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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Aug 2015.

Cyclin-dependent kinase inhibitor 1A

p21, Cyclin-Dependent Kinase Inhibitor p21, CIP1, K-ras, WAF1, H-ras
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: p53, PCNA, V1a, CAN, p27
Papers using p21 antibodies
Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma
Supplier
Li Ji-Cheng et al., In International Journal of Biological Sciences, 2011
... P21 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
Supplier
Kong Dexin et al., In International Journal of Molecular Sciences, 2009
... Anti-Cip1/WAF-1/p21 antibody was from Milipore.
Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation
Supplier
Rodemann H Peter et al., In Breast Cancer Research : BCR, 2009
... Inhibitors against PI3K (LY294002), MEK (PD98059) and anti-K-Ras antibody were purchased from Merck Biosciences (Darmstadt, Germany) ...
GSK3beta: role in therapeutic landscape and development of modulators
Supplier
Yoo Lina I et al., In BMC Urology, 2009
... The monoclonal p21 antibody was obtained from BD Biosciences (San Diego, CA) ...
Weak p53 permits senescence during cell cycle arrest.
Supplier
El-Deiry Wafik S., In PLoS ONE, 2009
... HT1080-p21-9 cells were cultured in high-glucose DMEM without puruvate supplemented with FC2 serum (HyClone FetalClone II from Thermo Scientific, Logan, Utah) ...
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Papers on p21
Mechanism of the inhibition of leukemia cell growth and induction of apoptosis through the activation of ATR and PTEN by the topoisomerase inhibitor 3EZ, 20Ac-ingenol.
Review
New
Sawada et al., Tokyo, Japan. In Leuk Res, 30 Sep 2015
In further experiments, p53 protein expression was increased, and H2AX phosphorylation and p21 protein expression were induced after treatment with 3EZ, 20Ac-ingenol.
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
New
Impact
Bivona et al., San Francisco, United States. In Nat Med, 24 Sep 2015
Reactivation of the MAPK pathway via either a gain in the number of copies of the gene encoding wild-type K-RAS (KRAS(WT)) or decreased expression of the MAPK phosphatase DUSP6 promoted resistance to ALK inhibitors in vitro, and each was associated with resistance to ALK inhibitors in individuals with EML4-ALK-positive lung adenocarcinoma.
SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.
New
Impact
Hancock et al., Houston, United States. In Science, 21 Sep 2015
K-Ras, which is targeted to the plasma membrane by electrostatic interactions with phosphatidylserine, in turn undergoes enhanced nanoclustering.
Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma.
New
Maekawa et al., Gifu, Japan. In Int J Cancer, 08 Sep 2015
The shRNA-mediated knockdown of S100P expression inhibited the proliferation in vitro and in vivo, and migration of CCA cells, arrested cell cycle with the up-regulated expression of cell cycle arrest related factors, p21, p27, GADD45A, and 14-3-3 zeta.
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
New
Impact
Forbes et al., Niigata, Japan. In Nat Cell Biol, 31 Aug 2015
Here, we describe a mouse model where the E3 ubiquitin ligase Mdm2 is inducibly deleted in more than 98% of hepatocytes, causing apoptosis, necrosis and senescence with nearly all hepatocytes expressing p21.
Keap1-Nrf2 signalling in pancreatic cancer.
Review
New
Charnley et al., Edinburgh, United Kingdom. In Int J Biochem Cell Biol, 31 Aug 2015
Upregulation of Nrf2 is, at least in part, K-Ras oncogene-driven and contributes to pancreatic cancer proliferation and chemoresistance.
Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway.
New
Ji et al., Xi'an, China. In Oncotarget, 17 Aug 2015
Mechanically, SFN inhibited thyroid cancer cell growth and invasiveness through repressing phosphorylation of Akt, enhancing p21 expression by the activation of Erk and p38 signaling cascades, and promoting mitochondrial-mediated apoptosis via reactive oxygen species (ROS)-dependent pathway.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Review
New
Zhang et al., Valhalla, United States. In Oncotarget, Jun 2015
During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging cytometry as exemplified by laser scanning cytometry (LSC) has been used to assess changes in expression of the following nuclear proteins associated with initiation of DNA replication: cyclin A, PCNA, Ki-67, p21(WAF1), DNA replication factor Cdt1 and the smallest subunit of DNA polymerase δ, p12.
