whether IL-27 DNA administration enhanced anti-tumor effects in mice vaccinated with DNA encoding a putative tumor antigen, β-galactosidase (β-gal).
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
New
Impact
O'Shea et al., Bethesda, United States. In Immunity, 19 Jun 2015
Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique and overlapping functions.
Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27.
Review
New
Liu et al., Shijiazhuang, China. In Int Immunopharmacol, 31 May 2015
Several distinct findings have been highlighted that in certain conditions, neutralizing IL-27 or its subunit IL-27p28 might be a useful strategy to limit inflammation.
Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP.
Review
New
Ferrini et al., Genova, Italy. In J Leukoc Biol, Apr 2015
The natural inhibitor IL-18BP , whose production is enhanced by IFN-γ and IL-27, further regulates IL-18 activity in the extracellular environment.
The Effect of Solar Irradiated Vibrio cholerae on the Secretion of Pro-Inflammatory Cytokines and Chemokines by the JAWS II Dendritic Cell Line In Vitro.
New
Pillay et al., Vanderbijlpark, South Africa. In Plos One, Dec 2014
After 48 hours of stimulation the tissue culture media from each treatment was qualitatively and quantitatively analysed for the presence of IL-1α, IL-1β, IL-6, IL-7, IL-10, IL-12p40, IL-12p70, IL-15, MIP-1α, MIP-1β, MIP-2, RANTES, TNF-α, IL-23 and IL-27.
Dendritic cells change IL-27 production pattern during childhood.
New
Knuf et al., Mainz, Germany. In Bmc Res Notes, Dec 2014
BACKGROUND: Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described.
The immunobiology of interleukin-27.
New
Impact
Hunter et al., Saga, Japan. In Annu Rev Immunol, Dec 2014
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response.
Platelet transfusion - the new immunology of an old therapy.
Review
New
Blumberg et al., Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
The IL-20 subfamily of cytokines--from host defence to tissue homeostasis.
Review
New
Impact
Ouyang et al., San Francisco, United States. In Nat Rev Immunol, Dec 2014
The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26.
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
New
Impact
Ozato et al., Bethesda, United States. In Immunity, Mar 2014
IRF8 induced a cytokine milieu that favored growth and maintenance of Th1 and Th17 cells, by stimulating interleukin-12 (IL-12) and IL-23 production, but inhibiting IL-27 during EAE.
Interleukin-12 family cytokines and sarcoidosis.
Review
Herbert et al., Sydney, Australia. In Front Pharmacol, 2013
Many T-cell-associated cytokines have been implicated in the immunopathogenesis of sarcoidosis, but it is becoming apparent that IL-12 cytokine family members including IL-12, IL-23, IL-27, and IL-35 are also involved.
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Impact
Quintana et al., Boston, United States. In Nat Immunol, 2013
We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE).
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
GeneRIF
Fitzgerald et al., Ireland. In J Immunol, 2012
IL-27 suppresses granulocyte-macrophage colony stimulating factor (GM-CSF) expression in human T cells.
Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells.
GeneRIF
Kapsenberg et al., Amsterdam, Netherlands. In J Leukoc Biol, 2012
viral dsRNA-activated human dendritic cells produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells.
Immunoregulatory function of IL-27 and TGF-β1 in cardiac allograft transplantation.
GeneRIF
Chiffoleau et al., Nantes, France. In Transplantation, 2012
IL-27 and TGF-beta1 have roles in response to cardiac allograft transplantation
Human TCRγδ+ T cells represent a novel target for IL-27 activity.
GeneRIF
Airoldi et al., Genova, Italy. In Eur J Immunol, 2012
results highlighted a novel immunoregulatory property of human IL-27 that may be relevant in the immune response against tumors
Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity.
GeneRIF
Weigert et al., Frankfurt am Main, Germany. In Eur J Immunol, 2012
Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion
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