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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Cyclin-dependent kinase inhibitor 1A

p21, Cyclin-Dependent Kinase Inhibitor p21, CIP1, K-ras, WAF1, H-ras
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: p53, PCNA, CAN, V1a, p27
Papers using p21 antibodies
Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma
Supplier
Li Ji-Cheng et al., In International Journal of Biological Sciences, 2011
... P21 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
Supplier
Kong Dexin et al., In International Journal of Molecular Sciences, 2009
... Anti-Cip1/WAF-1/p21 antibody was from Milipore.
Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation
Supplier
Rodemann H Peter et al., In Breast Cancer Research : BCR, 2009
... Inhibitors against PI3K (LY294002), MEK (PD98059) and anti-K-Ras antibody were purchased from Merck Biosciences (Darmstadt, Germany) ...
GSK3beta: role in therapeutic landscape and development of modulators
Supplier
Yoo Lina I et al., In BMC Urology, 2009
... The monoclonal p21 antibody was obtained from BD Biosciences (San Diego, CA) ...
Weak p53 permits senescence during cell cycle arrest.
Supplier
El-Deiry Wafik S., In PLoS ONE, 2009
... HT1080-p21-9 cells were cultured in high-glucose DMEM without puruvate supplemented with FC2 serum (HyClone FetalClone II from Thermo Scientific, Logan, Utah) ...
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Papers on p21
P21 activated kinases: Structure, regulation, and functions.
Review
New
Minden et al., United States. In Small Gtpases, 21 Apr 2014
UNLABELLED: The p21 activated kinases (Paks) are well known effector proteins for the Rho GTPases Cdc42 and Rac.
Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI.
New
Zhao et al., Xi'an, China. In Oncol Rep, 21 Apr 2014
The pcDNA3.1(+)-ARHI group exhibited higher expression levels of p53, p21 and p27, and lower levels of cyclin D1, CDK4 and CDK6 when compared to the control group (P<0.05).
Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control.
New
Impact
Sonenberg et al., Montréal, Canada. In Cell Stem Cell, 12 Apr 2014
Loss of 4E-BP expression attenuates the induction of iPSCs at least in part through increased translation of p21, a known inhibitor of somatic cell reprogramming.
Spatial regulation of tumor cell protrusions by RhoC.
Review
New
Condeelis et al., United States. In Cell Adh Migr, 07 Apr 2014
Rho-family of p21 small GTPases plays a direct role in regulating the actin dynamics in these intracellular compartments.
Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins.
New
Pichika et al., Kuala Lumpur, Malaysia. In Eur J Med Chem, 03 Apr 2014
The results showed that 20 apoptotic markers (Bad, Bax, Bcl-2, Bcl-w, Bid, Bim, CD40, Fas, HSP27, IGF-1, IGFBP-4, IGFBP-5, Livin, p21, Survivin, sTNF-R2, TRAIL-R2, XIAP, caspase-3 and caspase-8) were either up regulated or down regulated.
Clock genes: Their role in colorectal cancer.
Review
New
Gazouli et al., Athens, Greece. In World J Gastroenterol, 28 Mar 2014
Recent data support that molecules such as CLOCK1, BMAL1 and PER and CRY proteins have various effects on c-Myc/p21 and Wnt/β-catenin pathways and influence multiple steps of DNA damage response playing a critical role in the preservation of genomic integrity in normal and cancer cells.
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.
New
Impact
Bar-Sagi et al., New York City, United States. In Cancer Cell, 10 Mar 2014
Here, we show that downregulation of wild-type H-Ras or N-Ras in mutant K-Ras cancer cells leads to hyperactivation of the Erk/p90RSK and PI3K/Akt pathways and, consequently, the phosphorylation of Chk1 at an inhibitory site, Ser 280.
Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.
