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Peptidase inhibitor 15

P25TI, SugarCrisp, PI15, peptidase inhibitor 15
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Trypsin, ACID, CRISPLD2, V1a, TTF-2
Papers on P25TI
Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo.
Richman et al., Vancouver, Canada. In Dev Biol, Dec 2015
We also observed expression changes in several poorly characterized genes including the upregulation of Peptidase Inhibitor-15 (PI15).
Analysis of microarray-identified genes and microRNAs associated with drug resistance in ovarian cancer.
Li et al., Nanning, China. In Int J Clin Exp Pathol, 2014
Nine microRNAs (microRNA-199a-5p, microRNA-199a-3p, microRNA-199b-3p, microRNA-215, microRNA-335, microRNA-18b, microRNA-363, microRNA-645 and microRNA-141) and 38 genes were identified to be differentially expressed in drug-resistant ovarian cancer cells, with seven genes (NHSL1, EPHA3, USP51, ZSCAN4, EPHA7, SNCA and PI15) exhibited exactly the same expression trends in all three microarrays.
Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias.
Yang et al., Nashville, United States. In Bmc Genomics, 2014
This analysis identified 58 transcripts that are associated with mild vs severe disease (categorical analysis), including those with established role in fibrosis (ADAMTS4, ADAMTS9, AGER, HIF-1α, SERPINA3, SERPINE2, and SELE) as well as novel IIP candidate genes such as rhotekin 2 (RTKN2) and peptidase inhibitor 15 (PI15).
Identification of 33 candidate oncogenes by screening for base-specific mutations.
Aaltonen et al., Helsinki, Finland. In Br J Cancer, 2014
Fourteen genes displayed mutations in the validation set of 254 MSI CRCs: ANTXR1, MORC2, CEP135, CRYBB1, GALNT9, KRT82, PI15, SLC36A1, CNTF, GLDC, MBTPS1, OR9Q2, R3HDM1 and TTPAL.
Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics.
Mukherjee et al., Rochester, United States. In Bioconjug Chem, 2014
The importance of this methodology and the biological significance of the network proteins were validated by a functional study of three hubs that exhibited variable connectivity, namely, PPA1, SMNDC1, and PI15.
Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery.
Dotrelova et al., Praha, Czech Republic. In Eur J Ophthalmol, 2010
Each animal received a single dose of either 30 mg of carboplatin by periocular injection (POI30 group: n = 6) or 15 mg by periocular injection (PI15 group: n = 6), or 0.05 mg by transcorneal intravitreal injection (TII group: n = 6), respectively, into the right eye.
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.
O'Bryan et al., Australia. In Endocr Rev, 2008
The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins.
Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo.
Tabin et al., Boston, United States. In Mech Dev, 2001
Here we describe the cloning of a novel member of this family, SugarCrisp, and its expression pattern throughout chicken embryogenesis.
A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor.
Sweezey et al., Montréal, Canada. In Am J Physiol, 1999
The predicted LGL1 gene product (lgl1) showed 81% homology to P25TI, a polypeptide trypsin inhibitor recently identified in human glioblastoma and neuroblastoma cells but not detected in normal human tissues.
cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells.
Miyazaki et al., Tokyo, Japan. In Biochim Biophys Acta, 1998
A novel trypsin inhibitor (P25TI) with an apparent molecular size of 25 kDa has previously been purified from the culture medium of human glioblastoma cells.
Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells.
Miyazaki et al., Yokohama, Japan. In J Biochem, 1996
In addition, a novel 25-kDa trypsin-binding protein, tentatively named p25TI, was identified.
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