RasGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
Salamanca, Spain. In J Cell Sci, Feb 2016
UNASSIGNED: Detailed immunocytochemical analyses comparing WT, GRF1 KO, GRF2 KO and GRF1/2 DKO mouse retinas uncovered the specific accumulation of misplaced, "ectopic" cone photoreceptor nuclei in the photoreceptor segment (PS) area of retinas from GRF2 KO and GRF1/2 DKO, but not of WT or GRF1 KO mice.
Spatial regulation of tumor cell protrusions by RhoC.
United States. In Cell Adh Migr, 2013
Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a "molecular compass" in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion.
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation.
Kyoto, Japan. In Mol Biol Cell, 2012
role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation
A mechanosensitive transcriptional mechanism that controls angiogenesis.
Boston, United States. In Nature, 2009
Here we show that the Rho inhibitor, p190RhoGAP (also known as GRLF1), controls capillary network formation in vitro in human microvascular endothelial cells and retinal angiogenesis in vivo by modulating the balance of activities between two antagonistic transcription factors, TFII-I (also known as GTF2I) and GATA2, that govern gene expression of the VEGF receptor VEGFR2 (also known as KDR).