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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Non-metastatic cells 2, protein

P18, nm23-H2, NMe2
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: PCNA, CAN, p18, p27, p21
Papers using P18 antibodies
Acetylation Suppresses the Proapoptotic Activity of GD3 Ganglioside
Supplier
Testi Roberto et al., In The Journal of Experimental Medicine, 2000
... Polyclonal antibody against caspase-9 p18 subunit was from Santa Cruz Biotechnology, Inc ...
Papers on P18
Imidazolin-2-iminato Ligand-Supported Titanium Complexes as Catalysts for the Synthesis of Urea Derivatives.
New
Panda et al., Kāndi, India. In Inorg Chem, Feb 2016
UNASSIGNED: The reactions of tetrakis(dimethylamido)titanium(IV) [Ti(NMe2)4] with three different imidazolin-2-imines (Im(R)NH; R = tert-butyl (tBu), mesityl (Mes), and 2,6-diisopropylphenyl (Dipp)) afforded the corresponding titanium imidazolin-2-iminato complexes [(Im(R)N)Ti(NMe2)3] (R = tBu, 1a; R = Mes, 1b; R = Dipp, 1c).
High-Throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation.
New
Screaton et al., Canada. In J Biol Chem, Feb 2016
Here we report the development of a high-throughput RNAi screening strategy specifically for use in primary cells and demonstrate that silencing the cell cycle dependent kinase inhibitors CDKN2C/p18 or CDKN1A/p21 facilitates cell cycle entry of quiescent adult human pancreatic beta cells.
Towards physical interpretation of substituent effects: the case of meta- and para-substituted anilines.
New
Krygowski et al., Warsaw, Poland. In Phys Chem Chem Phys, Feb 2016
UNASSIGNED: Quantum chemical modeling was used to investigate the electron-donating properties of the amino group in a series of meta- and para-X-substituted anilines (X = NMe2, NH2, OH, OMe, CH3, H, F, Cl, CF3, CN, CHO, COMe, CONH2, COOH, NO2, and NO).
Dendrobium candidum inhibits MCF-7 cells proliferation by inducing cell cycle arrest at G2/M phase and regulating key biomarkers.
New
Hu et al., Changchun, China. In Onco Targets Ther, Dec 2015
The messenger RNA levels of estrogen receptor alpha, IGFBP2, IGFBP4, and GATA3 were significantly decreased, and the messenger RNA and protein levels of ELF5, p53, p21, p18, CDH1, CDH2, and p12 were significantly increased, compared to the control group (P<0.05).
Titanium-Catalyzed Multicomponent Couplings: Efficient One-Pot Syntheses of Nitrogen Heterocycles.
New
Impact
McDaniel et al., East Lansing, United States. In Acc Chem Res, Dec 2015
The catalyst can be formed in situ from commercially available Ti(NMe2)4 and the protonated form of the ligand.
p27 and leukemia: cell cycle and beyond.
Review
New
Banerjee et al., Calcutta, India. In J Cell Physiol, Mar 2015
Till date CDKIs are broadly classified into two groups-INK4 family (p15, p16, p18, and p19) and the cip/kip family (p21, p27, and p57).
Inhibition of telomerase activity by NME2: impact on metastasis suppression?
Review
New
Chowdhury et al., New Delhi, India. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Though anti-metastatic function of non-metastatic 2 (NME2) has been implicated in multiple cancers, mechanisms of metastases control by NME2 are not clearly understood.
Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives.
Review
New
Wong et al., Hong Kong, Hong Kong. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Much attention has been focused on the better-known Nm23-H1, but despite having high sequence similarity, Nm23-H2 functions differently in many aspects.
Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs.
Dong et al., Kao-hsiung, Taiwan. In Int J Mol Sci, 2014
Furthermore, by using genechip analysis, we observed that linalool can promote p53, p21, p27, p16, and p18 gene expression.
Stepping Out of the Cytosol: AIMp1/p43 Potentiates the Link Between Innate and Adaptive Immunity.
Review
Decker et al., Houston, United States. In Int Rev Immunol, 2014
Together with other nonenzymatic mARS structural components AIMp2/38 and AIMp3/p18, it participates in the machinery responsible for cell-cycle control and tumor suppression.
Role of cell cycle regulatory molecules in retinoic acid- and vitamin D3-induced differentiation of acute myeloid leukaemia cells.
Review
Zuckerman et al., Miami, United States. In Cell Prolif, 2014
CDK inhibitors (CKIs) of the INK family, such as p15, p16 and p18, are mainly involved in inhibition of cell proliferation, whereas CIP/KIP members, such as p21, regulate both growth arrest and induction of differentiation.
Pro-oncogenic potential of NM23-H2 in hepatocellular carcinoma.
GeneRIF
Kim et al., Chŏnju, South Korea. In Exp Mol Med, 2012
NIH3T3 fibroblasts and HLK3 hepatocytes stably expressing NM23-H2 produced tumors in athymic mice.
Through scaffolding and catalytic actions nucleoside diphosphate kinase B differentially regulates basal and β-adrenoceptor-stimulated cAMP synthesis.
GeneRIF
Wieland et al., Heidelberg, Germany. In Cell Signal, 2011
Nucleoside diphosphate kinase B regulates Gs function by two different mechanisms.
Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1, resulting in defective T cell activation.
GeneRIF
Skolnik et al., New York City, United States. In J Biol Chem, 2011
Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1, resulting in defective T cell activation
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells.
Impact
Goodell et al., Houston, United States. In Nat Cell Biol, 2010
Molecular analysis revealed an association between Nurr1 overexpression and upregulation of the cell-cycle inhibitor p18 (also known as INK4C), suggesting a mechanism by which Nurr1 could regulate HSC quiescence.
Nme gene family evolutionary history reveals pre-metazoan origins and high conservation between humans and the sea anemone, Nematostella vectensis.
GeneRIF
Bobe et al., Marseille, France. In Plos One, 2009
Studies indicate that most of the proteins known to interact with human NME proteins were also found in starlet sea anemone.
A small molecule primes embryonic stem cells for differentiation.
Impact
Schultz et al., Los Angeles, United States. In Cell Stem Cell, 2009
Affinity-based methods revealed that stauprimide interacts with NME2 and inhibits its nuclear localization.
CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.
Impact
Xiong et al., Chapel Hill, United States. In Cancer Cell, 2009
We report that mice deficient for the CDK4/6 inhibitor p18(Ink4c) spontaneously develop ER-positive luminal tumors at a high penetrance.
Measurement of human breast tumor cell-secreted shNDPK-B in a murine breast cancer model suggests its role in metastatic progression.
GeneRIF
Buxton et al., Reno, United States. In Proc West Pharmacol Soc, 2008
further demonstrate that shNDPK-B is released into the circulation in immunocompromized mice carrying the human breast carcinoma cell MDA-MB-
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
Impact
Chin et al., Boston, United States. In Cancer Cell, 2008
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion.
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