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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD109 molecule

p180, GARP, GAR1, POLA, CD109, Gar1p
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, ACID, CD45, HAD
Papers using p180 antibodies
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
Serotec), anti-GARP (G14D9, eBioscience), mouse IgG: anti-CD3 (UCHT1, ...
Papers on p180
IL-10/IFNγ co-expressing CD4(+) T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses.
New
Ten Brinke et al., Amsterdam, Netherlands. In Clin Immunol, Jan 2016
Protein analysis confirmed an extensive regulatory phenotype for IL-10(+)/IFNγ(+) T cells, with specific enhanced expression of GARP and PD-1.
CD109 is a component of exosome secreted from cultured cells.
New
Murakumo et al., Nagoya, Japan. In Biochem Biophys Res Commun, Jan 2016
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, and is released from the cell surface to the culture medium in vitro.
Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function.
New
Naash et al., Oklahoma City, United States. In Invest Ophthalmol Vis Sci, Jan 2016
PURPOSE: The beta subunit of the rod cyclic nucleotide gated channel B1 (CNGB1) contains a proline/glutamic acid-rich N-terminal domain (GARP), which is also present in rods as a non-membrane-bound protein (GARP1/2).
Deconstructing the pig sex metabolome: Targeted metabolomics in heavy pigs revealed sexual dimorphisms in plasma biomarkers and metabolic pathways.
New
Fontanesi et al., In J Anim Sci, Dec 2015
Plasma from 545 performance-tested Italian Large White pigs (172 castrated males and 373 females) sampled at about 160 kg live weight were analyzed for 186 metabolites using the Biocrates AbsoluteIDQ p180 Kit.
The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment.
New
Humpel et al., Innsbruck, Austria. In Alzheimers Dement (amst), Oct 2015
METHODS: We analyzed plasma samples from controls (n = 35), MCI (n = 33), and AD patients (n = 43) using the AbsoluteIDQ p180 Kit (Biocrates Life Sciences), which included quantitative analysis of 40 acylcarnitines, 21 amino acids, 19 biogenic amines, 15 sphingolipids, 90 glycerophospholipids, and sum of hexoses.
EARP is a multisubunit tethering complex involved in endocytic recycling.
New
Impact
Bonifacino et al., Bethesda, United States. In Nat Cell Biol, May 2015
Herein we describe a tethering complex named endosome-associated recycling protein (EARP) that is structurally related to the previously described Golgi-associated retrograde protein (GARP) complex.
VPS54 and the wobbler mouse.
Review
Schmitt-John, Århus, Denmark. In Front Neurosci, 2014
The wobbler mutation is a point mutation affecting Vps54, a component of the Golgi-associated retrograde protein (GARP) complex.
Localization of mRNAs to the endoplasmic reticulum.
Review
Palazzo et al., Toronto, Canada. In Wiley Interdiscip Rev Rna, 2014
Recent work has uncovered trans-acting factors, such as the mRNA receptor p180, and cis-acting elements, such as transmembrane domain coding regions, that are responsible for this alternative mRNA localization process.
Human platelet antigens - 2013.
Review
McFarland et al., Milwaukee, United States. In Vox Sang, 2014
Other platelet GP complexes, GPIb/V/IX, GPIa/IIa and CD109, express the remaining 13 HPAs.
Untangling the web: mechanisms underlying ER network formation.
Review
Blackstone et al., Bethesda, United States. In Biochim Biophys Acta, 2013
Flat ER sheets possess a different complement of proteins such as p180, CLIMP-63 and kinectin implicated in shaping, cisternal stacking and cytoskeletal interactions.
Molecular signatures for the phylum Synergistetes and some of its subclades.
Review
Gupta et al., Hamilton, Canada. In Antonie Van Leeuwenhoek, 2012
We report here identification of 32 CSIs in widely distributed proteins such as RpoB, RpoC, UvrD, GyrA, PolA, PolC, MraW, NadD, PyrE, RpsA, RpsH, FtsA, RadA, etc., including a large >300 aa insert within the RpoC protein, that are present in various Synergistetes species, but except for isolated bacteria, these CSIs are not found in the protein homologues from any other organisms.
RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.
Impact
Bloomfield et al., Columbus, United States. In J Clin Oncol, 2012
Because RUNX1 mutations were more common in older patients and almost never coexisted with NPM1 mutations, RUNX1 mutation-associated expression signatures were derived in older, NPM1 wild-type patients and featured upregulation of genes normally expressed in primitive hematopoietic cells and B-cell progenitors, including DNTT, BAALC, BLNK, CD109, RBPMS, and FLT3, and downregulation of promoters of myelopoiesis, including CEBPA and miR-223.
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.
GeneRIF
Pellegrini et al., Cambridge, United Kingdom. In J Biol Chem, 2012
Findings indicate that tethering of primase to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells.
Age-related changes in Cngb1-X1 knockout mice: prolonged cone survival.
GeneRIF
Kraft et al., Birmingham, United States. In Doc Ophthalmol, 2012
These results confirm that rods are marginally functional in the absence of the beta-subunit and in addition show that CFF (critical flicker frequency)may be a more sensitive measure of remaining functional cone vision
GARP regulates the bioavailability and activation of TGFβ.
GeneRIF
Springer et al., Boston, United States. In Mol Biol Cell, 2012
Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation.
The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients.
GeneRIF
Meyers et al., In J Allergy Clin Immunol, 2012
There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels
p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum.
GeneRIF
Palazzo et al., Toronto, Canada. In Plos Biol, 2011
Depletion of p180 in U2OS cells increases cell size.
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
Impact
GeneRIF
Australian Asthma Genetics Consortium et al., Brisbane, Australia. In Lancet, 2011
on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP) associated with asthma risk
KANADI regulates organ polarity in Arabidopsis.
Impact
Poethig et al., Philadelphia, United States. In Nature, 2001
Here we show that KAN is required for abaxial identity in both leaves and carpels, and encodes a nuclear-localized protein in the GARP family of putative transcription factors.
The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions.
Impact
Fournier et al., Amherst Center, United States. In Cell, 1996
All members of the yeast ACA family are associated with the GAR1 protein.
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