New
Impact
Yap et al., Brisbane, Australia. In Nat Cell Biol, 28 Feb 2014
Further, we find that cells are extruded from monolayers when this pattern of intra-junctional contractility is disturbed, either when N-WASP redistributes into lateral junctions in H-Ras(V12)-expressing cells or on mosaic redistribution of active N-WASP itself.
The Roles of P53R2 in Cancer Progression based on the new function of mutant p53 and cytoplasmic p21.
Review
New
Ahmadi et al., Tabrīz, Iran. In Life Sci, 28 Feb 2014
In this article, we present a viable hypothesis about the roles of p53R2 in cancer progression and therapy resistance based on the roles of cytoplasmic p21 and mutant p53.
Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
New
Ismail et al., In Tumori, Jan 2014
K-ras gene mutations contribute to the pathogenesis of colorectal cancer.
PAK signalling during the development and progression of cancer.
Review
New
Impact
Chernoff et al., In Nat Rev Cancer, Jan 2014
p21-Activated kinases (PAKs) are positioned at the nexus of several oncogenic signalling pathways.
Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling.
New
Yang et al., Seoul, South Korea. In Plos One, Dec 2013
The expressions of KGF, p21, TNF-α and IL-1β, which are keratinocyte terminal differentiation markers associated with catagen, were modulated by treatment with Astragaloside IV.
Role of the protein tyrosine phosphatase shp2 in homeostasis of the intestinal epithelium.
New
Matozaki et al., Kōbe, Japan. In Plos One, Dec 2013
The colitis as well as the reduction in the number of goblet cells apparent in Shp2 CKO mice were normalized by expression of an activated form of K-Ras in IECs.
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
New
Impact
Shokat et al., San Francisco, United States. In Nature, Dec 2013
Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies.
CD99 Drives Terminal Differentiation of Osteosarcoma Cells by Acting as a Spatial Regulator of ERK 1/2.
New
Scotlandi et al., Bologna, Italy. In J Bone Miner Res, Dec 2013
Through cytoplasmic ERK, CD99 promotes activity of the main osteogenic transcriptional factors AP1 and RUNX2, which in turn enhance osteocalcin and p21(WAF1/CIP1) , leading to G0 /G1 arrest.
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
GeneRIF
Pritchard et al., Leicester, United Kingdom. In Genes Dev, 2012
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant
Autophagic activity dictates the cellular response to oncogenic RAS.
GeneRIF
Lu et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 2012
ASPP2 modulates oncogenic RAS-induced autophagic activity to dictate the cellular response to RAS: to proliferate or senesce.
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.
GeneRIF
Hall et al., New York City, United States. In J Cell Biol, 2012
It was concluded that extracellular kinase-mediated up-regulation of c-myc by K-Ras or B-Raf oncogenes disrupts the establishment of apical/basolateral polarity in colon epithelial cells independently of its effect on proliferation.
[What is the prognostic importance of molecular genetic factors in endometrial carcinoma?].
GeneRIF
Spaček et al., United Kingdom. In Klin Onkol, 2011
possible role of K- ras mutation as an early event in the process of endometrial carcinogenesis in type 1 tumors
[Small molecules--principal participants of pathogenesis of rheumatoid arthritis].
Review
GeneRIF
Dubikov et al., In Klin Med (mosk), 2011
[review] Small molecules like p21 and PUMA may play a role in the pathogenesis of rheumatoid arthritis.
More papers using p21 antibodies
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
Supplier
Li Long-Cheng et al., In Molecular therapy. Nucleic acids, 2008
... Immunodetection proceeded by incubating slides overnight at 4 °C with primary antibody specific to p21 (Cell Signaling Technology, Danvers, MA) diluted ...
A dual role of p53 in the control of autophagy.
Supplier
Abdel-Naim Ashraf B., In PLoS ONE, 2007
... Primary antibodies, including p53, phospho-p53 (Ser15), phospho-p53 (Thr55), p21, sequestosome 1 (SQSTM1/p62), and survivin, were purchased from Santa Cruz Biotechnology, Santa Cruz, CA ...
