GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Cyclin-dependent kinase inhibitor 2A
p16, Cyclin-Dependent Kinase Inhibitor p16, ARF, p16INK4a, CDKN2A, INK4A, p14
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Jul 2008] (from
NCBI)
Top mentioned proteins:
p53, CAN, HAD, AGE, PCNA
Papers using
p16
antibodies
Facile means for quantifying microRNA expression by real-time PCR.
Supplier
In PLoS ONE, 2004
... TCR-LCMV-P14/TCR transgenic (specific for LCMV gp33-41) ...
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
Supplier
In The Journal of Experimental Medicine, 2002
... P14 and OT-1 TCR transgenic mice that were on ...
Clinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomas
Supplier
In Head and Neck Pathology, 2001
... Immunohistochemical staining for p16 (p16INK4a kit; Dako, Carpinteria, CA) and HPV ...
PKCθ Signals Activation versus Tolerance In Vivo
Supplier
In The Journal of Experimental Medicine, 2001
... The P14 TCR transgenic mouse line ( ...
2001 Consensus guidelines for the management of women with cervical cytological abnormalities
more suppliersSupplier
In Clinical Medicine. Pathology, 2001
... Serial sections of the retrieved slides and appropriate controls were immunostained for p16 (Clone JC8 at dilution of 1:200 from Biocare Medical, Concord CA) utilizing Envision ...
Papers on
p16
Definitive intensity-modulated radiotherapy concurrent with systemic therapy for oropharyngeal squamous cell carcinoma: Outcomes from an integrated regional Australian cancer centre.
New
Lismore, Australia. In J Med Imaging Radiat Oncol, Feb 2016
Ninety percent of our patients received concurrent systemic therapy, and 68% were p16 positive.
Human Papillomavirus 16 Physical Status and the TP53 Codon 72 Polymorphism in Japanese HPV-Positive Oropharyngeal Cancer Patients.
New
Tokyo, Japan. In Orl J Otorhinolaryngol Relat Spec, Feb 2016
METHODS: Tumor samples from 70 p16-positive OPSCC patients were tested for HPV-16 physical status by examining the E2 and E6 open reading frames.
Nanopore sequencing detects structural variants in cancer.
New
Baltimore, United States. In Cancer Biol Ther, Feb 2016
We have tested nanopore sequencing to detect a series of well-characterized SVs, including large deletions, inversions, and translocations that inactivate the CDKN2A/p16 and SMAD4/DPC4 tumor suppressor genes in pancreatic cancer.
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
New
Impact
In N Engl J Med, Feb 2016
Type 1 tumors were associated with MET alterations, whereas type 2 tumors were characterized by CDKN2A silencing, SETD2 mutations, TFE3 fusions, and increased expression of the NRF2-antioxidant response element (ARE) pathway.
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.
New
Impact
Chapel Hill, United States. In Cancer Cell, Feb 2016
Unexpectedly, long-term treatment of sensitive cell lines caused senescence, mediated in part by MYC degradation and p16 reactivation.
[Contribution to tumor escape and chemotherapy response: A choice between senescence and apoptosis in heterogeneous tumors].
Review
New
Angers, France. In Bull Cancer, Feb 2016
Activated in response to DNA damage, cell cycle and mitotic checkpoints activate the p53-p21 and p16-Rb pathways and induce apoptosis or senescence.
Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab.
New
Impact
Houston, United States. In J Clin Oncol, Jan 2016
PURPOSE: We conducted a retrospective evaluation of the IMCL-9815 study to examine the association of human papillomavirus (HPV) and p16 protein expression status with outcomes in patients with oropharyngeal carcinoma (OPC) receiving radiotherapy (RT) plus cetuximab or RT alone.
The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.
Review
New
Charleston, United States. In Am J Pathol, Jan 2016
Studies of human neurofibromatosis type 1-associated tumors suggest that NF1 tumor suppressor loss in Schwann cells triggers cell-autonomous and intercellular changes, resulting in development of benign neurofibromas; subsequent neurofibroma-MPNST progression is caused by aberrant growth factor signaling and mutations affecting the p16(INK4A)-cyclin D1-CDK4-Rb and p19(ARF)-Mdm2-p53 cell cycle pathways.
Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression.
Review
New
Gießen, Germany. In Trends Pharmacol Sci, Jan 2016
The ability of CDK6 to trigger the expression of VEGF-A and p16(INK4A) and to recruit the NF-κB subunit p65 to its target sites is largely independent of its kinase function.
So-Called "Massive" Retinal Gliosis: A Critical Review and Reappraisal.
