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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

p140, KIR3DL2, Nup155
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: KIR, CAN, KIR2DL1, POLYMERASE, KIR2DL2
Papers on p140
[Juvenile dermatomyositis and new autoantibodies: Cases and review].
Belot et al., Marseille, France. In Arch Pediatr, Dec 2015
For these patients, the immunologic study found one patient positive for the MDA5 antibody (or CADM 140), one positive for the TIF1γ antibody (or p155/140), and two patients positive for the NXP2 antibody (or p140/MJ).
Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility.
Martinetti et al., Pavia, Italy. In Genes Immun, Oct 2015
Although no epistasis between HLA-A*11 and KIR2DS2/S4 emerged, HLA-A*11 also engages KIR3DL2, a framework gene encoding for a pathogen sensor of CpG-oligodeoxynucleotides (CpG-ODN), and KD blood mononuclear cells are actually prone to pathogen CpG-ODN activation in the acute phase.
A novel targeted immunotherapy for CTCL is on its way: Anti-KIR3DL2 mAb IPH4102 is potent and safe in non-clinical studies.
Marie-Cardine et al., Marseille, France. In Oncoimmunology, Sep 2015
An antibody-based CTCL-specific immunotherapy targeting the KIR3DL2 receptor expressed by the tumor cells in CTCL is currently under development and has shown encouraging results in pre-clinical studies.
DNA methylation as a promising landscape: A simple blood test for breast cancer prediction.
Tavakkoly Bazzaz et al., Tehrān, Iran. In Tumour Biol, Jul 2015
WBC's DNA was the focus of several case-control studies at both genome wide and candidate gene levels to reveal epigenetic changes accounting for predisposition to breast cancer, leading to suggest that ATM, TITF1, SFRP1, NUP155, NEUROD1, ZNF217, DBC2, DOK7 and ESR1 genes and the LINE1, Alu and Sat2 DNA elements could be considered as the potential epimarkers.
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.
Bowness et al., Athens, Greece. In Ann Rheum Dis, Jul 2015
CONCLUSIONS: ERAP1 activity determines surface expression of HLA-B27 FHCs and potentially promotes Th17 responses in AS through binding of HLA-B27 FHCs to KIR3DL2.
IL-23 responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear.
Elewaut et al., Gent, Belgium. In Curr Rheumatol Rep, May 2015
Although initially linked to T helper 17 cells, it is now clear that additional unconventional T cell subpopulations respond towards IL-23, including RORγt(+) CD3(+)CD4(-)CD8(-) T cells, TCRγδ17 cells, KIR3DL2(+)CD4(+) T cells and iNKT17 cells.
HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats.
Renner et al., Zürich, Switzerland. In Plos One, 2014
HD5 blocked cell-surface interaction of B272 with immune regulatory receptors KIR3DL2, LILRB2 and Pirb.
Killer-cell immunoglobulin-like receptors (KIR) and HLA-class I heavy chains in ankylosing spondylitis.
Mathieu et al., Cagliari, Italy. In Drug Dev Res, 2014
KIR3DL1 and possibly KIR3DS1 interact with classical B27, whereas KIR3DL2 binds B27 heavy chain dimers.
Lessons learned from gene expression profiling of cutaneous T-cell lymphoma.
Geskin et al., Pittsburgh, United States. In Br J Dermatol, 2013
Despite discordant results, several dysregulated genes have been identified across multiple studies, including PLS3, KIR3DL2, TWIST1 and STAT4.
New autoantibodies and their clinical associations in juvenile myositis - a systematic review.
Martini et al., In Acta Reumatol Port, 2013
METHODS: A systematic literature search was carried out to identify all studies concerning these novel MSAs (p155/140, p140, CADM-140, SAE and 200/100) in patients with JIIMs.
CD158k/KIR3DL2 and NKp46 are frequently expressed in transformed mycosis fungoides.
Bensussan et al., In Exp Dermatol, 2012
most frequently expressed KIR receptor in transformed mycosis fungoides
p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation.
Defilippi et al., Torino, Italy. In Oncogene, 2012
Data show that p140Cap suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility.
The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.
Hurley et al., Rockville, United States. In Immunogenetics, 2011
The frequencies of alleles of killer cell immunoglobulin-like receptor genes, KIR3DL3 and KIR3DL2, and the carrier frequency of KIR2DL4 alleles have been determined from a population of African Americans by DNA sequencing of the coding regions.
Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in preeclampsia.
Zhang et al., Beijing, China. In J Perinat Med, 2011
results suggest that carriers of A allele in exon 3 of killer cell immunoglobulin-like receptor 3DL2(KIR3DL2) have a decreased susceptibility to preeclampsia
Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.
Molkentin et al., Cincinnati, United States. In J Cell Biol, 2011
The Nup155-mediated localization was required for HDAC4's effect on gene expression.
Integrin signalling adaptors: not only figurants in the cancer story.
Defilippi et al., Torino, Italy. In Nat Rev Cancer, 2010
We specifically underline the contribution of p130 Crk-associated substrate (p130CAS; also known as BCAR1), neural precursor cell expressed, developmentally down-regulated 9 (NEDD9; also known as HEF1), CRK and the integrin-linked kinase (ILK)-pinch-parvin (IPP) complex to cancer, along with the more recently identified p140 Cas-associated protein (p140CAP; also known as SRCIN1).
Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.
Wang et al., Cleveland, United States. In Cell, 2009
These human and mouse studies indicate that loss of NUP155 function causes atrial fibrillation by altering mRNA and protein transport and link the nuclear pore complex to cardiovascular disease.
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.
Ibáñez et al., Stockholm, Sweden. In Cell, 2003
Association of NCAM with GFRalpha1, a GPI-anchored receptor for GDNF, downregulates NCAM-mediated cell adhesion and promotes high-affinity binding of GDNF to p140(NCAM), resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking RET, a known GDNF signaling receptor.
Small molecule nerve growth factor analogs image receptors in vivo.
Saragovi et al., United States. In Nat Biotechnol, 1996
The in vivo targeting efficacy of small molecule analogs of nerve growth factor (NGF) that bind the NGF receptor p140 TrkA was evaluated and compared with that of a high-affinity anti-TrkA monoclonal antibody (Mab 5C3).
Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.
Macara et al., Burlington, United States. In Nature, 1996
These results demonstrate a G-protein-coupled mechanism for Ras activation, mediated by p140 Ras-GRF.
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