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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Envoplakin

p210
Top mentioned proteins: BCR, ABL, cdc25, CAN, HAD
Papers on p210
Inhibition of crosstalk between Bcr-Abl and PKC signaling by PEITC, augments imatinib sensitivity in chronic myelogenous leukemia cells.
New
Mukherjee et al., Calcutta, India. In Chem Biol Interact, Jan 2016
Reciprocal translocation of chromosomes 9 and 22, results into Bcr-Abl fusion and is responsible for expression of a tyrosine kinase protein p210(bcr/abl), which mediates several survival pathways and confer therapeutic resistance.
Unsupervised explorative data analysis of normal human leukocytes and BCR/ABL positive leukemic cells mid-infrared spectra.
New
Sorio et al., Verona, Italy. In Analyst, Aug 2015
We analyzed by microFTIR human polymorphonuclear neutrophil (PMNs) leukocytes, mouse-derived parental Ba/F3 cells (Ba/F3#PAR), Ba/F3 cells transfected with p210(BCR/ABL) (Ba/F3#WT) and expressing high levels of protein tyrosine kinase (PTK), and human-derived BCR/ABL positive K562 leukemic cell sub-clones engineered to differently express receptor-type tyrosine-protein phosphatase gamma (PTPRG).
Rare but authentic Philadelphia-positive acute myeloblastic leukemia: two case reports and a literature review of characteristics, treatment and outcome.
Review
New
Reman et al., Caen, France. In Hematol Oncol Stem Cell Ther, Mar 2015
Molecular analysis showed 59% p210 and 41% p190 fusion protein.
[Imatinib is effective in a 12-month-old boy with chronic myelogenous leukemia: case report and literature review].
New
Yan et al., In Zhonghua Er Ke Za Zhi, Mar 2015
The t (9; 22))q34; q11) could be detected and BCR-ABL (p210) was positive.
Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line.
Chen et al., Fuzhou, China. In Peerj, 2014
Western blot was used to detect expression of p21, Akt, pAkt, p210, Acetyl-Histone H3, and Acetyl-Histone H4 proteins.
Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia.
Review
Baskaran et al., Pondicherry, India. In Leuk Res Treatment, 2014
BCR-ABL is a functional oncoprotein p210 that exhibits constitutively activated tyrosine kinase causing genomic alteration of hematopoietic stem cells.
Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice.
Shah et al., Los Angeles, United States. In Plos One, 2014
We recently reported that immunization with apoB-100 related peptide, p210, modified CD8+ T cell function in angiotensin II (AngII)-infused apoE (-/-) mice.
Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.
Impact
Xue et al., Iowa City, United States. In Cell Stem Cell, 2012
Targeting GABPβ1L/β2 also impairs LSC self-renewal in p210(BCR-ABL)-induced chronic myelogenous leukemia (CML) and exhibits synergistic effects with tyrosine kinase inhibitor imatinib therapy in inhibiting CML propagation.
BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias.
Review
Fazio et al., Roma, Italy. In Curr Mol Med, 2012
Philadelphia (Ph+) positive leukaemias are an example of haematological malignant diseases where different chromosomal rearrangements involving both BCR and ABL1 genes generate a variety of chimeric proteins (BCR/ABL1 p210, p190 and p230) which are considered pathological "biomarkers".
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Detection of anti-envoplakin and anti-periplakin autoantibodies by ELISA in patients with paraneoplastic pemphigus.
GeneRIF
Zhu et al., Beijing, China. In Arch Dermatol Res, 2009
autoantibodies are detected in patients with paraneoplastic pemphigus
[Chronic myeloid leukemia in the 21st century: biology and treatment].
Review
Mayani et al., Moscow, Russia. In Rev Invest Clin, 2009
Chronic Myeloid Leukaemia (CML) is a clonal disease, originated at the level of Hematopoietic Stem Cells (HSC) and characterized by the presence of the Philadelphia (Ph) chromosome and its oncogenic product p210(BcrAbl).
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.
Impact
Stacey et al., Australia. In Science, 2009
Conversely, the related pyrin domain-containing HIN-200 factor, AIM2 (p210), was required for caspase activation by cytoplasmic dsDNA.
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
Review
Williams et al., Cincinnati, United States. In Leukemia, 2008
Chronic myelogenous leukemia (CML) is a malignant disease characterized by expression of p210-BCR-ABL, the product of the Philadelphia chromosome.
Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.
GeneRIF
Watt et al., Cambridge, United Kingdom. In J Cell Biol, 2008
Thus, combined loss of the cornified envelope proteins not only impairs the epidermal barrier, but also changes the composition of T cell subpopulations in the skin.
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.
Impact
Williams et al., Cincinnati, United States. In Cancer Cell, 2007
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by expression of the p210-BCR-ABL fusion protein.
Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas.
GeneRIF
Masuda et al., Morioka, Japan. In Oncol Rep, 2005
EVPL might not be the target gene responsible for oesophageal cancer, despite its strong candidacy in terms of character and localization
Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial.
Impact
Lauria et al., Siena, Italy. In Lancet, 2005
We investigated whether a vaccine targeting the BCR-ABL-derived p210 fusion protein was an active and specific immunotherapy.
Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia.
GeneRIF
Steven et al., Bethesda, United States. In J Biol Chem, 2004
envoplakin and periplakin bind to the plasma membrane upon elevation of intracellular [Ca(2+)] in differentiating keratinocytes, where they serve as a scaffold for cornified cell envelope assembly
Critical role for Gab2 in transformation by BCR/ABL.
Impact
Neel et al., Boston, United States. In Cancer Cell, 2002
p210 BCR/ABL is an activated tyrosine kinase that phosphorylates itself and several cellular signaling proteins.
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