Review
New
Durham, United States. In Surv Ophthalmol, Jan 2016
The non-neoplastic nature of all categories of gliosis was confirmed by absent TP53 (tumor suppressor gene) dysregulation, Ki-67 negativity and intact p16 expression (the protein product of the p16 tumor suppressor gene) in the overwhelming majority of cases.
Incidence of tonsillar cancer in northern Sweden: Impact of human papilloma virus.
New
Umeå, Sweden. In Oncol Lett, Dec 2015
The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV infection in tonsillar tissue.
Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression.
New
Houston, United States. In Sci Rep, Dec 2015
The majority of oncogenes required only amplitude cutoffs, as high amplitude samples were almost invariably focal; however, CDKN2A and PTEN uniquely required both amplitude and length cutoffs as primary predictors.
Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.
New
Impact
Houston, United States. In Nat Genet, Dec 2015
Frequent somatic alterations were identified in TP53, CARD11, CCR4, PLCG1, CDKN2A, ARID1A, RPS6KA1 and ZEB1.
The Genetic Evolution of Melanoma from Precursor Lesions.
New
Impact
Australia. In N Engl J Med, Dec 2015
Biallelic inactivation of CDKN2A emerged exclusively in invasive melanomas.
Mechanisms and Regulation of the Mitotic Inheritance of the Golgi Complex.
Review
Napoli, Italy. In Front Cell Dev Biol, 2014
Most of these events are regulated by small GTPases of the Arf and Rab families.
Stromal p16 expression differentiates endometrial polyp from endometrial hyperplasia.
GeneRIF
Nagoya, Japan. In Virchows Arch, 2012
Stromal p16 expression might be a peculiar characteristic of endometrial polyp and constitute a useful marker for the diagnosis
Human papillomavirus DNA and p16 gene in squamous cell lung carcinoma.
GeneRIF
Brescia, Italy. In Anticancer Res, 2012
study shows that in pulmonary SCC, there is no association between the presence of HPV DNA and the expression of p16 protein
Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.
GeneRIF
London, Canada. In Arch Otolaryngol Head Neck Surg, 2012
6 of 7 HNSCC cell lines were studied, damaging CDKN2A mutations were found in all lines except SCC15.
p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells.
GeneRIF
Rochester, United States. In Neuro Oncol, 2012
High p16(INK4a)is associated with drug sensitivity in glioblastoma.
c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.
More papers using
p16
antibodies
Impact
GeneRIF
Shanghai, China. In Nat Cell Biol, 2012
Identify c-Abl as a regulator of bone morphogenetic protein signalling pathways and uncover a role for c-Abl in p16(INK4a) expression and osteoprogenitor expansion.
Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development
Supplier
In The Journal of Experimental Medicine, 2001
... ), P14 TCR transgenic RAG-2 ...
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells
Supplier
In The Journal of Experimental Medicine, 1999
... The P14 (line 327, reference 23) and H-Y 2425 αβ TCR transgenic lines were maintained on ...
Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
Supplier
In The Journal of Experimental Medicine, 1999
... P14 transgenic mice, which express a TCR ...
Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance
Supplier
In The Journal of Experimental Medicine, 1998
... ), and P14 TCR (33) transgenic lines were interbred to ...
Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells
Supplier
In The Journal of Experimental Medicine, 1997
... BALB/cByJ, C57BL/6J, and P14 LCMV TCR-transgenic mice ...
Altered thymic positive selection and intracellular signals in Cbl-deficient mice
Supplier
In The Journal of Experimental Medicine, 1997
... P14 TCR–transgenic mice (327 line) express ...
Tumor-infiltrating lymphocytes exhibiting high ex vivo cytolytic activity fail to prevent murine melanoma tumor growth in vivo.
Supplier
In PLoS ONE, 1997
... The 2C and P14 TCR-transgenic mice were kindly obtained ...
Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection.
Supplier
In PLoS Pathogens, 1997
... P14 TCR-transgenic mice specific for the ...
Direct and GTP-dependent interaction of ADP-ribosylation factor I with coatomer subunit β
Supplier
In The Journal of Cell Biology, 1996
... Production of Anti-ARF AntibodiesThe full-length coding sequences for ARFs 1, 4, 5, and 6 were amplified by PCR from human brain cDNA (CLONTECH Laboratories, Palo Alto, CA) ...
Dual T cell receptor β chain expression on human T lymphocytes
Supplier
In The Journal of Experimental Medicine, 1994
... The P14 TCR-β transgenic mice (line 128) express ...
Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression
Supplier
In PLoS Biology, 1992
... P14 TCR transgenic mice [ ...
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning
Supplier
In The Journal of Experimental Medicine, 1988
... P14 mice express a transgenic TCR specific for p33 ...
Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection
Supplier
In The Journal of Experimental Medicine, 1986
... P14 TCR-transgenic mice specific for the ...
