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Golgi integral membrane protein 4

p138, GPP130
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Barr, CIs, Phosphogluconate Dehydrogenase, IgA, CAN
Papers on p138
Induced oligomerization targets Golgi proteins for degradation in lysosomes.
Linstedt et al., Pittsburgh, United States. In Mol Biol Cell, Jan 2016
Manganese protects cells against forms of Shiga toxin by down-regulating the cycling Golgi protein GPP130.
A Conserved Structural Motif Mediates Retrograde Trafficking of Shiga Toxin Types 1 and 2.
Mukhopadhyay et al., Austin, United States. In Traffic, Dec 2015
We previously demonstrated that residues in the corresponding β4-β5 loop of STx1B are required for interaction with GPP130, the STx1B-specific endosomal receptor, and for endosome-to-Golgi transport.
Manganese homeostasis in the nervous system.
Aschner et al., New York City, United States. In J Neurochem, Aug 2015
A manganese-specific sensor, GPP130, has been identified, which affords means for monitoring intracellular levels of this metal.
Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin.
Linstedt et al., Pittsburgh, United States. In Mol Biol Cell, 2014
Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the toxin uses as a trafficking receptor.
Shiga toxin-binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms.
Linstedt et al., Pittsburgh, United States. In Mol Biol Cell, 2013
Trafficking depends on the toxin B subunits, which for STx and STx1 are identical and bind GPP130, a manganese (Mn)-sensitive intracellular trafficking receptor.
Golgi phosphoprotein 4 (GPP130) is a sensitive and selective cellular target of manganese exposure.
Smith et al., Santa Cruz, United States. In Synapse, 2013
Here, we investigated the specificity, sensitivity, and time course of the Golgi Phosphoprotein 4 (GPP130) response to Mn exposure in AF5 GABAergic neuronal cells, and we determined the extent to which GPP130 degradation occurs in brain cells in vivo in rats subchronically exposed to Mn.
Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis.
Linstedt et al., Pittsburgh, United States. In Science, 2012
Mn(2+) targeted the cycling Golgi protein GPP130, which STx bound in control cells during sorting into Golgi-directed endosomal tubules that bypass lysosomes.
Interaction of Golgin-84 with the COG complex mediates the intra-Golgi retrograde transport.
Oda et al., Niigata, Japan. In Traffic, 2010
The depletion of golgin-84 caused fragmentation of the Golgi with the mislocalization of Golgi resident proteins, resulting in the accumulation of vesicles carrying intra-Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and cis-Golgi membrane protein GPP130.
Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130.
Linstedt et al., Pittsburgh, United States. In Mol Biol Cell, 2010
the stem domain of GPP130 is a novel Mn sensor in the Golgi lumen of mammalian cells
IgA antibodies against the Epstein-Barr nuclear antigen1 as a valuable biomarker for the diagnosis of nasopharyngeal carcinoma in Tunisian patients.
Hammami et al., Menzel Bourguiba, Tunisia. In J Med Virol, 2009
It was observed that the IgA Epstein-Barr nuclear antigen 1 (EBNA1), IgA early antigen (EA)-p138 and IgG EA-p138 antibodies represent the most specific anti-EBV responses in either young or older patients with nasopharyngeal carcinoma which yield higher positive rates compared to the three control groups.
SV40 large T antigen-specific human T cell memory responses.
Tabi et al., Cardiff, United Kingdom. In J Med Virol, 2008
Within SV40 Tag we identified three 15 amino acid-long immunogenic sequences and one 9 amino acid-long T cell epitope (p138) (138FPSELLSFL146), the latter including a HLA-B7-restriction motif.
Evaluation of commercial EBV RecombLine assay for diagnosis of nasopharyngeal carcinoma.
Middeldorp et al., Yogyakarta, Indonesia. In J Clin Virol, 2008
Few (<20%) healthy donors and patient controls showed IgG reactivity to EA proteins p47/54 and p138, yielding combined sensitivity/specificity and PPV/NPV values of 92.6%/98.3%
Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours.
Lerman et al., Frederick, United States. In J Pathol, 2008
We classify PL6 as a Golgi-resident protein based on its perinuclear co-localization with GPP130 in all cells and tissues analysed.
Native early antigen of Epstein-Barr virus, a promising antigen for diagnosis of nasopharyngeal carcinoma.
Middeldorp et al., Yogyakarta, Indonesia. In J Med Virol, 2007
Surprisingly, we found that a "low salt" native EA-protein extract reproducibly prepared from purified nuclei of EA-induced HH514 cells, and containing characteristic EA(D)-polypeptides, such as p47-54 (BMRF1), p138 (BALF2), p55-DNAse (BGLF5), and p65-TK (BXLF1), but without viral capsid (VCA) or nuclear antigen (EBNA) reactivity, gave highest sensitivity (90.4%) and specificity (95.5%) values for NPC diagnosis in both IgG and IgA ELISA.
Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130.
Storrie et al., Little Rock, United States. In Traffic, 2007
Multiple pH-regulated steps affect the trafficking of GPP130.
A cycling cis-Golgi protein mediates endosome-to-Golgi traffic.
Linstedt et al., Pittsburgh, United States. In Mol Biol Cell, 2004
GPP130 mediates exit from endosomes and thereby underlies Shiga toxin invasion and retrieval-based targeting of other cycling Golgi proteines
Expression of Golgi membrane protein p138 is cell cycle-independent and dissociated from centrosome duplication.
Yagura et al., Japan. In Cell Struct Funct, 2002
both the translation and transcription are regulated independent of the cell cycle and dissociated from the duplication of the centrosome
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