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.
New
Impact
Fuchs et al., New York City, United States. In Cell, Mar 2015
Rather, TGF-β transcriptionally activates p21, which stabilizes NRF2, thereby markedly enhancing glutathione metabolism and diminishing effectiveness of anti-cancer therapeutics.
Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement.
New
Impact
Muller et al., Basel, Switzerland. In Nat Cell Biol, Feb 2015
Our data suggest that progressive accumulation of myosin II to the mitotic cell cortex probably requires the Cdk1 activation of both p21-activated kinases, which inhibit myosin recruitment, and of Rho kinase, which stimulates myosin recruitment to the cortex.
Differential Effects of IFN-β on the Survival and Growth of Human Vascular Smooth Muscle and Endothelial Cells.
New
Ueda et al., Chiba, Japan. In Biores Open Access, Dec 2014
The antiproliferative effect on SMC associated with the activation of p21 and increase of G0/G1 arrested cells.
K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
New
Bao et al., Ürümqi, China. In Int J Clin Exp Med, Dec 2014
To investigate the K-ras genetic mutation status in colorectal cancer patients, compare the difference of K-ras genetic mutation rate in Han and Uygur nationality and analyze the influencing factor.
Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy.
Review
New
Fimognari et al., Rimini, Italy. In Oxid Med Cell Longev, Dec 2014
Pomegranate evokes antiproliferative, anti-invasive, and antimetastatic effects, induces apoptosis through the modulation of Bcl-2 proteins, upregulates p21 and p27, and downregulates cyclin-cdk network.
LincRNA-p21: Implications in Human Diseases.
Review
New
Xiong et al., Dongguan, China. In Int J Mol Sci, Dec 2014
Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases.
Rhizoma Paridis Saponins Induces Cell Cycle Arrest and Apoptosis in Non-Small Cell Lung Carcinoma A549 Cells.
New
Tian et al., Chengdu, China. In Med Sci Monit, Dec 2014
Moreover, the results of qRT-PCR and Western blotting showed that p53 and cyclin-dependent kinase 2 (CDK2) were significantly downregulated, and that BCL2, BAX, and p21 were upregulated, by RPS treatment.
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
GeneRIF
Pritchard et al., Leicester, United Kingdom. In Genes Dev, 2012
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant
Autophagic activity dictates the cellular response to oncogenic RAS.
GeneRIF
Lu et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 2012
ASPP2 modulates oncogenic RAS-induced autophagic activity to dictate the cellular response to RAS: to proliferate or senesce.
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.
GeneRIF
Hall et al., New York City, United States. In J Cell Biol, 2012
It was concluded that extracellular kinase-mediated up-regulation of c-myc by K-Ras or B-Raf oncogenes disrupts the establishment of apical/basolateral polarity in colon epithelial cells independently of its effect on proliferation.
[What is the prognostic importance of molecular genetic factors in endometrial carcinoma?].
GeneRIF
Spaček et al., United Kingdom. In Klin Onkol, 2011
possible role of K- ras mutation as an early event in the process of endometrial carcinogenesis in type 1 tumors
[Small molecules--principal participants of pathogenesis of rheumatoid arthritis].
Review
GeneRIF
Dubikov et al., In Klin Med (mosk), 2011
[review] Small molecules like p21 and PUMA may play a role in the pathogenesis of rheumatoid arthritis.
More papers using p21 antibodies
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
Supplier
Li Long-Cheng et al., In Molecular therapy. Nucleic acids, 2008
... Immunodetection proceeded by incubating slides overnight at 4 °C with primary antibody specific to p21 (Cell Signaling Technology, Danvers, MA) diluted ...
A dual role of p53 in the control of autophagy.
