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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin-dependent kinase inhibitor 2B

p15, AP-2, Transcription Factor AP-2
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, p16
Papers using p15 antibodies
MYB58 and MYB63 are transcriptional activators of the lignin biosynthetic pathway during secondary cell wall formation in Arabidopsis
Supplier
Pereira Andy et al., In Plant Physiology, 2008
... The SHINE clade of AP2 domain transcription factors activates wax biosynthesis, alters cuticle properties, and ...
Regulation of seed size by hypomethylation of maternal and paternal genomes
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Harada John J. et al., In Sexual Plant Reproduction, 2005
... ap2-7 and transgenic plants carrying ...
Profiling histone modification patterns in plants using genomic tiling microarrays.
Supplier
Waterhouse Peter, In PLoS Pathogens, 2004
... P15, P19 and HcPro expressing lines (in the CHS RNAi background) were described previously [18], as were the P6 transgenic line in the WT ...
Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells.
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Hazen Samuel P., In PLoS ONE, 2002
... nested primers specific to the T-DNA borders in combination with a pair of nested primers (AP1, AP2) specific to the adapters of the Clontech GenomeWalker kit ...
Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network
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Puertollano Rosa et al., In Traffic (Copenhagen, Denmark), 2002
... USA), mouse monoclonal anti-CD63 (H5C6; Pharmingen, San Jose, CA, USA), mouse monoclonal anti-β subunit of AP2 (100/2; Sigma-Aldrich, St Louis, MO, USA), rabbit anti-GFP (MBL International, Woburn, MA, USA), ...
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Papers on p15
Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3.
New
Bernlohr et al., Minneapolis, United States. In Mol Endocrinol, Feb 2016
Prior work using high-fat fed mice has shown that ablation of the adipocyte fatty acid binding protein (FABP4/aP2) in macrophages leads to an anti-inflammatory state both in situ and in vivo and the mechanism is linked, in part, to increased intracellular monounsaturated fatty acids and the up-regulation of UCP2.
Intermedin/Adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice.
New
Wang et al., Beijing, China. In Int J Obes (lond), Feb 2016
METHODS: Wild type (WT) and aP2/AM2 transgenic (aAM2-tg) mice were fed a high-fat diet (HFD) for 8 weeks, and WT mice were treated with AM2 through mini-osmotic pumps.
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.
New
Ivaska et al., Turku, Finland. In Nat Struct Mol Biol, Feb 2016
Here, we found that a subset of α subunits contain an evolutionarily conserved and functional YxxΦ motif directing integrins to selective internalization by the most abundant endocytic clathrin adaptor, AP2.
Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease.
New
Impact
Chan et al., San Francisco, United States. In Cell, Feb 2016
As DENND1B interacts with AP-2 and Rab35, TH2 cells deficient in AP-2 or Rab35 also exhibit enhanced TCR-mediated effector functions.
Is the resulting phenotype of an embryo with balanced X-autosome translocation, obtained by means of preimplantation genetic diagnosis, linked to the X inactivation pattern?
New
Anahory et al., Montpellier, France. In Fertil Steril, Feb 2016
PATIENT(S): Two female patients carriers undergoing PGD for a balanced X-autosome translocations: patient 1 with 46,X,t(X;2)(q27;p15) and patient 2 with 46,X,t(X;22)(q28;q12.3).
Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances.
Review
New
Luo et al., Hangzhou, China. In Seizure, Jan 2016
(FCMTE2), 5p15.31-p15.1 (FCMTE3), and 3q26.32-3q28
MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma.
Review
New
Avan et al., Mashhad, Iran. In Eur J Cancer, Jan 2016
let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes such as NRAS, microphthalmia-associated transcription factor, receptor tyrosine kinase c-KIT, AP-2 transcription factor, etc.
Gene expression regulation in roots under drought.
Review
New
Szarejko et al., Katowice, Poland. In J Exp Bot, Jan 2016
In particular, the role of several transcription factor (TF) families, including DREB, AP2/ERF, NAC, bZIP, MYC, CAMTA, Alfin-like and Q-type ZFP, in the regulation of root response to drought are highlighted.
[The role of long non-coding RNAs in hematologic malignancies].