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
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Swarbrick Alexander, In PLoS ONE, 2007
... Rabbit anti-p53(FL-393), mouse anti-p63(4A4), rabbit anti-GADD45α(C-20) and rabbit anti-p21(C-19) were purchased from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
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Cook John A. et al., In Frontiers in Oncology, 2007
... (Fremont, CA, USA); rabbit polyclonal IGF-1Rβ, p21 antibodies, and PARP-1 (F-2) were from Santa Cruz Biotechnology, Inc ...
Complementary functions of ATM and H2AX in development and suppression of genomic instability
Supplier
Malle Ernst et al., In DNA Repair, 2007
... , termed γ-H2AX, Cell Signaling Technology, Beverly, MA, USA); (vi) rabbit monoclonal anti-p21 Waf1/Cip1 antibody (12D1, Cell Signaling Technology, Beverly, MA, USA), ...
Biological roles of estrogen and progesterone in human endometrial carcinoma—new developments in potential endocrine therapy for endometrial cancer
Supplier
DeMayo Francesco J. et al., In Journal of Oncology, 2006
... K-ras mutation, total RNA was isolated from uterus according to, Qiagen minieasy kit protocol ...
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
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Deb Sumitra, In PLoS ONE, 2006
... Anti-human MDM2 (SMP14) and p21 (C19) antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Stopping ras in its tracks.
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Cebecauer Marek, In PLoS ONE, 2006
... Mouse anti-pan-Ras (Ab-3) and mouse monoclonal anti-K-Ras antibodies (mAbs) were obtained from Calbiochem, rabbit anti-β-tubulin antibodies (Abs) from Santa Cruz Biotechnology, mouse anti-phospho-ERK Ab from ...
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
Supplier
Arlt Alexander, In PLoS ONE, 2005
... Anti-luciferase antibody came from Promega, anti-nucleolin and anti-IκB antibody from Santa Cruz Biotechnology, anti-HIF-1α and anti-p21 antibody were from BD Biosciences.
The anti-angiogenic peptide anginex disrupts the cell membrane
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Yang K-D et al., In Cell Death & Disease, 2005
... Antibodies to â-actin, H-Ras, and K-Ras were purchased from Abcam Cambridge Science Park (Cambridge, ...
The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites
Supplier
Townsend Danyelle M. et al., In International Journal of Cell Biology, 2005
... (Millipore), and anti-c-Myc/anti-Cyclin D1/anti-p21 (Cell Signaling).
Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
Supplier
Kuwano Kazuyoshi et al., In Oncoimmunology, 2005
... Antibodies used were rabbit anti-LC3 (Novus), rabbit anti-ATG5 (Novus), mouse anti-p21 (Cell signaling Technology), rabbit anti-phospho-histone H2A.X ...
The structure and regulation of vinculin
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Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... ON), α5 integrin (WB: 1/1,000) (AB1928, Millipore, Temecula, CA), αV integrin (WB: 1/1,000) (AB1930, Millipore), p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) ...
Hsp70-2 is required for tumor cell growth and survival
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O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal anti p53 antibody (DO-1) and rabbit polyclonal anti-p21 antibody (SC-397) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
Supplier
Wang X et al., In Cell Death and Differentiation, 2004
... Autophagy antibody kits and p21 antibody were from Cell Signaling (Beverly, MA, USA) ...
Image Processing with ImageJ
Supplier
Goldfinger Lawrence E. et al., In Small GTPases, 2003
... α-R-Ras, α-H-Ras, α-GFP and α-p110α antibodies were purchased from Santa Cruz Biotechnology.
Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
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Manié S N et al., In Cell Death & Disease, 2002
... Santa-Cruz, Le perray en Yvelines, France), anti-ATG5 (D1G9, Cell Signaling, Montigny le Bretonneux, France), anti-p21 Waf1/Cip1 (DCS60, Cell Signaling), anti-Raptor (24C12, Cell Signaling), ...
Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling
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Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 2002
... Anti–H-Ras Ab (C-20) and anti–K-Ras Ab (F234) were purchased from Santa Cruz Biotechnology, Inc ...
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways
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Dobbelstein Matthias et al., In The Journal of Cell Biology, 2002
... and siRNA control #2, were purchased from Ambion (with the exception of the siRNA to p21, which was purchased from Santa Cruz Biotechnology, Inc.) and are described ...
Mitomycin C induces apoptosis and caspase-8 and −9 processing through a caspase-3 and Fas-independent pathway.
Supplier
Hong Show-Jen et al., In Molecular Vision, 2001
... and p21 were purchased from Santa Cruz Biotechnology Inc ...
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Supplier
Nelson Jay A., In PLoS Pathogens, 2001
... α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, α-p21 (all four from Santa Cruz Biotechnology).
Reovirus as an oncolytic agent against experimental human malignant gliomas
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Lee P W K et al., In British Journal of Cancer, 2000
... -actin, p65, PUMA, Bax and p21 were purchased from Santa Cruz Biotechnology Inc ...
Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices
Supplier
Roux Pierre et al., In The Journal of Cell Biology, 1999
... The primary antibodies used were anti-p21 (C-19; Santa Cruz Biotechnology, Inc.), anti-p53 (DO-1; Novocastra), ...
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Supplier
Sessa William C. et al., In The Journal of Cell Biology, 1999
... Antibodies against PECAM-1 (clone M-20), p16 (clone C-20), and p21 (clone C-19) were obtained from Santa Cruz Biotechnology, Inc ...
Regulation of the MEF2 family of transcription factors by p38
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Rotwein Peter et al., In The Journal of Cell Biology, 1998
... Antibodies to p21 and CDK-4 used for immunoblotting were purchased from Santa Cruz Biotechnology, Inc ...
mdm-2 gene amplification in 3T3-L1 preadipocytes
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Berberich Steven J. et al., In Aging (Albany NY), 1998
... HdmX polyclonal antibody (Bethyl Laboratories, Inc.), p21 polyclonal antibody C-19 (Santa Cruz Biotechnology, Inc.), p53 ...
Corticothalamic connections of extrastriate visual areas in rhesus monkeys
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Levitt Pat et al., In Cerebral Cortex (New York, NY), 1996
... Briefly, P0 brains were sectioned at 20 μM with a cryostat, and P7–P21 brains were sectioned at 40 μM with a freezing sliding microtome (Leica).
Subregion- and cell type-restricted gene knockout in mouse brain.
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Albertson Dawn N., In PLoS ONE, 1995
... pThyLSL-EGFP-F was created by cloning the fragment encoding EGFP fused to the H-Ras farnesylation site from pEGFP-F (BD Biosciences, Mountain View, CA) into ...
Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
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Daoud Sayed S et al., In Breast Cancer Research, 1995
... Primary antibodies against p53 and p21 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); Hsp ...
Stages of embryonic development of the zebrafish.
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Hotchin Neil, In PLoS ONE, 1994
... The following antibodies were used: Goat polyclonal antibody against the NRP-1-C-terminal domain, anti-GIPC, anti-p53 and anti-p21 were purchased from Santa Cruz Biotechnology, Inc ...
TGFβ induces SIK to negatively regulate type I receptor kinase signaling
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Moustakas Aristidis et al., In The Journal of Cell Biology, 1993
... and anti-Flag (M5) antibodies were obtained from Sigma-Aldrich; anti-GFP (A11122) from Invitrogen; anti–PAI-1 and anti-p21 (Cip1/WAF1) from BD Biosciences; anti-HA (Y-11), anti-TβRI (V-22), ...
MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy
Supplier
Mohammad Ramzi M. et al., In Oncogene, 1993
... Primary antibodies for p53, Bax, MDM2 and p21 were purchased from Cell Signaling (Beverly MA) ...
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