Supplier
Abdel-Naim Ashraf B., In PLoS ONE, 2007
... Primary antibodies, including p53, phospho-p53 (Ser15), phospho-p53 (Thr55), p21, sequestosome 1 (SQSTM1/p62), and survivin, were purchased from Santa Cruz Biotechnology, Santa Cruz, CA ...
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
Supplier
Swarbrick Alexander, In PLoS ONE, 2007
... Rabbit anti-p53(FL-393), mouse anti-p63(4A4), rabbit anti-GADD45α(C-20) and rabbit anti-p21(C-19) were purchased from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
Supplier
Cook John A. et al., In Frontiers in Oncology, 2007
... (Fremont, CA, USA); rabbit polyclonal IGF-1Rβ, p21 antibodies, and PARP-1 (F-2) were from Santa Cruz Biotechnology, Inc ...
Complementary functions of ATM and H2AX in development and suppression of genomic instability
Supplier
Malle Ernst et al., In DNA Repair, 2007
... , termed γ-H2AX, Cell Signaling Technology, Beverly, MA, USA); (vi) rabbit monoclonal anti-p21 Waf1/Cip1 antibody (12D1, Cell Signaling Technology, Beverly, MA, USA), ...
Biological roles of estrogen and progesterone in human endometrial carcinoma—new developments in potential endocrine therapy for endometrial cancer
Supplier
DeMayo Francesco J. et al., In Journal of Oncology, 2006
... K-ras mutation, total RNA was isolated from uterus according to, Qiagen minieasy kit protocol ...
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function.
Supplier
Deb Sumitra, In PLoS ONE, 2006
... Anti-human MDM2 (SMP14) and p21 (C19) antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Stopping ras in its tracks.
Supplier
Cebecauer Marek, In PLoS ONE, 2006
... Mouse anti-pan-Ras (Ab-3) and mouse monoclonal anti-K-Ras antibodies (mAbs) were obtained from Calbiochem, rabbit anti-β-tubulin antibodies (Abs) from Santa Cruz Biotechnology, mouse anti-phospho-ERK Ab from ...
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
Supplier
Arlt Alexander, In PLoS ONE, 2005
... Anti-luciferase antibody came from Promega, anti-nucleolin and anti-IκB antibody from Santa Cruz Biotechnology, anti-HIF-1α and anti-p21 antibody were from BD Biosciences.
The anti-angiogenic peptide anginex disrupts the cell membrane
Supplier
Yang K-D et al., In Cell Death & Disease, 2005
... Antibodies to â-actin, H-Ras, and K-Ras were purchased from Abcam Cambridge Science Park (Cambridge, ...
The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites
Supplier
Townsend Danyelle M. et al., In International Journal of Cell Biology, 2005
... (Millipore), and anti-c-Myc/anti-Cyclin D1/anti-p21 (Cell Signaling).
Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
Supplier
Kuwano Kazuyoshi et al., In Oncoimmunology, 2005
... Antibodies used were rabbit anti-LC3 (Novus), rabbit anti-ATG5 (Novus), mouse anti-p21 (Cell signaling Technology), rabbit anti-phospho-histone H2A.X ...
The structure and regulation of vinculin
Supplier
Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... ON), α5 integrin (WB: 1/1,000) (AB1928, Millipore, Temecula, CA), αV integrin (WB: 1/1,000) (AB1930, Millipore), p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) ...
Hsp70-2 is required for tumor cell growth and survival
Supplier
O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal anti p53 antibody (DO-1) and rabbit polyclonal anti-p21 antibody (SC-397) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
Supplier
Wang X et al., In Cell Death and Differentiation, 2004
... Autophagy antibody kits and p21 antibody were from Cell Signaling (Beverly, MA, USA) ...
Image Processing with ImageJ
Supplier
Goldfinger Lawrence E. et al., In Small GTPases, 2003
... α-R-Ras, α-H-Ras, α-GFP and α-p110α antibodies were purchased from Santa Cruz Biotechnology.
Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
Supplier
Manié S N et al., In Cell Death & Disease, 2002
... Santa-Cruz, Le perray en Yvelines, France), anti-ATG5 (D1G9, Cell Signaling, Montigny le Bretonneux, France), anti-p21 Waf1/Cip1 (DCS60, Cell Signaling), anti-Raptor (24C12, Cell Signaling), ...
Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling
Supplier
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 2002
... Anti–H-Ras Ab (C-20) and anti–K-Ras Ab (F234) were purchased from Santa Cruz Biotechnology, Inc ...
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways
Supplier
Dobbelstein Matthias et al., In The Journal of Cell Biology, 2002
... and siRNA control #2, were purchased from Ambion (with the exception of the siRNA to p21, which was purchased from Santa Cruz Biotechnology, Inc.) and are described ...
Mitomycin C induces apoptosis and caspase-8 and −9 processing through a caspase-3 and Fas-independent pathway.
Supplier
Hong Show-Jen et al., In Molecular Vision, 2001
... and p21 were purchased from Santa Cruz Biotechnology Inc ...
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Supplier
Nelson Jay A., In PLoS Pathogens, 2001
... α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, α-p21 (all four from Santa Cruz Biotechnology).
Reovirus as an oncolytic agent against experimental human malignant gliomas
Supplier
Lee P W K et al., In British Journal of Cancer, 2000
... -actin, p65, PUMA, Bax and p21 were purchased from Santa Cruz Biotechnology Inc ...
Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices
Supplier
Roux Pierre et al., In The Journal of Cell Biology, 1999
... The primary antibodies used were anti-p21 (C-19; Santa Cruz Biotechnology, Inc.), anti-p53 (DO-1; Novocastra), ...
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Supplier
Sessa William C. et al., In The Journal of Cell Biology, 1999
... Antibodies against PECAM-1 (clone M-20), p16 (clone C-20), and p21 (clone C-19) were obtained from Santa Cruz Biotechnology, Inc ...
Regulation of the MEF2 family of transcription factors by p38
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Rotwein Peter et al., In The Journal of Cell Biology, 1998
... Antibodies to p21 and CDK-4 used for immunoblotting were purchased from Santa Cruz Biotechnology, Inc ...
mdm-2 gene amplification in 3T3-L1 preadipocytes
Supplier
Berberich Steven J. et al., In Aging (Albany NY), 1998
... HdmX polyclonal antibody (Bethyl Laboratories, Inc.), p21 polyclonal antibody C-19 (Santa Cruz Biotechnology, Inc.), p53 ...
Corticothalamic connections of extrastriate visual areas in rhesus monkeys
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Levitt Pat et al., In Cerebral Cortex (New York, NY), 1996
... Briefly, P0 brains were sectioned at 20 μM with a cryostat, and P7–P21 brains were sectioned at 40 μM with a freezing sliding microtome (Leica).
Subregion- and cell type-restricted gene knockout in mouse brain.
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Albertson Dawn N., In PLoS ONE, 1995
... pThyLSL-EGFP-F was created by cloning the fragment encoding EGFP fused to the H-Ras farnesylation site from pEGFP-F (BD Biosciences, Mountain View, CA) into ...
Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
Supplier
Daoud Sayed S et al., In Breast Cancer Research, 1995
... Primary antibodies against p53 and p21 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); Hsp ...
Stages of embryonic development of the zebrafish.
Supplier
Hotchin Neil, In PLoS ONE, 1994
... The following antibodies were used: Goat polyclonal antibody against the NRP-1-C-terminal domain, anti-GIPC, anti-p53 and anti-p21 were purchased from Santa Cruz Biotechnology, Inc ...
TGFβ induces SIK to negatively regulate type I receptor kinase signaling
Supplier
Moustakas Aristidis et al., In The Journal of Cell Biology, 1993
... and anti-Flag (M5) antibodies were obtained from Sigma-Aldrich; anti-GFP (A11122) from Invitrogen; anti–PAI-1 and anti-p21 (Cip1/WAF1) from BD Biosciences; anti-HA (Y-11), anti-TβRI (V-22), ...
MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy
Supplier
Mohammad Ramzi M. et al., In Oncogene, 1993
... Primary antibodies for p53, Bax, MDM2 and p21 were purchased from Cell Signaling (Beverly MA) ...
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