Bugs and food: a recipe for cancer?
Gainesville, United States. In Cell Metab, 02 Jan 2015
(2014) demonstrated that high-fat diet-induced intestinal dysbiosis promotes cancer development in K-ras(G12Dint) mice without inducing obesity or mucosal inflammation, positioning microbial activities as a central component of diet-induced carcinogenesis.
Stem cells and aberrant signaling of molecular systems in skin aging.
Hong Kong, Hong Kong. In Ageing Res Rev, 07 Dec 2014
Recently, adult skin-resident stem/progenitor cells, growth arrest, senescence or apoptotic death and dysfunction caused by alterations in key signaling genes, such as Ras/Raf/MEK/ERK, PI3K/Akt-kinases, Wnt, p21 and p53, have been shown to play a vital role in skin regeneration.
The Design of Covalent Allosteric Drugs.
Tel Aviv-Yafo, Israel. In Annu Rev Pharmacol Toxicol, Sep 2014
In a recent a promising step in therapeutic drug development, allosteric, disulfide-tethered fragments successfully modulated the activity of a protein kinase and K-Ras.
A20--an omnipotent protein in the liver: prometheus myth resolved?
More papers using
In Adv Exp Med Biol, Dec 2013
The molecular basis for A20's hepatoprotective functions were partially resolved and include blockade of NF-kappaB activation in support of its anti-inflammatory function, inhibition of pro-caspase 8 cleavage in support of its anti-apoptotic function, increasing Peroxisome Proliferator Activated Receptor alpha (PPARalpha) expression in support of its anti-oxidant function, and decreasing Cyclin Dependent Kinase Inhibitor p21 while boosting IL-6/STAT3 proliferative signals as part of its pro-regenerative function.
A dual role of p53 in the control of autophagy.
In PLoS ONE, 2007
... Primary antibodies, including p53, phospho-p53 (Ser15), phospho-p53 (Thr55), p21, sequestosome 1 (SQSTM1/p62), and survivin, were purchased from Santa Cruz Biotechnology, Santa Cruz, CA ... Complementary functions of ATM and H2AX in development and suppression of genomic instability
In DNA Repair, 2007
... , termed γ-H2AX, Cell Signaling Technology, Beverly, MA, USA); (vi) rabbit monoclonal anti-p21 Waf1/Cip1 antibody (12D1, Cell Signaling Technology, Beverly, MA, USA), ... Stopping ras in its tracks.
In PLoS ONE, 2006
... Mouse anti-pan-Ras (Ab-3) and mouse monoclonal anti-K-Ras antibodies (mAbs) were obtained from Calbiochem, rabbit anti-β-tubulin antibodies (Abs) from Santa Cruz Biotechnology, mouse anti-phospho-ERK Ab from ... The structure and regulation of vinculin
In Journal of Cellular Physiology, 2005
... ON), α5 integrin (WB: 1/1,000) (AB1928, Millipore, Temecula, CA), αV integrin (WB: 1/1,000) (AB1930, Millipore), p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) ... Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
In Cell Death & Disease, 2002
... Santa-Cruz, Le perray en Yvelines, France), anti-ATG5 (D1G9, Cell Signaling, Montigny le Bretonneux, France), anti-p21 Waf1/Cip1 (DCS60, Cell Signaling), anti-Raptor (24C12, Cell Signaling), ...