Review
New
Ai et al., Beijing, China. In Yi Chuan, Nov 2015
These lncRNAs are involved in diseases through diverse functions including affecting the expression of tumor suppressor gene p15, regulating p53 protein function, and interacting with miRNAs.
The complement of family M1 aminopeptidases of Haemonchus contortus - Biotechnological implications.
Review
New
Gasser et al., Melbourne, Australia. In Biotechnol Adv, Nov 2015
X94187, FJ481146 and AJ249941) had most sequence similarity to Hc-AP-2 and Hc-AP-8, whereas unpublished isoforms (accession nos.
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.
New
Impact
Hurley et al., Berkeley, United States. In Science, Nov 2015
The lentiviral Nef protein helps viruses evade innate and adaptive immune defenses by hijacking the adaptor protein 1 (AP-1) and AP-2 clathrin adaptors.
Endophilin marks and controls a clathrin-independent endocytic pathway.
New
Impact
McMahon et al., Cambridge, United Kingdom. In Nature, Feb 2015
Here we show in mammalian cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is independent of AP2 and clathrin, activated upon ligand binding to cargo receptors, inhibited by inhibitors of dynamin, Rac, phosphatidylinositol-3-OH kinase, PAK1 and actin polymerization, and activated upon Cdc42 inhibition.
Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine.
Fang et al., Guiyang, China. In Genet Mol Res, 2014
We evaluated the influence of heme oxygenase-1 (HO-1) gene inhibition in myelodysplastic syndrome (MDS) cell line SKM-1 on enhancement of the demethylating effects of decitabine on p15, and explored the possible mechanism.
Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch.
Impact
Owen et al., Hannover, Germany. In Science, 2014
Assembly polypeptide 2 (AP2) is the most abundant adaptor and is pivotal to CME.
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.
Impact
Waters et al., Glasgow, United Kingdom. In Nature, 2014
Here we show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essential for the commitment of asexually replicating forms to sexual development in Plasmodium berghei, a malaria parasite of rodents.
Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway.
GeneRIF
Cataltepe et al., Boston, United States. In Angiogenesis, 2012
These data unravel a novel pro-angiogenic role for endothelial cell-FABP4 and suggest that it could be exploited as a potential target for diseases associated with pathological angiogenesis
Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease: a 10-year prospective study.
GeneRIF
Brenner et al., München, Germany. In Arterioscler Thromb Vasc Biol, 2012
Circulating A-FABP levels are associated with long-term prognosis in patients with coronary heart disease and may represent an important pathophysiological mediator of atherosclerosis.
TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex.
GeneRIF
Torchia et al., London, Canada. In Mol Cell, 2012
The p15(ink4b) promoter is a target for the ZNF217 oncogene, the CoREST complex, and DNMT3A.
Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages.
GeneRIF
Han et al., Tianjin, China. In Atherosclerosis, 2012
Report statins/dexamethasone synergistically induce FABP4 expression in macrophages.
The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element.
GeneRIF
Chen et al., Riverside, United States. In Development, 2012
APETALA2 recognizes and acts through an AT-rich sequence element to promote sepal and petal identities and restrict expression of AGAMOUS in whorls 1 and 2.
More papers using p15 antibodies
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
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Mandelkow Eckard et al., In The Journal of Cell Biology, 2002
... For fluorescent staining of the AP-2/clathrin-coated vesicles, cells were transfected overnight with 1 μg of the EGFP/β2-adaptin vector (β2-adaptin gene cloned into the SmaI–BamHI site of pEGFP-C1 (CLONTECH Laboratories, Inc.) using DOTAP ...
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
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Taub Dennis D. et al., In International Journal of Medical Sciences, 1999
... Membranes were probed with rabbit anti-PPARγ2 (Affinity BioReagents, CO) or rabbit-anti-aP2 (GeneTex, TX) antibodies.
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
Supplier
Parrilla Roberto et al., In BMC Molecular Biology, 1995
... against β-actin was from Sigma RBI (Madrid, Spain); mAbs against Sp-1 (sc-420x and sc-420) or AP2 (sc-25343x) were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Chromosome numbers and karyotypes of some Manihot species
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Rabinowicz Pablo D. et al., In Nature biotechnology, 1972
... WRINKLED1 encodes an AP2/EREB domain protein involved in the control of storage compound biosynthesis in Arabidopsis ...
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