RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
San Francisco, United States. In Nat Med, 24 Sep 2015
Reactivation of the MAPK pathway via either a gain in the number of copies of the gene encoding wild-type K-RAS (KRAS(WT)) or decreased expression of the MAPK phosphatase DUSP6 promoted resistance to ALK inhibitors in vitro, and each was associated with resistance to ALK inhibitors in individuals with EML4-ALK-positive lung adenocarcinoma.
Keap1-Nrf2 signalling in pancreatic cancer.
Edinburgh, United Kingdom. In Int J Biochem Cell Biol, 31 Aug 2015
Upregulation of Nrf2 is, at least in part, K-Ras oncogene-driven and contributes to pancreatic cancer proliferation and chemoresistance.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Valhalla, United States. In Oncotarget, Jun 2015
During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging cytometry as exemplified by laser scanning cytometry (LSC) has been used to assess changes in expression of the following nuclear proteins associated with initiation of DNA replication: cyclin A, PCNA, Ki-67, p21(WAF1), DNA replication factor Cdt1 and the smallest subunit of DNA polymerase δ, p12.
LincRNA-p21: Implications in Human Diseases.
More papers using
Dongguan, China. In Int J Mol Sci, Dec 2014
Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases.
A dual role of p53 in the control of autophagy.
In PLoS ONE, 2007
... Primary antibodies, including p53, phospho-p53 (Ser15), phospho-p53 (Thr55), p21, sequestosome 1 (SQSTM1/p62), and survivin, were purchased from Santa Cruz Biotechnology, Santa Cruz, CA ... Complementary functions of ATM and H2AX in development and suppression of genomic instability
In DNA Repair, 2007
... , termed γ-H2AX, Cell Signaling Technology, Beverly, MA, USA); (vi) rabbit monoclonal anti-p21 Waf1/Cip1 antibody (12D1, Cell Signaling Technology, Beverly, MA, USA), ... Stopping ras in its tracks.
In PLoS ONE, 2006
... Mouse anti-pan-Ras (Ab-3) and mouse monoclonal anti-K-Ras antibodies (mAbs) were obtained from Calbiochem, rabbit anti-β-tubulin antibodies (Abs) from Santa Cruz Biotechnology, mouse anti-phospho-ERK Ab from ... The structure and regulation of vinculin
In Journal of Cellular Physiology, 2005
... ON), α5 integrin (WB: 1/1,000) (AB1928, Millipore, Temecula, CA), αV integrin (WB: 1/1,000) (AB1930, Millipore), p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) ... Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
In Cell Death & Disease, 2002
... Santa-Cruz, Le perray en Yvelines, France), anti-ATG5 (D1G9, Cell Signaling, Montigny le Bretonneux, France), anti-p21 Waf1/Cip1 (DCS60, Cell Signaling), anti-Raptor (24C12, Cell Signaling), ...